INTS3 (integrator complex subunit 3)

2009-09-01  

Identity

HGNC
INTS3
LOCATION
1q21.3
LOCUSID
65123
ALIAS
C1orf193,C1orf60,INT3,SOSS-A,SOSSA
FUSION GENES
Show Gene Fusions

Other Information

Locus ID:

NCBI: 65123
MIM: 611347
HGNC: 26153
Ensembl: ENSG00000143624

Variants:

dbSNP: 65123
ClinVar: 65123
TCGA: ENSG00000143624
COSMIC: INTS3

RNA/Proteins

Gene IDTranscript IDUniprot
ENSG00000143624ENST00000318967Q68E01
ENSG00000143624ENST00000435409Q68E01
ENSG00000143624ENST00000476843A0A096LNW8
ENSG00000143624ENST00000503133H0Y8Z1
ENSG00000143624ENST00000512605Q68E01
ENSG00000143624ENST00000624515A0A096LPB9

Expression (GTEx)

0
50
100
150
Adipose - Subcutaneous
Adipose - Visceral
Adrenal Gland
Artery - Aorta
Artery - Tibial
Bladder
Brain - Amygdala
Brain - Anterior cingulate cortex
Brain - Caudate
Brain - Cerebellar Hemisphere
Brain - Cerebellum
Brain - Cortex
Brain - Frontal Cortex
Brain - Hippocampus
Brain - Hypothalamus
Brain - Nucleus accumbens
Brain - Putamen
Brain - Spinal cord
Brain - Substantia nigra
Breast - Mammary Tissue
Cells - Cultured fibroblasts
Cells - EBV - transformed lymphocytes
Cervix - Ectocervix
Cervix - Endocervix
Colon - Sigmoid
Colon - Transverse
Esophagus - Gastroesophageal Junction
Esophagus - Mucosa
Esophagus - Muscularis
Fallopian Tube
Heart - Atrial Appendage
Heart - Left Ventricle
Kidney - Cortex
Kidney - Medulla
Liver
Lung
Minor Salivary Gland
Muscle - Skeletal
Nerve - Tibial
Ovary
Pancreas
Pituitary
Prostate
Skin - Not Sun Exposed
Skin - Sun Exposed
Small Intestine - Terminal Ileum
Spleen
Stomach
Testis
Thyroid
Uterus
Vagina
Whole Blood

Pathways

PathwaySourceExternal ID
Gene ExpressionREACTOMER-HSA-74160
RNA polymerase II transcribes snRNA genesREACTOMER-HSA-6807505

Protein levels (Protein atlas)

Not detected
Low
Medium
High
cerebral cortex
cerebellum
hippocampus
caudate
thyroid gland
parathyroid gland
adrenal gland
nasopharynx
bronchus
lung
oral mucosa
salivary gland
esophagus
stomach 1
stomach 2
duodenum
small intestine
colon
rectum
liver
gallbladder
pancreas
kidney
urinary bladder
testis
epididymis
seminal vesicle
prostate
vagina
ovary
fallopian tube
endometrium 1
endometrium 2
cervix, uterine
placenta
breast
heart muscle
smooth muscle
skeletal muscle
soft tissue 1
soft tissue 2
adipose tissue
skin 1
skin 2
appendix
spleen
lymph node
tonsil
bone marrow

References

Pubmed IDYearTitleCitations
196835012009SOSS complexes participate in the maintenance of genomic stability.63
197865742009INTS3 controls the hSSB1-mediated DNA damage response.41
197590192009Integrator3, a partner of single-stranded DNA-binding protein 1, participates in the DNA damage response.17
239864772013A core hSSB1-INTS complex participates in the DNA damage response.16
291504352018Biochemical characterization of INTS3 and C9ORF80, two subunits of hNABP1/2 heterotrimeric complex in nucleic acid binding.3

Citation

Dessen P

INTS3 (integrator complex subunit 3)

Atlas Genet Cytogenet Oncol Haematol. 2009-09-01

Online version: http://atlasgeneticsoncology.org/gene/51127/ints3