IL10RB (interleukin 10 receptor subunit beta)

2014-02-01  

Identity

HGNC
LOCATION
21q22.11
LOCUSID
ALIAS
CDW210B,CRF2-4,CRFB4,D21S58,D21S66,IL-10R2
FUSION GENES

Other Information

Locus ID:

NCBI: 3588
MIM: 123889
HGNC: 5965
Ensembl: ENSG00000243646

Variants:

dbSNP: 3588
ClinVar: 3588
TCGA: ENSG00000243646
COSMIC: IL10RB

RNA/Proteins

Gene IDTranscript IDUniprot
ENSG00000243646ENST00000290200Q08334
ENSG00000243646ENST00000422891F8WDX2
ENSG00000243646ENST00000451065H7C0Z5
ENSG00000243646ENST00000609556A0A1B0GU52
ENSG00000243646ENST00000637650A0A1B0GTI5

Expression (GTEx)

0
10
20
30
40
50
60

Pathways

PathwaySourceExternal ID
Cytokine-cytokine receptor interactionKEGGko04060
Jak-STAT signaling pathwayKEGGko04630
Cytokine-cytokine receptor interactionKEGGhsa04060
Jak-STAT signaling pathwayKEGGhsa04630
ToxoplasmosisKEGGko05145
ToxoplasmosisKEGGhsa05145
TuberculosisKEGGko05152
TuberculosisKEGGhsa05152
Epstein-Barr virus infectionKEGGhsa05169
Epstein-Barr virus infectionKEGGko05169
Immune SystemREACTOMER-HSA-168256
Cytokine Signaling in Immune systemREACTOMER-HSA-1280215
Signaling by InterleukinsREACTOMER-HSA-449147
Interleukin-19, 20, 22, 24REACTOMER-HSA-8854691
Interleukin-10 signalingREACTOMER-HSA-6783783

Protein levels (Protein atlas)

Not detected
Low
Medium
High

References

Pubmed IDYearTitleCitations
124832102003IFN-lambdas mediate antiviral protection through a distinct class II cytokine receptor complex.581
198901112009Inflammatory bowel disease and mutations affecting the interleukin-10 receptor.412
177034122007Genetic susceptibility to respiratory syncytial virus bronchiolitis is predominantly associated with innate immune genes.100
225490912012Loss of interleukin-10 signaling and infantile inflammatory bowel disease: implications for diagnosis and therapy.96
199131212009Gene-centric association signals for lipids and apolipoproteins identified via the HumanCVD BeadChip.85
225500142013IL-10R polymorphisms are associated with very-early-onset ulcerative colitis.76
151786812004The T-cell lymphokine interleukin-26 targets epithelial cells through the interleukin-20 receptor 1 and interleukin-10 receptor 2 chains.40
171520052007Associations between measles vaccine immunity and single-nucleotide polymorphisms in cytokine and cytokine receptor genes.34
208116262010Genetic variants in inflammation-related genes are associated with radiation-induced toxicity following treatment for non-small cell lung cancer.34
240893282013A Mendelian predisposition to B-cell lymphoma caused by IL-10R deficiency.32

Citation

Dessen P

IL10RB (interleukin 10 receptor subunit beta)

Atlas Genet Cytogenet Oncol Haematol. 2014-02-01

Online version: http://atlasgeneticsoncology.org/gene/53793/il10rb