IL10RA (interleukin 10 receptor subunit alpha)

2007-02-01  

Identity

HGNC
IL10RA
LOCATION
11q23.3
LOCUSID
3587
ALIAS
CD210,CD210a,CDW210A,HIL-10R,IL-10R1,IL10R
FUSION GENES
Show Gene Fusions

Other Information

Locus ID:

NCBI: 3587
MIM: 146933
HGNC: 5964
Ensembl: ENSG00000110324

Variants:

dbSNP: 3587
ClinVar: 3587
TCGA: ENSG00000110324
COSMIC: IL10RA

RNA/Proteins

Gene IDTranscript IDUniprot
ENSG00000110324ENST00000227752Q13651
ENSG00000110324ENST00000526544E9PKU2
ENSG00000110324ENST00000534574E9PPU4

Expression (GTEx)

0
50
100
150
Adipose - Subcutaneous
Adipose - Visceral
Adrenal Gland
Artery - Aorta
Artery - Tibial
Bladder
Brain - Amygdala
Brain - Anterior cingulate cortex
Brain - Caudate
Brain - Cerebellar Hemisphere
Brain - Cerebellum
Brain - Cortex
Brain - Frontal Cortex
Brain - Hippocampus
Brain - Hypothalamus
Brain - Nucleus accumbens
Brain - Putamen
Brain - Spinal cord
Brain - Substantia nigra
Breast - Mammary Tissue
Cells - Cultured fibroblasts
Cells - EBV - transformed lymphocytes
Cervix - Ectocervix
Cervix - Endocervix
Colon - Sigmoid
Colon - Transverse
Esophagus - Gastroesophageal Junction
Esophagus - Mucosa
Esophagus - Muscularis
Fallopian Tube
Heart - Atrial Appendage
Heart - Left Ventricle
Kidney - Cortex
Kidney - Medulla
Liver
Lung
Minor Salivary Gland
Muscle - Skeletal
Nerve - Tibial
Ovary
Pancreas
Pituitary
Prostate
Skin - Not Sun Exposed
Skin - Sun Exposed
Small Intestine - Terminal Ileum
Spleen
Stomach
Testis
Thyroid
Uterus
Vagina
Whole Blood

Pathways

PathwaySourceExternal ID
Cytokine-cytokine receptor interactionKEGGko04060
Jak-STAT signaling pathwayKEGGko04630
Cytokine-cytokine receptor interactionKEGGhsa04060
Jak-STAT signaling pathwayKEGGhsa04630
ToxoplasmosisKEGGko05145
ToxoplasmosisKEGGhsa05145
TuberculosisKEGGko05152
TuberculosisKEGGhsa05152
Epstein-Barr virus infectionKEGGhsa05169
Epstein-Barr virus infectionKEGGko05169
Immune SystemREACTOMER-HSA-168256
Cytokine Signaling in Immune systemREACTOMER-HSA-1280215
Signaling by InterleukinsREACTOMER-HSA-449147
Interleukin-10 signalingREACTOMER-HSA-6783783

References

Pubmed IDYearTitleCitations
198901112009Inflammatory bowel disease and mutations affecting the interleukin-10 receptor.412
177034122007Genetic susceptibility to respiratory syncytial virus bronchiolitis is predominantly associated with innate immune genes.100
225490912012Loss of interleukin-10 signaling and infantile inflammatory bowel disease: implications for diagnosis and therapy.96
199131212009Gene-centric association signals for lipids and apolipoproteins identified via the HumanCVD BeadChip.85
225500142013IL-10R polymorphisms are associated with very-early-onset ulcerative colitis.76
120939202002Crystal structure of human cytomegalovirus IL-10 bound to soluble human IL-10R1.48
231663282013Cytokine response is determined by duration of receptor and signal transducers and activators of transcription 3 (STAT3) activation.42
190124932009Common variants in immune and DNA repair genes and risk for human papillomavirus persistence and progression to cervical cancer.41
288939582017Microbial-Derived Butyrate Promotes Epithelial Barrier Function through IL-10 Receptor-Dependent Repression of Claudin-2.40
169719562006Gene polymorphisms in Toll-like receptors, interleukin-10, and interleukin-10 receptor alpha and lymphoma risk.37

Citation

Dessen P

IL10RA (interleukin 10 receptor subunit alpha)

Atlas Genet Cytogenet Oncol Haematol. 2007-02-01

Online version: http://atlasgeneticsoncology.org/gene/46038/il10ra