INSL5 (insulin like 5)

2013-11-01  

Identity

HGNC
INSL5
LOCATION
1p31.3
LOCUSID
10022
ALIAS
PRO182,UNQ156

Other Information

Locus ID:

NCBI: 10022
MIM: 606413
HGNC: 6088
Ensembl: ENSG00000172410

Variants:

dbSNP: 10022
ClinVar: 10022
TCGA: ENSG00000172410
COSMIC: INSL5

RNA/Proteins

Gene IDTranscript IDUniprot
ENSG00000172410ENST00000304526Q9Y5Q6

Expression (GTEx)

0
1
Adipose - Subcutaneous
Adipose - Visceral
Adrenal Gland
Artery - Aorta
Artery - Tibial
Bladder
Brain - Amygdala
Brain - Anterior cingulate cortex
Brain - Caudate
Brain - Cerebellar Hemisphere
Brain - Cerebellum
Brain - Cortex
Brain - Frontal Cortex
Brain - Hippocampus
Brain - Hypothalamus
Brain - Nucleus accumbens
Brain - Putamen
Brain - Spinal cord
Brain - Substantia nigra
Breast - Mammary Tissue
Cells - Cultured fibroblasts
Cells - EBV - transformed lymphocytes
Cervix - Ectocervix
Cervix - Endocervix
Colon - Sigmoid
Colon - Transverse
Esophagus - Gastroesophageal Junction
Esophagus - Mucosa
Esophagus - Muscularis
Fallopian Tube
Heart - Atrial Appendage
Heart - Left Ventricle
Kidney - Cortex
Kidney - Medulla
Liver
Lung
Minor Salivary Gland
Muscle - Skeletal
Nerve - Tibial
Ovary
Pancreas
Pituitary
Prostate
Skin - Not Sun Exposed
Skin - Sun Exposed
Small Intestine - Terminal Ileum
Spleen
Stomach
Testis
Thyroid
Uterus
Vagina
Whole Blood

Pathways

PathwaySourceExternal ID
Signal TransductionREACTOMER-HSA-162582
Signaling by GPCRREACTOMER-HSA-372790
GPCR ligand bindingREACTOMER-HSA-500792
Class A/1 (Rhodopsin-like receptors)REACTOMER-HSA-373076
Peptide ligand-binding receptorsREACTOMER-HSA-375276
Relaxin receptorsREACTOMER-HSA-444821
GPCR downstream signalingREACTOMER-HSA-388396
G alpha (i) signalling eventsREACTOMER-HSA-418594

Protein levels (Protein atlas)

Not detected
Low
Medium
High
cerebral cortex
cerebellum
hippocampus
caudate
thyroid gland
parathyroid gland
adrenal gland
nasopharynx
bronchus
lung
oral mucosa
salivary gland
esophagus
stomach 1
stomach 2
duodenum
small intestine
colon
rectum
liver
gallbladder
pancreas
kidney
urinary bladder
testis
epididymis
seminal vesicle
prostate
vagina
ovary
fallopian tube
endometrium 1
endometrium 2
cervix, uterine
placenta
breast
heart muscle
smooth muscle
skeletal muscle
soft tissue 1
soft tissue 2
adipose tissue
skin 1
skin 2
appendix
spleen
lymph node
tonsil
bone marrow

References

Pubmed IDYearTitleCitations
155256392005INSL5 is a high affinity specific agonist for GPCR142 (GPR100).32
250284982014Insulin-like peptide 5 is an orexigenic gastrointestinal hormone.28
208006032010Investigation of genetic susceptibility factors for human longevity - a targeted nonsynonymous SNP study.12
288573182017Liquid chromatography/mass spectrometry based detection and semi-quantitative analysis of INSL5 in human and murine tissues.11
231285692013INSL5 is a novel marker for human enteroendocrine cells of the large intestine and neuroendocrine tumours.10
191783842009Structure of human insulin-like peptide 5 and characterization of conserved hydrogen bonds and electrostatic interactions within the relaxin framework.8
234384392013INSL5 may be a unique marker of colorectal endocrine cells and neuroendocrine tumors.8
250439772014Identification of important residues of insulin-like peptide 5 and its receptor RXFP4 for ligand-receptor interactions.3
266610352016The C-terminus of the B-chain of human insulin-like peptide 5 is critical for cognate RXFP4 receptor activity.3
282746162017Interaction mechanism of insulin-like peptide 5 with relaxin family peptide receptor 4.2

Citation

Dessen P

INSL5 (insulin like 5)

Atlas Genet Cytogenet Oncol Haematol. 2013-11-01

Online version: http://atlasgeneticsoncology.org/gene/53569/insl5