IL1RL2 (interleukin 1 receptor like 2)

2014-11-01  

Identity

HGNC
LOCATION
2q12.1
LOCUSID
ALIAS
IL-1Rrp2,IL-36R,IL1R-rp2,IL1RRP2
FUSION GENES

Other Information

Locus ID:

NCBI: 8808
MIM: 604512
HGNC: 5999
Ensembl: ENSG00000115598

Variants:

dbSNP: 8808
ClinVar: 8808
TCGA: ENSG00000115598
COSMIC: IL1RL2

RNA/Proteins

Gene IDTranscript IDUniprot
ENSG00000115598ENST00000264257Q9HB29
ENSG00000115598ENST00000421464C9K0I8
ENSG00000115598ENST00000441515Q9HB29

Expression (GTEx)

0
5
10
15

Pathways

PathwaySourceExternal ID
Immune SystemREACTOMER-HSA-168256
Cytokine Signaling in Immune systemREACTOMER-HSA-1280215
Signaling by InterleukinsREACTOMER-HSA-449147

Protein levels (Protein atlas)

Not detected
Low
Medium
High

References

Pubmed IDYearTitleCitations
223154222012IL-38 binds to the IL-36 receptor and has biological effects on immune cells similar to IL-36 receptor antagonist.68
191805182009Associations of 25 structural, degradative, and inflammatory candidate genes with lumbar disc desiccation, bulging, and height narrowing.29
221442592012Expression of IL-1Rrp2 by human myelomonocytic cells is unique to DCs and facilitates DC maturation by IL-1F8 and IL-1F9.28
202374962010New genetic associations detected in a host response study to hepatitis B vaccine.27
190748852008Genetic variants in apoptosis and immunoregulation-related genes are associated with risk of chronic lymphocytic leukemia.25
259027392015Interleukin-36α axis is modulated in patients with primary Sjögren's syndrome.21
268133442016IL-36α expression is elevated in ulcerative colitis and promotes colonic inflammation.20
203535652010Allelic variants of IL1R1 gene associate with severe hand osteoarthritis.19
276732782017IL-36γ has proinflammatory effects on human endothelial cells.16
208006032010Investigation of genetic susceptibility factors for human longevity - a targeted nonsynonymous SNP study.12

Citation

Dessen P

IL1RL2 (interleukin 1 receptor like 2)

Atlas Genet Cytogenet Oncol Haematol. 2014-11-01

Online version: http://atlasgeneticsoncology.org/gene/64594/il1rl2