Identity
HGNC
LOCATION
2q14.1
LOCUSID
ALIAS
FIL1,FIL1(ZETA),FIL1Z,IL-1F7,IL-1H,IL-1H4,IL-1RP1,IL-23,IL-37,IL1F7,IL1H4,IL1RP1
Non-annotated gene. Preliminary data : if you are an author who wish to write a full paper/card on this gene, contribute in submission tool
Other Information
Locus ID:
NCBI: 27178
MIM: 605510
HGNC: 15563
Ensembl: ENSG00000125571
Variants:
dbSNP: 27178
ClinVar: 27178
TCGA: ENSG00000125571
COSMIC: IL37
RNA/Proteins
Expression (GTEx)
Pathways
| Pathway | Source | External ID |
|---|---|---|
| Immune System | REACTOME | R-HSA-168256 |
| Cytokine Signaling in Immune system | REACTOME | R-HSA-1280215 |
| Signaling by Interleukins | REACTOME | R-HSA-449147 |
Protein levels (Protein atlas)
References
| Pubmed ID | Year | Title | Citations |
|---|---|---|---|
| 38091678 | 2024 | Interleukin-37 relieves PM2.5-triggered lung injury by inhibiting autophagy through the AKT/mTOR signaling pathway in vivo and in vitro. | 1 |
| 38412100 | 2024 | IL-37 dampens immunosuppressive functions of MDSCs via metabolic reprogramming in the tumor microenvironment. | 2 |
| 38513665 | 2024 | Epithelial-derived interleukin-23 promotes oral mucosal immunopathology. | 0 |
| 38091678 | 2024 | Interleukin-37 relieves PM2.5-triggered lung injury by inhibiting autophagy through the AKT/mTOR signaling pathway in vivo and in vitro. | 1 |
| 38412100 | 2024 | IL-37 dampens immunosuppressive functions of MDSCs via metabolic reprogramming in the tumor microenvironment. | 2 |
| 38513665 | 2024 | Epithelial-derived interleukin-23 promotes oral mucosal immunopathology. | 0 |
| 35622271 | 2023 | Circulating interleukin-37 declines with aging in healthy humans: relations to healthspan indicators and IL37 gene SNPs. | 4 |
| 36326182 | 2023 | Interleukin-37 suppresses the cytotoxicity of hepatitis B virus peptides-induced CD8+ T cells in patients with acute hepatitis B. | 1 |
| 36476991 | 2023 | Effect of exogenous IL-37 on immune cells from a patient carrying a potential IL37 loss-of-function variant: A case study. | 0 |
| 36834391 | 2023 | A Critical Appraisal of the Diagnostic and Prognostic Utility of the Anti-Inflammatory Marker IL-37 in a Clinical Setting: A Case Study of Patients with Diabetes Type 2. | 1 |
| 36853287 | 2023 | Polymorphism Analysis of Interleukin-18 and Interleukin-37 Genes in Hepatitis B Infections with Different Outcomes: A Preliminary Report from an Iranian Population. | 0 |
| 37030535 | 2023 | Interleukin-23 mediates the reduction of GADD45a expression to attenuate oxidative stress-induced cellular senescence in human fibroblasts. | 0 |
| 37031465 | 2023 | Interleukin -37 in rheumatoid arthritis: Correlation with clinical severity and genetic polymorphisms in Mosul city, Iraq. | 1 |
| 37061279 | 2023 | Relative CTLA-4, PTPN-22, and interleukin 37 mRNA expressions in patients with lupus nephritis. | 1 |
| 37069321 | 2023 | IL-12 and IL-23 pathway inhibition in inflammatory bowel disease. | 17 |
Citation
Dessen P
IL37 (interleukin 37)
Atlas Genet Cytogenet Oncol Haematol. 2011-06-01
Online version: http://atlasgeneticsoncology.org/gene/52265/il37
