Identity
HGNC
LOCATION
11q23.1
LOCUSID
ALIAS
IGIF,IL-18,IL-1g,IL1F4
FUSION GENES
Non-annotated gene. Preliminary data : if you are an author who wish to write a full paper/card on this gene, contribute in submission tool
Other Information
Locus ID:
NCBI: 3606
MIM: 600953
HGNC: 5986
Ensembl: ENSG00000150782
Variants:
dbSNP: 3606
ClinVar: 3606
TCGA: ENSG00000150782
COSMIC: IL18
RNA/Proteins
| Gene ID | Transcript ID | Uniprot |
|---|---|---|
| ENSG00000150782 | ENST00000280357 | Q14116 |
| ENSG00000150782 | ENST00000524595 | Q14116 |
| ENSG00000150782 | ENST00000524595 | A0A024R3E0 |
| ENSG00000150782 | ENST00000528832 | Q14116 |
Expression (GTEx)
Pathways
Protein levels (Protein atlas)
PharmGKB
| Entity ID | Name | Type | Evidence | Association | PK | PD | PMIDs |
|---|---|---|---|---|---|---|---|
| PA134850491 | Transplantation | Disease | ClinicalAnnotation | associated | PK | 25712187 | |
| PA165817016 | Kidney Transplantation | Disease | ClinicalAnnotation | associated | PK | 25487141 | |
| PA166114457 | lung transplantation | Disease | ClinicalAnnotation | associated | PK | 25487141 | |
| PA446863 | Hepatitis C, Chronic | Disease | ClinicalAnnotation | associated | PD | 19455410 | |
| PA451241 | ribavirin | Chemical | ClinicalAnnotation | associated | PD | 19455410 | |
| PA451578 | tacrolimus | Chemical | ClinicalAnnotation | associated | PK | 25487141, 25712187 | |
| PA451999 | interferons | Chemical | ClinicalAnnotation | associated | PD | 19455410 |
References
| Pubmed ID | Year | Title | Citations |
|---|---|---|---|
| 37480196 | 2024 | Association of salivary levels of DNA sensing inflammasomes AIM2, IFI16, and cytokine IL18 with periodontitis and diabetes. | 0 |
| 37848720 | 2024 | Angiogenesis related genes in Takayasu Arteritis (TAK): robust association with Tag SNPs of IL-18 and FGF-2 in a South Asian Cohort. | 0 |
| 37933422 | 2024 | Altered ventricular longitudinal strain in children with sickle cell disease: Role of TGF-β and IL-18. | 0 |
| 37934469 | 2024 | Activation of the Interleukin-18 Signaling Pathway via Direct Receptor Dimerization in the Absence of Interleukin-18. | 0 |
| 37964584 | 2024 | Serum concentrations of 25-OH vitamin D and the pro-inflammatory interleukins IL-17, IL-23, and IL-18 in patients with plaque psoriasis. | 0 |
| 38128426 | 2024 | Protective effects of IL18-105G > A and IL18-137C > Ggenetic variants on severity of COVID-19. | 0 |
| 38216380 | 2024 | Association of carotid atheroma plaque with IL-18 levels and with polymorphisms in the IL-18 receptor gene in a Mediterranean population. | 0 |
| 38295914 | 2024 | Interleukin-18 in chronic pain: Focus on pathogenic mechanisms and potential therapeutic targets. | 0 |
| 38325197 | 2024 | Expression of lymphocyte activation gene-3 on CD4(+)T cells is regulated by cytokine interleukin-18 in myasthenia gravis. | 0 |
| 38328001 | 2024 | Interleukin-18 Gene Polymorphisms and Rheumatoid Arthritis Susceptibility: An Umbrella Review of Meta-Analyses. | 0 |
| 38338685 | 2024 | Higher Renal Net Acid Excretion, but Not Higher Phosphate Excretion, during Childhood and Adolescence Associates with the Circulating Renal Tubular Injury Marker Interleukin-18 in Adulthood. | 0 |
| 38339924 | 2024 | Relationship between vitamin D receptor genotypes (FOK1rs2228570) and IL18 gene expression in sample of multiple sclerosis Iraqi patients. | 0 |
| 38402570 | 2024 | Prognostic significance of IL-18 in acute coronary syndrome patients. | 0 |
| 38407846 | 2024 | Genetically predicted circulating interleukin-18 levels are associated with risk of systemic lupus erythematosus and type 1 diabetes. | 0 |
| 38408992 | 2024 | Reduced interleukin-18 secretion by human monocytic cells in response to infections with hyper-virulent Streptococcus pyogenes. | 0 |
Citation
Dessen P
IL18 (interleukin 18)
Atlas Genet Cytogenet Oncol Haematol. 2003-08-01
Online version: http://atlasgeneticsoncology.org/gene/40947/il18
