IL18R1 (interleukin 18 receptor 1)

2003-11-01  

Identity

HGNC
LOCATION
2q12.1
LOCUSID
ALIAS
CD218a,CDw218a,IL-18R-alpha,IL-18Ralpha,IL-1Rrp,IL18RA,IL18Ralpha2,IL1RRP
FUSION GENES

Other Information

Locus ID:

NCBI: 8809
MIM: 604494
HGNC: 5988
Ensembl: ENSG00000115604

Variants:

dbSNP: 8809
ClinVar: 8809
TCGA: ENSG00000115604
COSMIC: IL18R1

RNA/Proteins

Gene IDTranscript IDUniprot
ENSG00000115604ENST00000233957Q13478
ENSG00000115604ENST00000334376Q86YL8
ENSG00000115604ENST00000409599Q13478
ENSG00000115604ENST00000410040Q13478

Expression (GTEx)

0
5
10
15
20
25
30
35
40
45
50

Pathways

PathwaySourceExternal ID
Cytokine-cytokine receptor interactionKEGGko04060
Cytokine-cytokine receptor interactionKEGGhsa04060
TNF signaling pathwayKEGGhsa04668
TNF signaling pathwayKEGGko04668
Inflammatory bowel disease (IBD)KEGGhsa05321
Inflammatory bowel disease (IBD)KEGGko05321
Immune SystemREACTOMER-HSA-168256
Cytokine Signaling in Immune systemREACTOMER-HSA-1280215
Signaling by InterleukinsREACTOMER-HSA-449147

Protein levels (Protein atlas)

Not detected
Low
Medium
High

References

Pubmed IDYearTitleCitations
208605032010A large-scale, consortium-based genomewide association study of asthma.610
147345512004Interleukin (IL)-1F6, IL-1F8, and IL-1F9 signal through IL-1Rrp2 and IL-1RAcP to activate the pathway leading to NF-kappaB and MAPKs.121
192490082009Diverse genome-wide association studies associate the IL12/IL23 pathway with Crohn Disease.109
177034122007Genetic susceptibility to respiratory syncytial virus bronchiolitis is predominantly associated with innate immune genes.100
257299232015IL-37 requires the receptors IL-18Rα and IL-1R8 (SIGIRR) to carry out its multifaceted anti-inflammatory program upon innate signal transduction.96
203796142010Personalized smoking cessation: interactions between nicotine dose, dependence and quit-success genotype score.62
160436442005Genetic analysis of the interleukin-18 system highlights the role of the interleukin-18 gene in cardiovascular disease.49
208338392010IL-1RL2 and its ligands contribute to the cytokine network in psoriasis.47
208161952010Analyses of shared genetic factors between asthma and obesity in children.43
199100302010Evaluation of candidate genes in a genome-wide association study of childhood asthma in Mexicans.41

Citation

Dessen P

IL18R1 (interleukin 18 receptor 1)

Atlas Genet Cytogenet Oncol Haematol. 2003-11-01

Online version: http://atlasgeneticsoncology.org/gene/40948/il18r1