Identity
HGNC
LOCATION
7q32.1
LOCUSID
ALIAS
IMPD,IMPD1,IMPDH-I,LCA11,RP10,sWSS2608
FUSION GENES
Non-annotated gene. Preliminary data : if you are an author who wish to write a full paper/card on this gene, contribute in submission tool
Other Information
Locus ID:
NCBI: 3614
MIM: 146690
HGNC: 6052
Ensembl: ENSG00000106348
Variants:
dbSNP: 3614
ClinVar: 3614
TCGA: ENSG00000106348
COSMIC: IMPDH1
RNA/Proteins
Expression (GTEx)
Pathways
Protein levels (Protein atlas)
PharmGKB
| Entity ID | Name | Type | Evidence | Association | PK | PD | PMIDs |
|---|---|---|---|---|---|---|---|
| PA133888799 | Organ Transplantation | Disease | ClinicalAnnotation | associated | PD | 17851563, 20136638, 20649757, 20679962, 21142914, 22960765 | |
| PA164748728 | mycophenolic acid | Chemical | Pathway | associated | 24220207 | ||
| PA165817016 | Kidney Transplantation | Disease | ClinicalAnnotation | associated | PD | 17851563, 20136638, 20679962, 21142914, 22960765 | |
| PA444773 | Leukopenia | Disease | ClinicalAnnotation | associated | PD | 20679962, 21142914 | |
| PA450566 | mycophenolate mofetil | Chemical | ClinicalAnnotation | associated | PD | 17851563, 20136638, 20649757, 20679962, 21142914, 22960765 |
References
| Pubmed ID | Year | Title | Citations |
|---|---|---|---|
| 36629054 | 2023 | c-Myc-IMPDH1/2 axis promotes tumourigenesis by regulating GTP metabolic reprogramming. | 6 |
| 37259572 | 2023 | IMPDH1-associated autosomal dominant retinitis pigmentosa: natural history of novel variant Lys314Gln and a comprehensive literature search. | 0 |
| 36629054 | 2023 | c-Myc-IMPDH1/2 axis promotes tumourigenesis by regulating GTP metabolic reprogramming. | 6 |
| 37259572 | 2023 | IMPDH1-associated autosomal dominant retinitis pigmentosa: natural history of novel variant Lys314Gln and a comprehensive literature search. | 0 |
| 35013599 | 2022 | IMPDH1 retinal variants control filament architecture to tune allosteric regulation. | 22 |
| 35403278 | 2022 | Inosine monophosphate dehydrogenase type1 sustains tumor growth in hepatocellular carcinoma. | 1 |
| 36494680 | 2022 | MYBL2 regulates de novo purine synthesis by transcriptionally activating IMPDH1 in hepatocellular carcinoma cells. | 3 |
| 36618420 | 2022 | IMPDH1, a prognostic biomarker and immunotherapy target that correlates with tumor immune microenvironment in pan-cancer and hepatocellular carcinoma. | 3 |
| 35013599 | 2022 | IMPDH1 retinal variants control filament architecture to tune allosteric regulation. | 22 |
| 35403278 | 2022 | Inosine monophosphate dehydrogenase type1 sustains tumor growth in hepatocellular carcinoma. | 1 |
| 36494680 | 2022 | MYBL2 regulates de novo purine synthesis by transcriptionally activating IMPDH1 in hepatocellular carcinoma cells. | 3 |
| 36618420 | 2022 | IMPDH1, a prognostic biomarker and immunotherapy target that correlates with tumor immune microenvironment in pan-cancer and hepatocellular carcinoma. | 3 |
| 34643616 | 2021 | Inosine 5'-Monophosphate Dehydrogenase Cytoophidia Neighbor Insulin Granules in Pancreatic β Cells. | 0 |
| 34643616 | 2021 | Inosine 5'-Monophosphate Dehydrogenase Cytoophidia Neighbor Insulin Granules in Pancreatic β Cells. | 0 |
| 31883196 | 2020 | IMP dehydrogenase rod/ring structures in acral melanomas. | 6 |
Citation
Dessen P
IMPDH1 (inosine monophosphate dehydrogenase 1)
Atlas Genet Cytogenet Oncol Haematol. 2006-10-01
Online version: http://atlasgeneticsoncology.org/gene/43316/impdh1
