IL27 (interleukin 27)

2007-02-01  

Identity

HGNC
LOCATION
16p12.1
LOCUSID
ALIAS
IL-27,IL-27A,IL27A,IL27p28,IL30,p28

Other Information

Locus ID:

NCBI: 246778
MIM: 608273
HGNC: 19157
Ensembl: ENSG00000197272

Variants:

dbSNP: 246778
ClinVar: 246778
TCGA: ENSG00000197272
COSMIC: IL27

RNA/Proteins

Gene IDTranscript IDUniprot
ENSG00000197272ENST00000356897Q8NEV9
ENSG00000197272ENST00000568075H3BQY2

Expression (GTEx)

0
1
2
3
4
5
6
7
8
9

Pathways

PathwaySourceExternal ID
Immune SystemREACTOMER-HSA-168256
Cytokine Signaling in Immune systemREACTOMER-HSA-1280215
Signaling by InterleukinsREACTOMER-HSA-449147
Interleukin-6 family signalingREACTOMER-HSA-6783589
IL-6-type cytokine receptor ligand interactionsREACTOMER-HSA-6788467

Protein levels (Protein atlas)

Not detected
Low
Medium
High

References

Pubmed IDYearTitleCitations
194304802009Genome-wide association study and meta-analysis find that over 40 loci affect risk of type 1 diabetes.655
121216602002IL-27, a heterodimeric cytokine composed of EBI3 and p28 protein, induces proliferation of naive CD4+ T cells.396
166707652006The IL-23/IL-17 axis in inflammation.235
147646902004WSX-1 and glycoprotein 130 constitute a signal-transducing receptor for IL-27.213
146573532003IL-27 regulates IL-12 responsiveness of naive CD4+ T cells through Stat1-dependent and -independent mechanisms.142
177034122007Genetic susceptibility to respiratory syncytial virus bronchiolitis is predominantly associated with innate immune genes.100
213572662011IL-27 and IL-21 are associated with T cell IL-10 responses in human visceral leishmaniasis.71
201767342010Comparative genetic analysis of inflammatory bowel disease and type 1 diabetes implicates multiple loci with opposite effects.66
184247562008IL-27 activates human monocytes via STAT1 and suppresses IL-10 production but the inflammatory functions of IL-27 are abrogated by TLRs and p38.48
220211942012Genome-wide methylation profiling in Crohn's disease identifies altered epigenetic regulation of key host defense mechanisms including the Th17 pathway.47

Citation

Dessen P

IL27 (interleukin 27)

Atlas Genet Cytogenet Oncol Haematol. 2007-02-01

Online version: http://atlasgeneticsoncology.org/gene/46464/il27