IL21 (interleukin 21)

2003-05-01  

Identity

HGNC
LOCATION
4q27
LOCUSID
ALIAS
CVID11,IL-21,Za11

Other Information

Locus ID:

NCBI: 59067
MIM: 605384
HGNC: 6005
Ensembl: ENSG00000138684

Variants:

dbSNP: 59067
ClinVar: 59067
TCGA: ENSG00000138684
COSMIC: IL21

RNA/Proteins

Gene IDTranscript IDUniprot
ENSG00000138684ENST00000611104Q9HBE4
ENSG00000138684ENST00000648588Q9HBE4
ENSG00000138684ENST00000648588A0A224B028

Expression (GTEx)

0
1
2

Pathways

PathwaySourceExternal ID
Cytokine-cytokine receptor interactionKEGGko04060
Jak-STAT signaling pathwayKEGGko04630
Cytokine-cytokine receptor interactionKEGGhsa04060
Jak-STAT signaling pathwayKEGGhsa04630
Inflammatory bowel disease (IBD)KEGGhsa05321
Inflammatory bowel disease (IBD)KEGGko05321
Th17 cell differentiationKEGGko04659
Th17 cell differentiationKEGGhsa04659

References

Pubmed IDYearTitleCitations
241388852013Spatiotemporal dynamics of intratumoral immune cells reveal the immune landscape in human cancer.460
184698002008IL-21 and TGF-beta are required for differentiation of human T(H)17 cells.348
190739672008Shared and distinct genetic variants in type 1 diabetes and celiac disease.249
154944822004Regulation of B cell differentiation and plasma cell generation by IL-21, a novel inducer of Blimp-1 and Bcl-6.217
175584082007A genome-wide association study for celiac disease identifies risk variants in the region harboring IL2 and IL21.209
175584082007A genome-wide association study for celiac disease identifies risk variants in the region harboring IL2 and IL21.209
163395222005IL-21 induces differentiation of human naive and memory B cells into antibody-secreting plasma cells.204
180563612007Cytokine-mediated regulation of human B cell differentiation into Ig-secreting cells: predominant role of IL-21 produced by CXCR5+ T follicular helper cells.184
222795762012Membrane-bound IL-21 promotes sustained ex vivo proliferation of human natural killer cells.156
195922762009Human dendritic cells induce the differentiation of interleukin-21-producing T follicular helper-like cells through interleukin-12.149

Citation

Dessen P

IL21 (interleukin 21)

Atlas Genet Cytogenet Oncol Haematol. 2003-05-01

Online version: http://atlasgeneticsoncology.org/gene/40954/il21