IL15RA (interleukin 15 receptor subunit alpha)

2007-02-01  

Identity

HGNC
IL15RA
LOCATION
10p15.1
LOCUSID
3601
ALIAS
CD215

Other Information

Locus ID:

NCBI: 3601
MIM: 601070
HGNC: 5978
Ensembl: ENSG00000134470

Variants:

dbSNP: 3601
ClinVar: 3601
TCGA: ENSG00000134470
COSMIC: IL15RA

RNA/Proteins

Gene IDTranscript IDUniprot
ENSG00000134470ENST00000379971Q13261
ENSG00000134470ENST00000379977Q13261
ENSG00000134470ENST00000397246E7ETI1
ENSG00000134470ENST00000397248A0A0A0MS77
ENSG00000134470ENST00000397250Q13261
ENSG00000134470ENST00000397251K9N1J3
ENSG00000134470ENST00000397255Q13261
ENSG00000134470ENST00000429135E9PQ64
ENSG00000134470ENST00000435171H0Y4R3
ENSG00000134470ENST00000447291H0Y6E8
ENSG00000134470ENST00000453922Q5JVA3
ENSG00000134470ENST00000525219Q13261
ENSG00000134470ENST00000528354Q13261
ENSG00000134470ENST00000530685Q13261
ENSG00000134470ENST00000532039H0YD11
ENSG00000134470ENST00000620345K9N163
ENSG00000134470ENST00000620865K9N2S2
ENSG00000134470ENST00000622442K9N2Q6

Expression (GTEx)

0
5
10
15
20
25
30
35
40
45
50
Adipose - Subcutaneous
Adipose - Visceral
Adrenal Gland
Artery - Aorta
Artery - Tibial
Bladder
Brain - Amygdala
Brain - Anterior cingulate cortex
Brain - Caudate
Brain - Cerebellar Hemisphere
Brain - Cerebellum
Brain - Cortex
Brain - Frontal Cortex
Brain - Hippocampus
Brain - Hypothalamus
Brain - Nucleus accumbens
Brain - Putamen
Brain - Spinal cord
Brain - Substantia nigra
Breast - Mammary Tissue
Cells - Cultured fibroblasts
Cells - EBV - transformed lymphocytes
Cervix - Ectocervix
Cervix - Endocervix
Colon - Sigmoid
Colon - Transverse
Esophagus - Gastroesophageal Junction
Esophagus - Mucosa
Esophagus - Muscularis
Fallopian Tube
Heart - Atrial Appendage
Heart - Left Ventricle
Kidney - Cortex
Kidney - Medulla
Liver
Lung
Minor Salivary Gland
Muscle - Skeletal
Nerve - Tibial
Ovary
Pancreas
Pituitary
Prostate
Skin - Not Sun Exposed
Skin - Sun Exposed
Small Intestine - Terminal Ileum
Spleen
Stomach
Testis
Thyroid
Uterus
Vagina
Whole Blood

Pathways

PathwaySourceExternal ID
Cytokine-cytokine receptor interactionKEGGko04060
Jak-STAT signaling pathwayKEGGko04630
Cytokine-cytokine receptor interactionKEGGhsa04060
Jak-STAT signaling pathwayKEGGhsa04630
Intestinal immune network for IgA productionKEGGko04672
Intestinal immune network for IgA productionKEGGhsa04672
HTLV-I infectionKEGGko05166
HTLV-I infectionKEGGhsa05166
Immune SystemREACTOMER-HSA-168256
Cytokine Signaling in Immune systemREACTOMER-HSA-1280215
Signaling by InterleukinsREACTOMER-HSA-449147

Protein levels (Protein atlas)

Not detected
Low
Medium
High
cerebral cortex
cerebellum
hippocampus
caudate
thyroid gland
parathyroid gland
adrenal gland
nasopharynx
bronchus
lung
oral mucosa
salivary gland
esophagus
stomach 1
stomach 2
duodenum
small intestine
colon
rectum
liver
gallbladder
pancreas
kidney
urinary bladder
testis
epididymis
seminal vesicle
prostate
vagina
ovary
fallopian tube
endometrium 1
endometrium 2
cervix, uterine
placenta
breast
heart muscle
smooth muscle
skeletal muscle
soft tissue 1
soft tissue 2
adipose tissue
skin 1
skin 2
appendix
spleen
lymph node
tonsil
bone marrow

References

Pubmed IDYearTitleCitations
167575672006Converting IL-15 to a superagonist by binding to soluble IL-15R{alpha}.158
177034122007Genetic susceptibility to respiratory syncytial virus bronchiolitis is predominantly associated with innate immune genes.100
162844002006Soluble interleukin-15 receptor alpha (IL-15R alpha)-sushi as a selective and potent agonist of IL-15 action through IL-15R beta/gamma. Hyperagonist IL-15 x IL-15R alpha fusion proteins.79
192400612009Coeliac disease-associated risk variants in TNFAIP3 and REL implicate altered NF-kappaB signalling.75
163854512006A scan of chromosome 10 identifies a novel locus showing strong association with late-onset Alzheimer disease.69
224961502012Circulating IL-15 exists as heterodimeric complex with soluble IL-15Rα in human and mouse serum.63
155315732004Association of interleukin-15 protein and interleukin-15 receptor genetic variation with resistance exercise training responses.52
152658972004Natural, proteolytic release of a soluble form of human IL-15 receptor alpha-chain that behaves as a specific, high affinity IL-15 antagonist.45
179481252007NK cell survival mediated through the regulatory synapse with human DCs requires IL-15Ralpha.40
152630762004IL-2 and IL-15 receptor alpha-subunits are coexpressed in a supramolecular receptor cluster in lipid rafts of T cells.37

Citation

Dessen P

IL15RA (interleukin 15 receptor subunit alpha)

Atlas Genet Cytogenet Oncol Haematol. 2007-02-01

Online version: http://atlasgeneticsoncology.org/gene/43964/il15ra