INSL3 (insulin like 3)

2007-02-01  

Identity

HGNC
INSL3
LOCATION
19p13.11
LOCUSID
3640
ALIAS
RLF,RLNL,ley-I-L
FUSION GENES
Show Gene Fusions

Other Information

Locus ID:

NCBI: 3640
MIM: 146738
HGNC: 6086
Ensembl: ENSG00000248099

Variants:

dbSNP: 3640
ClinVar: 3640
TCGA: ENSG00000248099
COSMIC: INSL3

RNA/Proteins

Gene IDTranscript IDUniprot
ENSG00000248099ENST00000317306P51460
ENSG00000248099ENST00000379695P51460
ENSG00000248099ENST00000598577M0QXQ3

Expression (GTEx)

0
50
100
150
200
250
Adipose - Subcutaneous
Adipose - Visceral
Adrenal Gland
Artery - Aorta
Artery - Tibial
Bladder
Brain - Amygdala
Brain - Anterior cingulate cortex
Brain - Caudate
Brain - Cerebellar Hemisphere
Brain - Cerebellum
Brain - Cortex
Brain - Frontal Cortex
Brain - Hippocampus
Brain - Hypothalamus
Brain - Nucleus accumbens
Brain - Putamen
Brain - Spinal cord
Brain - Substantia nigra
Breast - Mammary Tissue
Cells - Cultured fibroblasts
Cells - EBV - transformed lymphocytes
Cervix - Ectocervix
Cervix - Endocervix
Colon - Sigmoid
Colon - Transverse
Esophagus - Gastroesophageal Junction
Esophagus - Mucosa
Esophagus - Muscularis
Fallopian Tube
Heart - Atrial Appendage
Heart - Left Ventricle
Kidney - Cortex
Kidney - Medulla
Liver
Lung
Minor Salivary Gland
Muscle - Skeletal
Nerve - Tibial
Ovary
Pancreas
Pituitary
Prostate
Skin - Not Sun Exposed
Skin - Sun Exposed
Small Intestine - Terminal Ileum
Spleen
Stomach
Testis
Thyroid
Uterus
Vagina
Whole Blood

Pathways

PathwaySourceExternal ID
Signal TransductionREACTOMER-HSA-162582
Signaling by GPCRREACTOMER-HSA-372790
GPCR ligand bindingREACTOMER-HSA-500792
Class A/1 (Rhodopsin-like receptors)REACTOMER-HSA-373076
Peptide ligand-binding receptorsREACTOMER-HSA-375276
Relaxin receptorsREACTOMER-HSA-444821
GPCR downstream signalingREACTOMER-HSA-388396
G alpha (s) signalling eventsREACTOMER-HSA-418555

Protein levels (Protein atlas)

Not detected
Low
Medium
High
cerebral cortex
cerebellum
hippocampus
caudate
thyroid gland
parathyroid gland
adrenal gland
nasopharynx
bronchus
lung
oral mucosa
salivary gland
esophagus
stomach 1
stomach 2
duodenum
small intestine
colon
rectum
liver
gallbladder
pancreas
kidney
urinary bladder
testis
epididymis
seminal vesicle
prostate
vagina
ovary
fallopian tube
endometrium 1
endometrium 2
cervix, uterine
placenta
breast
heart muscle
smooth muscle
skeletal muscle
soft tissue 1
soft tissue 2
adipose tissue
skin 1
skin 2
appendix
spleen
lymph node
tonsil
bone marrow

References

Pubmed IDYearTitleCitations
103912201999Cryptorchidism in mice mutant for Insl3.84
202003322010Family-based analysis of candidate genes for polycystic ovary syndrome.40
190179132008Genetic alterations associated with cryptorchidism.29
190179132008Genetic alterations associated with cryptorchidism.29
184333022008Mutations in the insulin-like factor 3 receptor are associated with osteoporosis.22
176664782007Insulin-like factor 3 levels in cord blood and serum from children: effects of age, postnatal hypothalamic-pituitary-gonadal axis activation, and cryptorchidism.20
194235402009Common variation in genes related to innate immunity and risk of adult glioma.19
193298052009Biology of insulin-like factor 3 in human reproduction.18
157088462005LGR8 signal activation by the relaxin-like factor.16
168679802006Solution structure and characterization of the LGR8 receptor binding surface of insulin-like peptide 3.16

Citation

Dessen P

INSL3 (insulin like 3)

Atlas Genet Cytogenet Oncol Haematol. 2007-02-01

Online version: http://atlasgeneticsoncology.org/gene/45583/insl3