INHBA (inhibin subunit beta A)

2003-06-01  

Identity

HGNC
INHBA
LOCATION
7p14.1
LOCUSID
3624
ALIAS
EDF,FRP

Other Information

Locus ID:

NCBI: 3624
MIM: 147290
HGNC: 6066
Ensembl: ENSG00000122641

Variants:

dbSNP: 3624
ClinVar: 3624
TCGA: ENSG00000122641
COSMIC: INHBA

RNA/Proteins

Gene IDTranscript IDUniprot
ENSG00000122641ENST00000242208P08476
ENSG00000122641ENST00000242208A4D1W7
ENSG00000122641ENST00000442711P08476
ENSG00000122641ENST00000442711A4D1W7
ENSG00000122641ENST00000638023P08476
ENSG00000122641ENST00000638023A4D1W7

Expression (GTEx)

0
5
10
15
20
25
Adipose - Subcutaneous
Adipose - Visceral
Adrenal Gland
Artery - Aorta
Artery - Tibial
Bladder
Brain - Amygdala
Brain - Anterior cingulate cortex
Brain - Caudate
Brain - Cerebellar Hemisphere
Brain - Cerebellum
Brain - Cortex
Brain - Frontal Cortex
Brain - Hippocampus
Brain - Hypothalamus
Brain - Nucleus accumbens
Brain - Putamen
Brain - Spinal cord
Brain - Substantia nigra
Breast - Mammary Tissue
Cells - Cultured fibroblasts
Cells - EBV - transformed lymphocytes
Cervix - Ectocervix
Cervix - Endocervix
Colon - Sigmoid
Colon - Transverse
Esophagus - Gastroesophageal Junction
Esophagus - Mucosa
Esophagus - Muscularis
Fallopian Tube
Heart - Atrial Appendage
Heart - Left Ventricle
Kidney - Cortex
Kidney - Medulla
Liver
Lung
Minor Salivary Gland
Muscle - Skeletal
Nerve - Tibial
Ovary
Pancreas
Pituitary
Prostate
Skin - Not Sun Exposed
Skin - Sun Exposed
Small Intestine - Terminal Ileum
Spleen
Stomach
Testis
Thyroid
Uterus
Vagina
Whole Blood

Pathways

PathwaySourceExternal ID
Cytokine-cytokine receptor interactionKEGGko04060
TGF-beta signaling pathwayKEGGko04350
Cytokine-cytokine receptor interactionKEGGhsa04060
TGF-beta signaling pathwayKEGGhsa04350
Signaling pathways regulating pluripotency of stem cellsKEGGhsa04550
Signaling pathways regulating pluripotency of stem cellsKEGGko04550
Activin signalingKEGGhsa_M00681
Activin signalingKEGGM00681
Metabolism of proteinsREACTOMER-HSA-392499
Peptide hormone metabolismREACTOMER-HSA-2980736
Peptide hormone biosynthesisREACTOMER-HSA-209952
Glycoprotein hormonesREACTOMER-HSA-209822
Signal TransductionREACTOMER-HSA-162582
Signaling by ActivinREACTOMER-HSA-1502540
Antagonism of Activin by FollistatinREACTOMER-HSA-2473224

PharmGKB

Entity IDNameTypeEvidenceAssociationPKPDPMIDs
PA130232992bevacizumabChemicalVariantAnnotationnot associatedPD29852030
PA164746012ranibizumabChemicalVariantAnnotationnot associatedPD29852030

References

Pubmed IDYearTitleCitations
172046042007Activin a efficiently specifies definitive endoderm from human embryonic stem cells only when phosphatidylinositol 3-kinase signaling is suppressed.150
187191012008Highly efficient differentiation of hESCs to functional hepatic endoderm requires ActivinA and Wnt3a signaling.133
211324022012Upregulated INHBA expression is associated with poor survival in gastric cancer.69
203796142010Personalized smoking cessation: interactions between nicotine dose, dependence and quit-success genotype score.62
243788732014Elevated expression of activins promotes muscle wasting and cachexia.46
152922562004Proteomic analysis of articular cartilage shows increased type II collagen synthesis in osteoarthritis and expression of inhibin betaA (activin A), a regulatory molecule for chondrocytes.45
185351062008Differential antagonism of activin, myostatin and growth and differentiation factor 11 by wild-type and mutant follistatin.45
273764692016Activin A programs the differentiation of human TFH cells.43
180774492008Hypoxia promotes the differentiated human articular chondrocyte phenotype through SOX9-dependent and -independent pathways.40
202003322010Family-based analysis of candidate genes for polycystic ovary syndrome.40

Citation

Dessen P

INHBA (inhibin subunit beta A)

Atlas Genet Cytogenet Oncol Haematol. 2003-06-01

Online version: http://atlasgeneticsoncology.org/gene/40980/inhba