IL25 (interleukin 25)

2015-03-01  

Identity

HGNC
LOCATION
14q11.2
LOCUSID
ALIAS
IL17E

Other Information

Locus ID:

NCBI: 64806
MIM: 605658
HGNC: 13765
Ensembl: ENSG00000166090

Variants:

dbSNP: 64806
ClinVar: 64806
TCGA: ENSG00000166090
COSMIC: IL25

RNA/Proteins

Gene IDTranscript IDUniprot
ENSG00000166090ENST00000329715Q9H293
ENSG00000166090ENST00000397242Q9H293

Expression (GTEx)

0
1
2

Pathways

PathwaySourceExternal ID
Cytokine-cytokine receptor interactionKEGGko04060
Cytokine-cytokine receptor interactionKEGGhsa04060
Immune SystemREACTOMER-HSA-168256
Cytokine Signaling in Immune systemREACTOMER-HSA-1280215
Signaling by InterleukinsREACTOMER-HSA-449147
Interleukin-17 signalingREACTOMER-HSA-448424
IL-17 signaling pathwayKEGGko04657
IL-17 signaling pathwayKEGGhsa04657

Protein levels (Protein atlas)

Not detected
Low
Medium
High

References

Pubmed IDYearTitleCitations
243233572013A role for IL-25 and IL-33-driven type-2 innate lymphoid cells in atopic dermatitis.241
176359552007IL-25 augments type 2 immune responses by enhancing the expansion and functions of TSLP-DC-activated Th2 memory cells.191
238107662013IL-33 is more potent than IL-25 in provoking IL-13-producing nuocytes (type 2 innate lymphoid cells) and airway contraction.131
178892902007Blocking IL-25 prevents airway hyperresponsiveness in allergic asthma.118
243442712014IL-25 and type 2 innate lymphoid cells induce pulmonary fibrosis.94
252730952014Rhinovirus-induced IL-25 in asthma exacerbation drives type 2 immunity and allergic pulmonary inflammation.92
169502782006IL-25 enhances allergic airway inflammation by amplifying a TH2 cell-dependent pathway in mice.73
117148252001Forced expression of murine IL-17E induces growth retardation, jaundice, a Th2-biased response, and multiorgan inflammation in mice.55
122391402002Transgenic overexpression of human IL-17E results in eosinophilia, B-lymphocyte hyperplasia, and altered antibody production.53
215707192011Allergen-induced expression of IL-25 and IL-25 receptor in atopic asthmatic airways and late-phase cutaneous responses.53

Citation

Dessen P

IL25 (interleukin 25)

Atlas Genet Cytogenet Oncol Haematol. 2015-03-01

Online version: http://atlasgeneticsoncology.org/gene/55649/il25