IL36RN (interleukin 36 receptor antagonist)

2016-12-01  

Identity

HGNC
IL36RN
LOCATION
2q14.1
LOCUSID
26525
ALIAS
FIL1,FIL1(DELTA),FIL1D,IL-36Ra,IL1F5,IL1HY1,IL1L1,IL1RP3,IL36RA,PSORP,PSORS14

Other Information

Locus ID:

NCBI: 26525
MIM: 605507
HGNC: 15561
Ensembl: ENSG00000136695

Variants:

dbSNP: 26525
ClinVar: 26525
TCGA: ENSG00000136695
COSMIC: IL36RN

RNA/Proteins

Gene IDTranscript IDUniprot
ENSG00000136695ENST00000346807Q9UBH0
ENSG00000136695ENST00000346807A0A024R518
ENSG00000136695ENST00000393200Q9UBH0
ENSG00000136695ENST00000393200A0A024R518
ENSG00000136695ENST00000437409C9JTH1
ENSG00000136695ENST00000514072U3KPW9

Expression (GTEx)

0
10
20
30
40
50
60
70
80
90
Adipose - Subcutaneous
Adipose - Visceral
Adrenal Gland
Artery - Aorta
Artery - Tibial
Bladder
Brain - Amygdala
Brain - Anterior cingulate cortex
Brain - Caudate
Brain - Cerebellar Hemisphere
Brain - Cerebellum
Brain - Cortex
Brain - Frontal Cortex
Brain - Hippocampus
Brain - Hypothalamus
Brain - Nucleus accumbens
Brain - Putamen
Brain - Spinal cord
Brain - Substantia nigra
Breast - Mammary Tissue
Cells - Cultured fibroblasts
Cells - EBV - transformed lymphocytes
Cervix - Ectocervix
Cervix - Endocervix
Colon - Sigmoid
Colon - Transverse
Esophagus - Gastroesophageal Junction
Esophagus - Mucosa
Esophagus - Muscularis
Fallopian Tube
Heart - Atrial Appendage
Heart - Left Ventricle
Kidney - Cortex
Kidney - Medulla
Liver
Lung
Minor Salivary Gland
Muscle - Skeletal
Nerve - Tibial
Ovary
Pancreas
Pituitary
Prostate
Skin - Not Sun Exposed
Skin - Sun Exposed
Small Intestine - Terminal Ileum
Spleen
Stomach
Testis
Thyroid
Uterus
Vagina
Whole Blood

References

Pubmed IDYearTitleCitations
218394232011Mutations in IL36RN/IL1F5 are associated with the severe episodic inflammatory skin disease known as generalized pustular psoriasis.102
199131212009Gene-centric association signals for lipids and apolipoproteins identified via the HumanCVD BeadChip.85
212425152011IL-1F5, -F6, -F8, and -F9: a novel IL-1 family signaling system that is active in psoriasis and promotes keratinocyte antimicrobial peptide expression.83
219656792011Interleukin-36 (IL-36) ligands require processing for full agonist (IL-36α, IL-36β, and IL-36γ) or antagonist (IL-36Ra) activity.82
248294172014IL-36 promotes myeloid cell infiltration, activation, and inflammatory activity in skin.70
223154222012IL-38 binds to the IL-36 receptor and has biological effects on immune cells similar to IL-36 receptor antagonist.68
114663632001Two novel IL-1 family members, IL-1 delta and IL-1 epsilon, function as an antagonist and agonist of NF-kappa B activation through the orphan IL-1 receptor-related protein 2.65
179751192008Association of gene variants with incident myocardial infarction in the Cardiovascular Health Study.65
203796142010Personalized smoking cessation: interactions between nicotine dose, dependence and quit-success genotype score.62
169180242006Association between the interleukin-1 family gene cluster and psoriatic arthritis.32

Citation

Dessen P

IL36RN (interleukin 36 receptor antagonist)

Atlas Genet Cytogenet Oncol Haematol. 2016-12-01

Online version: http://atlasgeneticsoncology.org/gene/56638/il36rn