IL1RL1 (interleukin 1 receptor like 1)

2007-02-01  

Identity

HGNC
IL1RL1
LOCATION
2q12.1
LOCUSID
9173
ALIAS
DER4,FIT-1,IL33R,ST2,ST2L,ST2V,T1

Other Information

Locus ID:

NCBI: 9173
MIM: 601203
HGNC: 5998
Ensembl: ENSG00000115602

Variants:

dbSNP: 9173
ClinVar: 9173
TCGA: ENSG00000115602
COSMIC: IL1RL1

RNA/Proteins

Gene IDTranscript IDUniprot
ENSG00000115602ENST00000233954Q01638
ENSG00000115602ENST00000311734Q01638
ENSG00000115602ENST00000404917Q01638
ENSG00000115602ENST00000409584E9PC41
ENSG00000115602ENST00000427077Q01638
ENSG00000115602ENST00000447231C9JSY6

Expression (GTEx)

0
50
100
150
Adipose - Subcutaneous
Adipose - Visceral
Adrenal Gland
Artery - Aorta
Artery - Tibial
Bladder
Brain - Amygdala
Brain - Anterior cingulate cortex
Brain - Caudate
Brain - Cerebellar Hemisphere
Brain - Cerebellum
Brain - Cortex
Brain - Frontal Cortex
Brain - Hippocampus
Brain - Hypothalamus
Brain - Nucleus accumbens
Brain - Putamen
Brain - Spinal cord
Brain - Substantia nigra
Breast - Mammary Tissue
Cells - Cultured fibroblasts
Cells - EBV - transformed lymphocytes
Cervix - Ectocervix
Cervix - Endocervix
Colon - Sigmoid
Colon - Transverse
Esophagus - Gastroesophageal Junction
Esophagus - Mucosa
Esophagus - Muscularis
Fallopian Tube
Heart - Atrial Appendage
Heart - Left Ventricle
Kidney - Cortex
Kidney - Medulla
Liver
Lung
Minor Salivary Gland
Muscle - Skeletal
Nerve - Tibial
Ovary
Pancreas
Pituitary
Prostate
Skin - Not Sun Exposed
Skin - Sun Exposed
Small Intestine - Terminal Ileum
Spleen
Stomach
Testis
Thyroid
Uterus
Vagina
Whole Blood

Pathways

PathwaySourceExternal ID
Immune SystemREACTOMER-HSA-168256
Cytokine Signaling in Immune systemREACTOMER-HSA-1280215
Signaling by InterleukinsREACTOMER-HSA-449147

Protein levels (Protein atlas)

Not detected
Low
Medium
High
N/A

References

Pubmed IDYearTitleCitations
162860162005IL-33, an interleukin-1-like cytokine that signals via the IL-1 receptor-related protein ST2 and induces T helper type 2-associated cytokines.1016
208605032010A large-scale, consortium-based genomewide association study of asthma.610
191986102009Sequence variants affecting eosinophil numbers associate with asthma and myocardial infarction.271
191986102009Sequence variants affecting eosinophil numbers associate with asthma and myocardial infarction.271
188278262008The IL-33/ST2 pathway: therapeutic target and novel biomarker.181
188020812008IL-33 induces antigen-specific IL-5+ T cells and promotes allergic-induced airway inflammation independent of IL-4.170
216827362011The genetics of asthma and allergic disease: a 21st century perspective.159
176236482007Soluble ST2 blocks interleukin-33 signaling in allergic airway inflammation.158
203858152010Epithelial-derived IL-33 and its receptor ST2 are dysregulated in ulcerative colitis and in experimental Th1/Th2 driven enteritis.136
198984812009Genetic variants at CD28, PRDM1 and CD2/CD58 are associated with rheumatoid arthritis risk.131

Citation

Dessen P

IL1RL1 (interleukin 1 receptor like 1)

Atlas Genet Cytogenet Oncol Haematol. 2007-02-01

Online version: http://atlasgeneticsoncology.org/gene/46331/il1rl1