INCENP (inner centromere protein)

2006-10-01  

Identity

HGNC
LOCATION
11q12.3
LOCUSID
ALIAS
-

Other Information

Locus ID:

NCBI: 3619
MIM: 604411
HGNC: 6058
Ensembl: ENSG00000149503

Variants:

dbSNP: 3619
ClinVar: 3619
TCGA: ENSG00000149503
COSMIC: INCENP

RNA/Proteins

Gene IDTranscript IDUniprot
ENSG00000149503ENST00000278849Q9NQS7
ENSG00000149503ENST00000394818Q9NQS7
ENSG00000149503ENST00000533896E9PM67

Expression (GTEx)

0
5
10
15
20
25
30
35
40
45
50

Pathways

PathwaySourceExternal ID
Metabolism of proteinsREACTOMER-HSA-392499
Post-translational protein modificationREACTOMER-HSA-597592
SUMOylationREACTOMER-HSA-2990846
SUMO E3 ligases SUMOylate target proteinsREACTOMER-HSA-3108232
Signal TransductionREACTOMER-HSA-162582
Signaling by Rho GTPasesREACTOMER-HSA-194315
RHO GTPase EffectorsREACTOMER-HSA-195258
RHO GTPases Activate ForminsREACTOMER-HSA-5663220
Cell CycleREACTOMER-HSA-1640170
Cell Cycle, MitoticREACTOMER-HSA-69278
M PhaseREACTOMER-HSA-68886
Mitotic PrometaphaseREACTOMER-HSA-68877
Resolution of Sister Chromatid CohesionREACTOMER-HSA-2500257
Mitotic Metaphase and AnaphaseREACTOMER-HSA-2555396
Mitotic AnaphaseREACTOMER-HSA-68882
Separation of Sister ChromatidsREACTOMER-HSA-2467813
SUMOylation of DNA replication proteinsREACTOMER-HSA-4615885

Protein levels (Protein atlas)

Not detected
Low
Medium
High

References

Pubmed IDYearTitleCitations
129257662003Exploring the functional interactions between Aurora B, INCENP, and survivin in mitosis.199
179567292007Structure of a Survivin-Borealin-INCENP core complex reveals how chromosomal passengers travel together.126
176238122007Centromere RNA is a key component for the assembly of nucleoproteins at the nucleolus and centromere.98
165716742006Centromere targeting of the chromosomal passenger complex requires a ternary subcomplex of Borealin, Survivin, and the N-terminal domain of INCENP.74
162399252006Survivin mediates targeting of the chromosomal passenger complex to the centromere and midbody.70
163780982006Complex formation of Plk1 and INCENP required for metaphase-anaphase transition.69
213461952011Mitotic centromeric targeting of HP1 and its binding to Sgo1 are dispensable for sister-chromatid cohesion in human cells.37
206196512010Relocation of the chromosomal passenger complex prevents mitotic checkpoint engagement at anaphase.36
153160252004Direct association with inner centromere protein (INCENP) activates the novel chromosomal passenger protein, Aurora-C.32
157967172005Recruitment of MKLP1 to the spindle midzone/midbody by INCENP is essential for midbody formation and completion of cytokinesis in human cells.31

Citation

Dessen P

INCENP (inner centromere protein)

Atlas Genet Cytogenet Oncol Haematol. 2006-10-01

Online version: http://atlasgeneticsoncology.org/gene/43317/incenp