Atlas of Genetics and Cytogenetics in Oncology and Haematology

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IKBKG (inhibitor of nuclear factor kappa B kinase regulatory subunit gamma)

Identity

Alias_namesIP2
IP1
incontinentia pigmenti
inhibitor of kappa light polypeptide gene enhancer in B-cells, kinase gamma
inhibitor of nuclear factor kappa B kinase subunit gamma
Alias_symbol (synonym)IKK-gamma
NEMO
Fip3p
FIP-3
FIP3
ZC2HC9
Other aliasAMCBX1
EDAID1
IKKAP1
IKKG
IMD33
IP
IPD2
HGNC (Hugo) IKBKG
LocusID (NCBI) 8517
Atlas_Id 40938
Location Xq28  [Link to chromosome band Xq28]
Location_base_pair Starts at 154547847 and ends at 154565046 bp from pter ( according to hg38-Dec_2013)
Fusion genes
(updated 2017)		Data from Atlas, Mitelman, Cosmic Fusion, Fusion Cancer, TCGA fusion databases with official HUGO symbols (see references in chromosomal bands)
G6PD (Xq28) / IKBKG (Xq28)IKBKG (Xq28) / DAZAP1 (19p13.3)IKBKG (Xq28) / GAB3 (Xq28)
IKBKG Xq28 / GAB3 Xq28

Note

Non-annotated gene. Preliminary data : if you are an author
who wish to write a full paper/card on this gene, go to  How to contribute

DNA/RNA

 

External links

Nomenclature
HGNC (Hugo)IKBKG   5961
LRG (Locus Reference Genomic)LRG_70
Cards
Entrez_Gene (NCBI)IKBKG  8517  inhibitor of nuclear factor kappa B kinase regulatory subunit gamma
AliasesAMCBX1; EDAID1; FIP-3; FIP3; 
Fip3p; IKK-gamma; IKKAP1; IKKG; IMD33; IP; IP1; IP2; IPD2; NEMO; ZC2HC9
GeneCards (Weizmann)IKBKG
Ensembl hg19 (Hinxton)ENSG00000269335 [Gene_View]
Ensembl hg38 (Hinxton)ENSG00000269335 [Gene_View]  ENSG00000269335 [Sequence]  chrX:154547847-154565046 [Contig_View]  IKBKG [Vega]
ICGC DataPortalENSG00000269335
TCGA cBioPortalIKBKG
AceView (NCBI)IKBKG
Genatlas (Paris)IKBKG
WikiGenes8517
SOURCE (Princeton)IKBKG
Genetics Home Reference (NIH)IKBKG
Genomic and cartography
GoldenPath hg38 (UCSC)IKBKG  -     chrX:154547847-154565046 +  Xq28   [Description]    (hg38-Dec_2013)
GoldenPath hg19 (UCSC)IKBKG  -     Xq28   [Description]    (hg19-Feb_2009)
GoldenPathIKBKG - Xq28 [CytoView hg19]  IKBKG - Xq28 [CytoView hg38]
ImmunoBaseENSG00000269335
Mapping of homologs : NCBIIKBKG [Mapview hg19]  IKBKG [Mapview hg38]
OMIM300248   300291   300301   300584   300636   300640   308300   
Gene and transcription
Genbank (Entrez)AF062089 AF074382 AF091453 AF261086 AK000593
RefSeq transcript (Entrez)NM_001099856 NM_001099857 NM_001145255 NM_001321396 NM_001321397 NM_003639
RefSeq genomic (Entrez)
Consensus coding sequences : CCDS (NCBI)IKBKG
Cluster EST : UnigeneHs.43505 [ NCBI ]
CGAP (NCI)Hs.43505
Alternative Splicing GalleryENSG00000269335
Gene ExpressionIKBKG [ NCBI-GEO ]   IKBKG [ EBI - ARRAY_EXPRESS ]   IKBKG [ SEEK ]   IKBKG [ MEM ]
Gene Expression Viewer (FireBrowse)IKBKG [ Firebrowse - Broad ]
SOURCE (Princeton)Expression in : [Datasets]   [Normal Tissue Atlas]  [carcinoma Classsification]  [NCI60]
GenevestigatorExpression in : [tissues]  [cell-lines]  [cancer]  [perturbations]  
BioGPS (Tissue expression)8517
GTEX Portal (Tissue expression)IKBKG
Human Protein AtlasENSG00000269335-IKBKG [pathology]   [cell]   [tissue]
Protein : pattern, domain, 3D structure
UniProt/SwissProtQ9Y6K9   [function]  [subcellular_location]  [family_and_domains]  [pathology_and_biotech]  [ptm_processing]  [expression]  [interaction]
NextProtQ9Y6K9  [Sequence]  [Exons]  [Medical]  [Publications]
With graphics : InterProQ9Y6K9
Splice isoforms : SwissVarQ9Y6K9
PhosPhoSitePlusQ9Y6K9
Domaine pattern : Prosite (Expaxy)ZF_CCHC_NOA (PS51801)   
Domains : Interpro (EBI)CC2-LZ_dom    NEMO_N    NEMO_ZF   
Domain families : Pfam (Sanger)CC2-LZ (PF16516)    NEMO (PF11577)   
Domain families : Pfam (NCBI)pfam16516    pfam11577   
Conserved Domain (NCBI)IKBKG
DMDM Disease mutations8517
Blocks (Seattle)IKBKG
PDB (RSDB)2JVX    2JVY    3BRT    3BRV    3CL3    3FX0    4BWN    5AAY    5LDE   
PDB Europe2JVX    2JVY    3BRT    3BRV    3CL3    3FX0    4BWN    5AAY    5LDE   
PDB (PDBSum)2JVX    2JVY    3BRT    3BRV    3CL3    3FX0    4BWN    5AAY    5LDE   
PDB (IMB)2JVX    2JVY    3BRT    3BRV    3CL3    3FX0    4BWN    5AAY    5LDE   
Structural Biology KnowledgeBase2JVX    2JVY    3BRT    3BRV    3CL3    3FX0    4BWN    5AAY    5LDE   
SCOP (Structural Classification of Proteins)2JVX    2JVY    3BRT    3BRV    3CL3    3FX0    4BWN    5AAY    5LDE   
CATH (Classification of proteins structures)2JVX    2JVY    3BRT    3BRV    3CL3    3FX0    4BWN    5AAY    5LDE   
SuperfamilyQ9Y6K9
Human Protein Atlas [tissue]ENSG00000269335-IKBKG [tissue]
Peptide AtlasQ9Y6K9
HPRD02217
IPIIPI00002411   IPI00641117   IPI00641409   IPI00645990   IPI00644803   IPI00645282   IPI00852757   IPI00852832   IPI00852631   IPI00852720   IPI00927428   IPI01014787   
Protein Interaction databases
DIP (DOE-UCLA)Q9Y6K9
IntAct (EBI)Q9Y6K9
FunCoupENSG00000269335
BioGRIDIKBKG
STRING (EMBL)IKBKG
ZODIACIKBKG
Ontologies - Pathways
QuickGOQ9Y6K9
Ontology : AmiGOubiquitin ligase complex  activation of MAPK activity  spindle pole  stimulatory C-type lectin receptor signaling pathway  antigen processing and presentation of exogenous peptide antigen via MHC class I, TAP-dependent  MyD88-independent toll-like receptor signaling pathway  protein binding  intracellular  nucleus  nucleus  nucleoplasm  cytoplasm  cytoplasm  cytosol  cytosol  apoptotic process  inflammatory response  immune response  cellular response to DNA damage stimulus  cellular response to DNA damage stimulus  I-kappaB kinase/NF-kappaB signaling  JNK cascade  IkappaB kinase complex  IkappaB kinase complex  IkappaB kinase complex  response to virus  regulation of tumor necrosis factor-mediated signaling pathway  viral process  positive regulation of macroautophagy  protein deubiquitination  protein domain specific binding  ubiquitin protein ligase binding  TRIF-dependent toll-like receptor signaling pathway  Fc-epsilon receptor signaling pathway  identical protein binding  protein homodimerization activity  peroxisome proliferator activated receptor binding  positive regulation of I-kappaB kinase/NF-kappaB signaling  positive regulation of I-kappaB kinase/NF-kappaB signaling  positive regulation of I-kappaB kinase/NF-kappaB signaling  anoikis  innate immune response  positive regulation of transcription by RNA polymerase II  metal ion binding  protein heterodimerization activity  T cell receptor signaling pathway  T cell receptor signaling pathway  positive regulation of NF-kappaB transcription factor activity  positive regulation of NF-kappaB transcription factor activity  stress-activated MAPK cascade  establishment of vesicle localization  nucleotide-binding oligomerization domain containing signaling pathway  interleukin-1-mediated signaling pathway  K63-linked polyubiquitin modification-dependent protein binding  mitotic spindle  negative regulation of neuron death  linear polyubiquitin binding  
Ontology : EGO-EBIubiquitin ligase complex  activation of MAPK activity  spindle pole  stimulatory C-type lectin receptor signaling pathway  antigen processing and presentation of exogenous peptide antigen via MHC class I, TAP-dependent  MyD88-independent toll-like receptor signaling pathway  protein binding  intracellular  nucleus  nucleus  nucleoplasm  cytoplasm  cytoplasm  cytosol  cytosol  apoptotic process  inflammatory response  immune response  cellular response to DNA damage stimulus  cellular response to DNA damage stimulus  I-kappaB kinase/NF-kappaB signaling  JNK cascade  IkappaB kinase complex  IkappaB kinase complex  IkappaB kinase complex  response to virus  regulation of tumor necrosis factor-mediated signaling pathway  viral process  positive regulation of macroautophagy  protein deubiquitination  protein domain specific binding  ubiquitin protein ligase binding  TRIF-dependent toll-like receptor signaling pathway  Fc-epsilon receptor signaling pathway  identical protein binding  protein homodimerization activity  peroxisome proliferator activated receptor binding  positive regulation of I-kappaB kinase/NF-kappaB signaling  positive regulation of I-kappaB kinase/NF-kappaB signaling  positive regulation of I-kappaB kinase/NF-kappaB signaling  anoikis  innate immune response  positive regulation of transcription by RNA polymerase II  metal ion binding  protein heterodimerization activity  T cell receptor signaling pathway  T cell receptor signaling pathway  positive regulation of NF-kappaB transcription factor activity  positive regulation of NF-kappaB transcription factor activity  stress-activated MAPK cascade  establishment of vesicle localization  nucleotide-binding oligomerization domain containing signaling pathway  interleukin-1-mediated signaling pathway  K63-linked polyubiquitin modification-dependent protein binding  mitotic spindle  negative regulation of neuron death  linear polyubiquitin binding  
Pathways : KEGGMAPK signaling pathway    Ras signaling pathway    Chemokine signaling pathway    NF-kappa B signaling pathway    PI3K-Akt signaling pathway    Apoptosis    Osteoclast differentiation    Toll-like receptor signaling pathway    NOD-like receptor signaling pathway    RIG-I-like receptor signaling pathway    Cytosolic DNA-sensing pathway    T cell receptor signaling pathway    B cell receptor signaling pathway    TNF signaling pathway    Adipocytokine signaling pathway    Epithelial cell signaling in Helicobacter pylori infection    Shigellosis    Chagas disease (American trypanosomiasis)    Toxoplasmosis    Hepatitis C    Hepatitis B    HTLV-I infection    Herpes simplex infection    Epstein-Barr virus infection    Pathways in cancer    Viral carcinogenesis    Pancreatic cancer    Prostate cancer    Chronic myeloid leukemia    Acute myeloid leukemia    Small cell lung cancer    Primary immunodeficiency   
NDEx NetworkIKBKG
Atlas of Cancer Signalling NetworkIKBKG
Wikipedia pathwaysIKBKG
Orthology - Evolution
OrthoDB8517
GeneTree (enSembl)ENSG00000269335
Phylogenetic Trees/Animal Genes : TreeFamIKBKG
HOGENOMQ9Y6K9
Homologs : HomoloGeneIKBKG
Homology/Alignments : Family Browser (UCSC)IKBKG
Gene fusions - Rearrangements
Fusion PortalIKBKG Xq28 GAB3 Xq28 HNSC
Fusion : QuiverIKBKG
Polymorphisms : SNP and Copy number variants
NCBI Variation ViewerIKBKG [hg38]
dbSNP Single Nucleotide Polymorphism (NCBI)IKBKG
dbVarIKBKG
ClinVarIKBKG
1000_GenomesIKBKG 
Exome Variant ServerIKBKG
ExAC (Exome Aggregation Consortium)ENSG00000269335
GNOMAD BrowserENSG00000269335
Varsome BrowserIKBKG
Genetic variants : HAPMAP8517
Genomic Variants (DGV)IKBKG [DGVbeta]
DECIPHERIKBKG [patients]   [syndromes]   [variants]   [genes]  
CONAN: Copy Number AnalysisIKBKG 
Mutations
ICGC Data PortalIKBKG 
TCGA Data PortalIKBKG 
Broad Tumor PortalIKBKG
OASIS PortalIKBKG [ Somatic mutations - Copy number]
Somatic Mutations in Cancer : COSMICIKBKG  [overview]  [genome browser]  [tissue]  [distribution]  
Somatic Mutations in Cancer : COSMIC3DIKBKG
Mutations and Diseases : HGMDIKBKG
LOVD (Leiden Open Variation Database)Whole genome datasets
LOVD (Leiden Open Variation Database)LOVD - Leiden Open Variation Database
LOVD (Leiden Open Variation Database)LOVD 3.0 shared installation
LOVD (Leiden Open Variation Database)**PUBLIC** CCHMC Molecular Genetics Laboratory Mutation Database
BioMutasearch IKBKG
DgiDB (Drug Gene Interaction Database)IKBKG
DoCM (Curated mutations)IKBKG (select the gene name)
CIViC (Clinical Interpretations of Variants in Cancer)IKBKG (select a term)
intoGenIKBKG
Cancer3DIKBKG(select the gene name)
Impact of mutations[PolyPhen2] [Provean] [Buck Institute : MutDB] [Mutation Assessor] [Mutanalyser]
Diseases
OMIM300248    300291    300301    300584    300636    300640    308300   
Orphanet360    21682    10922    13830   
DisGeNETIKBKG
MedgenIKBKG
Genetic Testing Registry IKBKG
NextProtQ9Y6K9 [Medical]
TSGene8517
GENETestsIKBKG
Target ValidationIKBKG
Huge Navigator IKBKG [HugePedia]
snp3D : Map Gene to Disease8517
BioCentury BCIQIKBKG
ClinGenIKBKG (curated)
Clinical trials, drugs, therapy
Chemical/Protein Interactions : CTD8517
Chemical/Pharm GKB GenePA29777
Clinical trialIKBKG
Miscellaneous
canSAR (ICR)IKBKG (select the gene name)
DataMed IndexIKBKG
Probes
Litterature
PubMed434 Pubmed reference(s) in Entrez
GeneRIFsGene References Into Functions (Entrez)
CoreMineIKBKG
EVEXIKBKG
GoPubMedIKBKG
iHOPIKBKG
Genes in titleautomatic search in PubMed
REVIEW articlesautomatic search in PubMed
Last year publicationsautomatic search in PubMed

Search in all EBI   NCBI

© Atlas of Genetics and Cytogenetics in Oncology and Haematology
indexed on : Wed Nov 13 17:48:09 CET 2019
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