IL27RA (interleukin 27 receptor subunit alpha)

2007-02-01 Affiliation

Identity

HGNC

IL27RA

LOCATION

19p13.12

LOCUSID

9466

ALIAS

CRL1,IL-27RA,IL27R,TCCR,WSX1,zcytor1

FUSION GENES

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Non-annotated gene. Preliminary data : if you are an author who wish to write a full paper/card on this gene, contribute in submission tool

Other Information

Locus ID:

NCBI: 9466
MIM: 605350
HGNC: 17290
Ensembl: ENSG00000104998

Variants:

dbSNP: 9466
ClinVar: 9466
TCGA: ENSG00000104998
COSMIC: IL27RA

RNA/Proteins

Gene ID	Transcript ID	Uniprot
ENSG00000104998	ENST00000263379	Q6UWB1

Expression (GTEx)

Adipose - Subcutaneous

Adipose - Visceral

Adrenal Gland

Artery - Aorta

Artery - Tibial

Bladder

Brain - Amygdala

Brain - Anterior cingulate cortex

Brain - Caudate

Brain - Cerebellar Hemisphere

Brain - Cerebellum

Brain - Cortex

Brain - Frontal Cortex

Brain - Hippocampus

Brain - Hypothalamus

Brain - Nucleus accumbens

Brain - Putamen

Brain - Spinal cord

Brain - Substantia nigra

Breast - Mammary Tissue

Cells - Cultured fibroblasts

Cells - EBV - transformed lymphocytes

Cervix - Ectocervix

Cervix - Endocervix

Colon - Sigmoid

Colon - Transverse

Esophagus - Gastroesophageal Junction

Esophagus - Mucosa

Esophagus - Muscularis

Fallopian Tube

Heart - Atrial Appendage

Heart - Left Ventricle

Kidney - Cortex

Kidney - Medulla

Liver

Lung

Minor Salivary Gland

Muscle - Skeletal

Nerve - Tibial

Ovary

Pancreas

Pituitary

Prostate

Skin - Not Sun Exposed

Skin - Sun Exposed

Small Intestine - Terminal Ileum

Spleen

Stomach

Testis

Thyroid

Uterus

Vagina

Whole Blood

Pathways

Pathway	Source	External ID
Jak-STAT signaling pathway	KEGG	ko04630
Jak-STAT signaling pathway	KEGG	hsa04630
Immune System	REACTOME	R-HSA-168256
Cytokine Signaling in Immune system	REACTOME	R-HSA-1280215
Signaling by Interleukins	REACTOME	R-HSA-449147
Interleukin-6 family signaling	REACTOME	R-HSA-6783589
IL-6-type cytokine receptor ligand interactions	REACTOME	R-HSA-6788467
Th17 cell differentiation	KEGG	ko04659
Th17 cell differentiation	KEGG	hsa04659

References

Pubmed ID	Year	Title	Citations
14764690	2004	WSX-1 and glycoprotein 130 constitute a signal-transducing receptor for IL-27.	213
12734330	2003	Cutting edge: role of IL-27/WSX-1 signaling for induction of T-bet through activation of STAT1 during initial Th1 commitment.	172
17703412	2007	Genetic susceptibility to respiratory syncytial virus bronchiolitis is predominantly associated with innate immune genes.	100
19386761	2009	Humanin inhibits neuronal cell death by interacting with a cytokine receptor complex or complexes involving CNTF receptor alpha/WSX-1/gp130.	47
26282876	2015	Interleukin 27R regulates CD4+ T cell phenotype and impacts protective immunity during Mycobacterium tuberculosis infection.	27
19258923	2009	Genetic susceptibility to respiratory syncytial virus bronchiolitis in preterm children is associated with airway remodeling genes and innate immune genes.	26
18003935	2007	Transformation of hematopoietic cells and activation of JAK2-V617F by IL-27R, a component of a heterodimeric type I cytokine receptor.	22
20503287	2010	Interleukin-9 polymorphism in infants with respiratory syncytial virus infection: an opposite effect in boys and girls.	17
19549909	2009	Expression of WSX1 in tumors sensitizes IL-27 signaling-independent natural killer cell surveillance.	15
22936014	2013	Genome-wide profiling of methylation identifies novel targets with aberrant hypermethylation and reduced expression in low-risk myelodysplastic syndromes.	14

Citation

Dessen P

IL27RA (interleukin 27 receptor subunit alpha)

Atlas Genet Cytogenet Oncol Haematol. 2007-02-01

Online version: http://atlasgeneticsoncology.org/gene/50022/il27ra