INSR (insulin receptor)

2003-11-01  

Identity

HGNC
LOCATION
19p13.2
LOCUSID
ALIAS
CD220,HHF5
FUSION GENES

Other Information

Locus ID:

NCBI: 3643
MIM: 147670
HGNC: 6091
Ensembl: ENSG00000171105

Variants:

dbSNP: 3643
ClinVar: 3643
TCGA: ENSG00000171105
COSMIC: INSR

RNA/Proteins

Gene IDTranscript IDUniprot
ENSG00000171105ENST00000302850P06213
ENSG00000171105ENST00000341500P06213
ENSG00000171105ENST00000600492M0R3E6

Expression (GTEx)

0
10
20
30
40
50
60
70
80
90
100

Pathways

PathwaySourceExternal ID
mTOR signaling pathwayKEGGko04150
Adherens junctionKEGGko04520
Insulin signaling pathwayKEGGko04910
Type II diabetes mellitusKEGGko04930
mTOR signaling pathwayKEGGhsa04150
Adherens junctionKEGGhsa04520
Insulin signaling pathwayKEGGhsa04910
Type II diabetes mellitusKEGGhsa04930
Aldosterone-regulated sodium reabsorptionKEGGko04960
Aldosterone-regulated sodium reabsorptionKEGGhsa04960
PI3K-Akt signaling pathwayKEGGhsa04151
PI3K-Akt signaling pathwayKEGGko04151
HIF-1 signaling pathwayKEGGhsa04066
Ovarian steroidogenesisKEGGhsa04913
Ovarian steroidogenesisKEGGko04913
Non-alcoholic fatty liver disease (NAFLD)KEGGhsa04932
Non-alcoholic fatty liver disease (NAFLD)KEGGko04932
Ras signaling pathwayKEGGhsa04014
Rap1 signaling pathwayKEGGhsa04015
Rap1 signaling pathwayKEGGko04015
FoxO signaling pathwayKEGGhsa04068
cGMP-PKG signaling pathwayKEGGhsa04022
cGMP-PKG signaling pathwayKEGGko04022
AMPK signaling pathwayKEGGhsa04152
AMPK signaling pathwayKEGGko04152
PI3K-Akt signalingKEGGhsa_M00676
PI3K-Akt signalingKEGGM00676
Regulation of lipolysis in adipocytesKEGGhsa04923
Immune SystemREACTOMER-HSA-168256
Adaptive Immune SystemREACTOMER-HSA-1280218
Signaling by the B Cell Receptor (BCR)REACTOMER-HSA-983705
Downstream signaling events of B Cell Receptor (BCR)REACTOMER-HSA-1168372
PIP3 activates AKT signalingREACTOMER-HSA-1257604
Negative regulation of the PI3K/AKT networkREACTOMER-HSA-199418
Innate Immune SystemREACTOMER-HSA-168249
DAP12 interactionsREACTOMER-HSA-2172127
DAP12 signalingREACTOMER-HSA-2424491
Fc epsilon receptor (FCERI) signalingREACTOMER-HSA-2454202
Role of LAT2/NTAL/LAB on calcium mobilizationREACTOMER-HSA-2730905
Signal TransductionREACTOMER-HSA-162582
Signaling by EGFRREACTOMER-HSA-177929
GAB1 signalosomeREACTOMER-HSA-180292
Signaling by Insulin receptorREACTOMER-HSA-74752
Insulin receptor signalling cascadeREACTOMER-HSA-74751
IRS activationREACTOMER-HSA-74713
Signal attenuationREACTOMER-HSA-74749
Insulin receptor recyclingREACTOMER-HSA-77387
Signalling by NGFREACTOMER-HSA-166520
NGF signalling via TRKA from the plasma membraneREACTOMER-HSA-187037
PI3K/AKT activationREACTOMER-HSA-198203
Signaling by PDGFREACTOMER-HSA-186797
Downstream signal transductionREACTOMER-HSA-186763
Signaling by SCF-KITREACTOMER-HSA-1433557
Insulin resistanceKEGGhsa04931
Phospholipase D signaling pathwayKEGGko04072
Phospholipase D signaling pathwayKEGGhsa04072
Longevity regulating pathwayKEGGhsa04211
Longevity regulating pathway - multiple speciesKEGGko04213
Longevity regulating pathway - multiple speciesKEGGhsa04213
PI5P, PP2A and IER3 Regulate PI3K/AKT SignalingREACTOMER-HSA-6811558

Protein levels (Protein atlas)

Not detected
Low
Medium
High

PharmGKB

Entity IDNameTypeEvidenceAssociationPKPDPMIDs
PA128406956fluorouracilChemicalClinicalAnnotationassociatedPD
PA443560Breast NeoplasmsDiseaseClinicalAnnotationassociatedPD
PA445113NeutropeniaDiseaseClinicalAnnotationassociatedPD
PA449165cyclophosphamideChemicalClinicalAnnotationassociatedPD
PA449476epirubicinChemicalClinicalAnnotationassociatedPD
PA451728topiramateChemicalClinicalAnnotationassociatedPD26524290

References

Pubmed IDYearTitleCitations
121380942002Insulin/insulin-like growth factor I hybrid receptors have different biological characteristics depending on the insulin receptor isoform involved.125
178553432007Soluble Abeta inhibits specific signal transduction cascades common to the insulin receptor pathway.108
233028622013How insulin engages its primary binding site on the insulin receptor.96
199962722009BMS-754807, a small molecule inhibitor of insulin-like growth factor-1R/IR.88
199131212009Gene-centric association signals for lipids and apolipoproteins identified via the HumanCVD BeadChip.85
120319772002Plasma adiponectin concentration is associated with skeletal muscle insulin receptor tyrosine phosphorylation, and low plasma concentration precedes a decrease in whole-body insulin sensitivity in humans.82
169467082006Interaction of muscleblind, CUG-BP1 and hnRNP H proteins in DM1-associated aberrant IR splicing.77
127110072003Identification of a Vitamin D response element in the human insulin receptor gene promoter.72
145519162003Candidate gene association study in type 2 diabetes indicates a role for genes involved in beta-cell function as well as insulin action.71
187851792009Insulin receptor expression by human prostate cancers.68

Citation

Dessen P

INSR (insulin receptor)

Atlas Genet Cytogenet Oncol Haematol. 2003-11-01

Online version: http://atlasgeneticsoncology.org/gene/40986/insr