IL33 (interleukin 33)

2009-02-01  

Identity

HGNC
LOCATION
9p24.1
LOCUSID
ALIAS
C9orf26,DVS27,IL1F11,NF-HEV,NFEHEV

Other Information

Locus ID:

NCBI: 90865
MIM: 608678
HGNC: 16028
Ensembl: ENSG00000137033

Variants:

dbSNP: 90865
ClinVar: 90865
TCGA: ENSG00000137033
COSMIC: IL33

RNA/Proteins

Gene IDTranscript IDUniprot
ENSG00000137033ENST00000381434O95760
ENSG00000137033ENST00000417746O95760
ENSG00000137033ENST00000456383O95760
ENSG00000137033ENST00000611532O95760

Expression (GTEx)

0
10
20
30
40
50
60
70

Pathways

PathwaySourceExternal ID
Cytosolic DNA-sensing pathwayKEGGko04623
Cytosolic DNA-sensing pathwayKEGGhsa04623
Influenza AKEGGko05164
Influenza AKEGGhsa05164
Metabolism of proteinsREACTOMER-HSA-392499
Post-translational protein modificationREACTOMER-HSA-597592
Immune SystemREACTOMER-HSA-168256
Cytokine Signaling in Immune systemREACTOMER-HSA-1280215
Signaling by InterleukinsREACTOMER-HSA-449147
DeubiquitinationREACTOMER-HSA-5688426
Ub-specific processing proteasesREACTOMER-HSA-5689880

Protein levels (Protein atlas)

Not detected
Low
Medium
High

References

Pubmed IDYearTitleCitations
162860162005IL-33, an interleukin-1-like cytokine that signals via the IL-1 receptor-related protein ST2 and induces T helper type 2-associated cytokines.1016
208605032010A large-scale, consortium-based genomewide association study of asthma.610
188365282008The IL-1-like cytokine IL-33 is constitutively expressed in the nucleus of endothelial cells and epithelial cells in vivo: a novel 'alarmin'?338
171854182007IL-33, the IL-1-like cytokine ligand for ST2 receptor, is a chromatin-associated nuclear factor in vivo.292
191986102009Sequence variants affecting eosinophil numbers associate with asthma and myocardial infarction.271
191986102009Sequence variants affecting eosinophil numbers associate with asthma and myocardial infarction.271
243233572013A role for IL-25 and IL-33-driven type-2 innate lymphoid cells in atopic dermatitis.241
198411662009IL-33 amplifies the polarization of alternatively activated macrophages that contribute to airway inflammation.223
233639802013TSLP elicits IL-33-independent innate lymphoid cell responses to promote skin inflammation.216
194396632009The IL-1-like cytokine IL-33 is inactivated after maturation by caspase-1.211

Citation

Dessen P

IL33 (interleukin 33)

Atlas Genet Cytogenet Oncol Haematol. 2009-02-01

Online version: http://atlasgeneticsoncology.org/gene/50672/il33