INSIG2 (insulin induced gene 2)

2008-07-01  

Identity

HGNC
LOCATION
2q14.1
LOCUSID
ALIAS
INSIG-2
FUSION GENES

Other Information

Locus ID:

NCBI: 51141
MIM: 608660
HGNC: 20452
Ensembl: ENSG00000125629

Variants:

dbSNP: 51141
ClinVar: 51141
TCGA: ENSG00000125629
COSMIC: INSIG2

RNA/Proteins

Gene IDTranscript IDUniprot
ENSG00000125629ENST00000245787Q9Y5U4
ENSG00000125629ENST00000245787A0A024RAI2
ENSG00000125629ENST00000411929F8WCG8
ENSG00000125629ENST00000614681A0A0C4DGZ4

Expression (GTEx)

0
5
10
15
20
25
30
35
40
45

Pathways

PathwaySourceExternal ID
MetabolismREACTOMER-HSA-1430728
Metabolism of lipids and lipoproteinsREACTOMER-HSA-556833
Regulation of cholesterol biosynthesis by SREBP (SREBF)REACTOMER-HSA-1655829

Protein levels (Protein atlas)

Not detected
Low
Medium
High

PharmGKB

Entity IDNameTypeEvidenceAssociationPKPDPMIDs
PA162370415Metabolic SyndromeDiseaseVariantAnnotationassociatedPD20877301
PA447216SchizophreniaDiseaseClinicalAnnotation, VariantAnnotationassociatedPD18195716, 20373477, 20877301
PA452233antipsychoticsChemicalClinicalAnnotation, VariantAnnotationassociatedPD18195716, 20373477, 20877301

References

Pubmed IDYearTitleCitations
166142262006A common genetic variant is associated with adult and childhood obesity.226
174289202007Sterol-regulated transport of SREBPs from endoplasmic reticulum to Golgi: oxysterols block transport by binding to Insig.167
199131212009Gene-centric association signals for lipids and apolipoproteins identified via the HumanCVD BeadChip.85
174656812007The association of a SNP upstream of INSIG2 with body mass index is reproduced in several but not all cohorts.64
174656812007The association of a SNP upstream of INSIG2 with body mass index is reproduced in several but not all cohorts.64
208161952010Analyses of shared genetic factors between asthma and obesity in children.43
181957162009Association between the insulin-induced gene 2 (INSIG2) and weight gain in a German sample of antipsychotic-treated schizophrenic patients: perturbation of SREBP-controlled lipogenesis in drug-related metabolic adverse effects?30
188391342008Assessing gene-treatment interactions at the FTO and INSIG2 loci on obesity-related traits in the Diabetes Prevention Program.30
188391342008Assessing gene-treatment interactions at the FTO and INSIG2 loci on obesity-related traits in the Diabetes Prevention Program.30
205389602010A candidate gene study of obstructive sleep apnea in European Americans and African Americans.30

Citation

Dessen P

INSIG2 (insulin induced gene 2)

Atlas Genet Cytogenet Oncol Haematol. 2008-07-01

Online version: http://atlasgeneticsoncology.org/gene/50205/insig2