IL1RAP (interleukin 1 receptor accessory protein)

2003-05-01  

Identity

HGNC
IL1RAP
LOCATION
3q28
LOCUSID
3556
ALIAS
C3orf13,IL-1RAcP,IL1R3
FUSION GENES
Show Gene Fusions

Other Information

Locus ID:

NCBI: 3556
MIM: 602626
HGNC: 5995
Ensembl: ENSG00000196083

Variants:

dbSNP: 3556
ClinVar: 3556
TCGA: ENSG00000196083
COSMIC: IL1RAP

RNA/Proteins

Gene IDTranscript IDUniprot
ENSG00000196083ENST00000072516Q9NPH3
ENSG00000196083ENST00000317757Q9NPH3
ENSG00000196083ENST00000342550Q9NPH3
ENSG00000196083ENST00000412080H7C3W4
ENSG00000196083ENST00000412504Q9NPH3
ENSG00000196083ENST00000413869Q9NPH3
ENSG00000196083ENST00000422485Q9NPH3
ENSG00000196083ENST00000422625C9JT28
ENSG00000196083ENST00000422940Q9NPH3
ENSG00000196083ENST00000434491C9J9W1
ENSG00000196083ENST00000439062Q9NPH3
ENSG00000196083ENST00000443369Q9NPH3
ENSG00000196083ENST00000447382Q9NPH3
ENSG00000196083ENST00000453359C9J1D9

Expression (GTEx)

0
5
10
15
Adipose - Subcutaneous
Adipose - Visceral
Adrenal Gland
Artery - Aorta
Artery - Tibial
Bladder
Brain - Amygdala
Brain - Anterior cingulate cortex
Brain - Caudate
Brain - Cerebellar Hemisphere
Brain - Cerebellum
Brain - Cortex
Brain - Frontal Cortex
Brain - Hippocampus
Brain - Hypothalamus
Brain - Nucleus accumbens
Brain - Putamen
Brain - Spinal cord
Brain - Substantia nigra
Breast - Mammary Tissue
Cells - Cultured fibroblasts
Cells - EBV - transformed lymphocytes
Cervix - Ectocervix
Cervix - Endocervix
Colon - Sigmoid
Colon - Transverse
Esophagus - Gastroesophageal Junction
Esophagus - Mucosa
Esophagus - Muscularis
Fallopian Tube
Heart - Atrial Appendage
Heart - Left Ventricle
Kidney - Cortex
Kidney - Medulla
Liver
Lung
Minor Salivary Gland
Muscle - Skeletal
Nerve - Tibial
Ovary
Pancreas
Pituitary
Prostate
Skin - Not Sun Exposed
Skin - Sun Exposed
Small Intestine - Terminal Ileum
Spleen
Stomach
Testis
Thyroid
Uterus
Vagina
Whole Blood

Pathways

PathwaySourceExternal ID
Cytokine-cytokine receptor interactionKEGGko04060
Cytokine-cytokine receptor interactionKEGGhsa04060
Inflammatory mediator regulation of TRP channelsKEGGhsa04750
Inflammatory mediator regulation of TRP channelsKEGGko04750
Immune SystemREACTOMER-HSA-168256
Cytokine Signaling in Immune systemREACTOMER-HSA-1280215
Signaling by InterleukinsREACTOMER-HSA-449147
Interleukin-1 signalingREACTOMER-HSA-446652
Th17 cell differentiationKEGGko04659
Th17 cell differentiationKEGGhsa04659

Protein levels (Protein atlas)

Not detected
Low
Medium
High
cerebral cortex
cerebellum
hippocampus
caudate
thyroid gland
parathyroid gland
adrenal gland
nasopharynx
bronchus
lung
oral mucosa
salivary gland
esophagus
stomach 1
stomach 2
duodenum
small intestine
colon
rectum
liver
gallbladder
pancreas
kidney
urinary bladder
testis
epididymis
seminal vesicle
prostate
vagina
ovary
fallopian tube
endometrium 1
endometrium 2
cervix, uterine
placenta
breast
heart muscle
smooth muscle
skeletal muscle
soft tissue 1
soft tissue 2
adipose tissue
skin 1
skin 2
appendix
spleen
lymph node
tonsil
bone marrow

References

Pubmed IDYearTitleCitations
147345512004Interleukin (IL)-1F6, IL-1F8, and IL-1F9 signal through IL-1Rrp2 and IL-1RAcP to activate the pathway leading to NF-kappaB and MAPKs.121
199131212009Gene-centric association signals for lipids and apolipoproteins identified via the HumanCVD BeadChip.85
192400612009Coeliac disease-associated risk variants in TNFAIP3 and REL implicate altered NF-kappaB signalling.75
203796142010Personalized smoking cessation: interactions between nicotine dose, dependence and quit-success genotype score.62
227235522012Overexpression of IL-1 receptor accessory protein in stem and progenitor cells and outcome correlation in AML and MDS.59
208054742010Isolation and killing of candidate chronic myeloid leukemia stem cells by antibody targeting of IL-1 receptor accessory protein.48
125309782003The soluble form of IL-1 receptor accessory protein enhances the ability of soluble type II IL-1 receptor to inhibit IL-1 action.45
239801702013Structural insights into the interaction of IL-33 with its receptors.45
194814782009A central nervous system-restricted isoform of the interleukin-1 receptor accessory protein modulates neuronal responses to interleukin-1.44
123936992002Host defense and inflammatory gene polymorphisms are associated with outcomes after HLA-identical sibling bone marrow transplantation.41

Citation

Dessen P

IL1RAP (interleukin 1 receptor accessory protein)

Atlas Genet Cytogenet Oncol Haematol. 2003-05-01

Online version: http://atlasgeneticsoncology.org/gene/40952/il1rap