IP6K1 (inositol hexakisphosphate kinase 1)

2007-04-01  

Identity

HGNC
LOCATION
3p21.31
LOCUSID
ALIAS
IHPK1,PiUS
FUSION GENES

Other Information

Locus ID:

NCBI: 9807
MIM: 606991
HGNC: 18360
Ensembl: ENSG00000176095

Variants:

dbSNP: 9807
ClinVar: 9807
TCGA: ENSG00000176095
COSMIC: IP6K1

RNA/Proteins

Gene IDTranscript IDUniprot
ENSG00000176095ENST00000321599Q92551
ENSG00000176095ENST00000321599A0A024R2X2
ENSG00000176095ENST00000395238Q92551
ENSG00000176095ENST00000460540Q92551
ENSG00000176095ENST00000468463C9JNA8
ENSG00000176095ENST00000613416Q92551
ENSG00000176095ENST00000613416A0A024R2X2

Expression (GTEx)

0
10
20
30
40
50
60
70
80
90

Pathways

PathwaySourceExternal ID
Phosphatidylinositol signaling systemKEGGko04070
Phosphatidylinositol signaling systemKEGGhsa04070
MetabolismREACTOMER-HSA-1430728
Inositol phosphate metabolismREACTOMER-HSA-1483249
Synthesis of IPs in the nucleusREACTOMER-HSA-1855191
Synthesis of pyrophosphates in the cytosolREACTOMER-HSA-1855167

Protein levels (Protein atlas)

Not detected
Low
Medium
High

References

Pubmed IDYearTitleCitations
192086222009Characterization of a selective inhibitor of inositol hexakisphosphate kinases: use in defining biological roles and metabolic relationships of inositol pyrophosphates.46
233227052013The regulation of runt-related transcription factor 2 by fibroblast growth factor-2 and connexin43 requires the inositol polyphosphate/protein kinase Cδ cascade.27
248651812014Discovery of InsP6-kinases as InsP6-dephosphorylating enzymes provides a new mechanism of cytosolic InsP6 degradation driven by the cellular ATP/ADP ratio.22
253494272014Inositol hexakisphosphate kinase-1 mediates assembly/disassembly of the CRL4-signalosome complex to regulate DNA repair and cell death.19
271406812016Deletion of inositol hexakisphosphate kinase 1 (IP6K1) reduces cell migration and invasion, conferring protection from aerodigestive tract carcinoma in mice.15
152216402004The IHPK1 gene is disrupted at the 3p21.31 breakpoint of t(3;9) in a family with type 2 diabetes mellitus.14
274744092016Inositol hexakisphosphate kinase 1 (IP6K1) activity is required for cytoplasmic dynein-driven transport.14
281541322017Neuronal migration is mediated by inositol hexakisphosphate kinase 1 via α-actinin and focal adhesion kinase.12
311863492019The inositol hexakisphosphate kinases IP6K1 and -2 regulate human cellular phosphate homeostasis, including XPR1-mediated phosphate export.6
203076172010Association analysis of 3p21 with Crohn's disease in a New Zealand population.2

Citation

Dessen P

IP6K1 (inositol hexakisphosphate kinase 1)

Atlas Genet Cytogenet Oncol Haematol. 2007-04-01

Online version: http://atlasgeneticsoncology.org/gene/47330/ip6k1