IL11RA (interleukin 11 receptor subunit alpha)

2007-02-01  

Identity

HGNC
LOCATION
9p13.3
LOCUSID
ALIAS
CRSDA
FUSION GENES

Other Information

Locus ID:

NCBI: 3590
MIM: 600939
HGNC: 5967
Ensembl: ENSG00000137070

Variants:

dbSNP: 3590
ClinVar: 3590
TCGA: ENSG00000137070
COSMIC: IL11RA

RNA/Proteins

Gene IDTranscript IDUniprot
ENSG00000137070ENST00000318041Q14626
ENSG00000137070ENST00000318041Q5VZ79
ENSG00000137070ENST00000441545Q14626
ENSG00000137070ENST00000441545Q5VZ79
ENSG00000137070ENST00000466082H0YCS8
ENSG00000137070ENST00000553620G3V571
ENSG00000137070ENST00000555003Q14626
ENSG00000137070ENST00000555003Q5VZ79
ENSG00000137070ENST00000555247G3V2J5
ENSG00000137070ENST00000555981G3V2G0
ENSG00000137070ENST00000556531G3V3V2
ENSG00000137070ENST00000556792G3V2A5
ENSG00000137070ENST00000557298G3V428
ENSG00000137070ENST00000602473Q14626

Expression (GTEx)

0
10
20
30
40
50
60
70
80
90

Pathways

PathwaySourceExternal ID
Cytokine-cytokine receptor interactionKEGGko04060
Jak-STAT signaling pathwayKEGGko04630
Hematopoietic cell lineageKEGGko04640
Cytokine-cytokine receptor interactionKEGGhsa04060
Jak-STAT signaling pathwayKEGGhsa04630
Hematopoietic cell lineageKEGGhsa04640
Immune SystemREACTOMER-HSA-168256
Cytokine Signaling in Immune systemREACTOMER-HSA-1280215
Signaling by InterleukinsREACTOMER-HSA-449147
Interleukin-6 family signalingREACTOMER-HSA-6783589
IL-6-type cytokine receptor ligand interactionsREACTOMER-HSA-6788467

Protein levels (Protein atlas)

Not detected
Low
Medium
High

References

Pubmed IDYearTitleCitations
378204522023Biophysical insight into protein-protein interactions in the Interleukin-11/Interleukin-11Rα/glycoprotein 130 signaling complex.0
378204522023Biophysical insight into protein-protein interactions in the Interleukin-11/Interleukin-11Rα/glycoprotein 130 signaling complex.0
353319372022The outcome of targeted NGS screening in patients with syndromic forms of sagittal and pansynostosis - IL11RA is an emerging core-gene for pansynostosis.2
363768852022IL-11 system participates in pulmonary artery remodeling and hypertension in pulmonary fibrosis.12
353319372022The outcome of targeted NGS screening in patients with syndromic forms of sagittal and pansynostosis - IL11RA is an emerging core-gene for pansynostosis.2
363768852022IL-11 system participates in pulmonary artery remodeling and hypertension in pulmonary fibrosis.12
335663792021Interleukin-11 (IL-11) receptor cleavage by the rhomboid protease RHBDL2 induces IL-11 trans-signaling.11
335908752021IL11 is elevated in systemic sclerosis and IL11-dependent ERK signalling underlies TGFβ-mediated activation of dermal fibroblasts.24
345303292021Interleukin-11 receptor expression on monocytes is dispensable for their recruitment and pathogen uptake during Leishmania major infection.1
335663792021Interleukin-11 (IL-11) receptor cleavage by the rhomboid protease RHBDL2 induces IL-11 trans-signaling.11
335908752021IL11 is elevated in systemic sclerosis and IL11-dependent ERK signalling underlies TGFβ-mediated activation of dermal fibroblasts.24
345303292021Interleukin-11 receptor expression on monocytes is dispensable for their recruitment and pathogen uptake during Leishmania major infection.1
322775092020Multiple craniosynostosis and facial dysmorphisms with homozygous IL11RA variant caused by maternal uniparental isodisomy of chromosome 9.4
323321002020The structure of the extracellular domains of human interleukin 11α receptor reveals mechanisms of cytokine engagement.20
322775092020Multiple craniosynostosis and facial dysmorphisms with homozygous IL11RA variant caused by maternal uniparental isodisomy of chromosome 9.4

Citation

Dessen P

IL11RA (interleukin 11 receptor subunit alpha)

Atlas Genet Cytogenet Oncol Haematol. 2007-02-01

Online version: http://atlasgeneticsoncology.org/gene/45838/il11ra