INSRR (insulin receptor related receptor)

2006-10-01  

Identity

HGNC
INSRR
LOCATION
1q23.1
LOCUSID
3645
ALIAS
IRR
FUSION GENES
Show Gene Fusions

Other Information

Locus ID:

NCBI: 3645
MIM: 147671
HGNC: 6093
Ensembl: ENSG00000027644

Variants:

dbSNP: 3645
ClinVar: 3645
TCGA: ENSG00000027644
COSMIC: INSRR

RNA/Proteins

Gene IDTranscript IDUniprot
ENSG00000027644ENST00000368195P14616

Expression (GTEx)

0
1
2
3
4
5
6
Adipose - Subcutaneous
Adipose - Visceral
Adrenal Gland
Artery - Aorta
Artery - Tibial
Bladder
Brain - Amygdala
Brain - Anterior cingulate cortex
Brain - Caudate
Brain - Cerebellar Hemisphere
Brain - Cerebellum
Brain - Cortex
Brain - Frontal Cortex
Brain - Hippocampus
Brain - Hypothalamus
Brain - Nucleus accumbens
Brain - Putamen
Brain - Spinal cord
Brain - Substantia nigra
Breast - Mammary Tissue
Cells - Cultured fibroblasts
Cells - EBV - transformed lymphocytes
Cervix - Ectocervix
Cervix - Endocervix
Colon - Sigmoid
Colon - Transverse
Esophagus - Gastroesophageal Junction
Esophagus - Mucosa
Esophagus - Muscularis
Fallopian Tube
Heart - Atrial Appendage
Heart - Left Ventricle
Kidney - Cortex
Kidney - Medulla
Liver
Lung
Minor Salivary Gland
Muscle - Skeletal
Nerve - Tibial
Ovary
Pancreas
Pituitary
Prostate
Skin - Not Sun Exposed
Skin - Sun Exposed
Small Intestine - Terminal Ileum
Spleen
Stomach
Testis
Thyroid
Uterus
Vagina
Whole Blood

Pathways

PathwaySourceExternal ID
Regulation of actin cytoskeletonKEGGko04810
Prostate cancerKEGGko05215
Regulation of actin cytoskeletonKEGGhsa04810
Prostate cancerKEGGhsa05215

Protein levels (Protein atlas)

Not detected
Low
Medium
High
N/A

References

Pubmed IDYearTitleCitations
207340642010A large-scale candidate gene association study of age at menarche and age at natural menopause.38
186604892008Multiple genetic variants along candidate pathways influence plasma high-density lipoprotein cholesterol concentrations.26
146545522003Coexpression of insulin receptor-related receptor and insulin-like growth factor 1 receptor correlates with enhanced apoptosis and dedifferentiation in human neuroblastomas.9
232204172013Insulin receptor-related receptor as an extracellular pH sensor involved in the regulation of acid-base balance.6
156291492005Comparative analysis of the signaling capabilities of the insulin receptor-related receptor.5
161954022006Expression of the insulin receptor-related receptor is induced by the preovulatory surge of luteinizing hormone in thecal-interstitial cells of the rat ovary.5
241215062013Structural determinants of the insulin receptor-related receptor activation by alkali.5
255974172015Mapping of alkali-sensing sites of the insulin receptor-related receptor. The role of L2 and fibronectin domains.4
238244602013Analysis of structural determinants of alkali sensor IRR positive cooperativity.1
291565932017Site-Directed Mutagenesis of the Fibronectin Domains in Insulin Receptor-Related Receptor.1

Citation

Dessen P

INSRR (insulin receptor related receptor)

Atlas Genet Cytogenet Oncol Haematol. 2006-10-01

Online version: http://atlasgeneticsoncology.org/gene/43325/insrr