IL17RC (interleukin 17 receptor C)

2007-02-01  

Identity

HGNC
LOCATION
3p25.3
LOCUSID
ALIAS
CANDF9,IL17-RL,IL17RL
FUSION GENES

Other Information

Locus ID:

NCBI: 84818
MIM: 610925
HGNC: 18358
Ensembl: ENSG00000163702

Variants:

dbSNP: 84818
ClinVar: 84818
TCGA: ENSG00000163702
COSMIC: IL17RC

RNA/Proteins

Gene IDTranscript IDUniprot
ENSG00000163702ENST00000295981Q8NAC3
ENSG00000163702ENST00000383812Q8NAC3
ENSG00000163702ENST00000403601Q8NAC3
ENSG00000163702ENST00000412901B4DI24
ENSG00000163702ENST00000413608Q8NAC3
ENSG00000163702ENST00000416074Q8NAC3
ENSG00000163702ENST00000424206F8WD65
ENSG00000163702ENST00000434756F8WE27
ENSG00000163702ENST00000436503C9K0M1
ENSG00000163702ENST00000438091C9JSZ3
ENSG00000163702ENST00000440502F8WEG5
ENSG00000163702ENST00000451165F6X4Z5
ENSG00000163702ENST00000451231F8WB43
ENSG00000163702ENST00000451271F8WC09
ENSG00000163702ENST00000455057Q8NAC3
ENSG00000163702ENST00000476810G3V177
ENSG00000163702ENST00000498214A8K3Q5

Expression (GTEx)

0
50
100
150

Pathways

PathwaySourceExternal ID
Cytokine-cytokine receptor interactionKEGGko04060
Cytokine-cytokine receptor interactionKEGGhsa04060
Immune SystemREACTOMER-HSA-168256
Cytokine Signaling in Immune systemREACTOMER-HSA-1280215
Signaling by InterleukinsREACTOMER-HSA-449147
Interleukin-17 signalingREACTOMER-HSA-448424
IL-17 signaling pathwayKEGGko04657
IL-17 signaling pathwayKEGGhsa04657

Protein levels (Protein atlas)

Not detected
Low
Medium
High

References

Pubmed IDYearTitleCitations
167854952006Cutting edge: interleukin 17 signals through a heteromeric receptor complex.182
179116332007Identification of the IL-17 receptor related molecule IL-17RC as the receptor for IL-17F.106
186849712008The human IL-17F/IL-17A heterodimeric cytokine signals through the IL-17RA/IL-17RC receptor complex.77
201730242010IL-17 contributes to angiogenesis in rheumatoid arthritis.61
259183422015Inherited IL-17RC deficiency in patients with chronic mucocutaneous candidiasis.59
180970682008IL-17RA and IL-17RC receptors are essential for IL-17A-induced ELR+ CXC chemokine expression in synoviocytes and are overexpressed in rheumatoid blood.45
228989222012Th17-associated cytokines promote human airway smooth muscle cell proliferation.44
271553662016Neutrophils from F508del cystic fibrosis patients produce IL-17A and express IL-23 - dependent IL-17RC.11
166887462006Generation of interleukin-17 receptor-like protein (IL-17RL) in prostate by alternative splicing of RNA.9
229990502012A single-nucleotide polymorphism rs708567 in the IL-17RC gene is associated with a susceptibility to and the curve severity of adolescent idiopathic scoliosis in a Chinese Han population: a case-control study.8

Citation

Dessen P

IL17RC (interleukin 17 receptor C)

Atlas Genet Cytogenet Oncol Haematol. 2007-02-01

Online version: http://atlasgeneticsoncology.org/gene/46195/il17rc