IP6K2 (inositol hexakisphosphate kinase 2)

2004-11-01  

Identity

HGNC
IP6K2
LOCATION
3p21.31
LOCUSID
51447
ALIAS
IHPK2,InsP6K2,PIUS
FUSION GENES
Show Gene Fusions

Other Information

Locus ID:

NCBI: 51447
MIM: 606992
HGNC: 17313
Ensembl: ENSG00000068745

Variants:

dbSNP: 51447
ClinVar: 51447
TCGA: ENSG00000068745
COSMIC: IP6K2

RNA/Proteins

Gene IDTranscript IDUniprot
ENSG00000068745ENST00000328631Q9UHH9
ENSG00000068745ENST00000328631B2RCP4
ENSG00000068745ENST00000340879Q9UHH9
ENSG00000068745ENST00000412795F8WDQ5
ENSG00000068745ENST00000412850C9JGK2
ENSG00000068745ENST00000413298Q9UHH9
ENSG00000068745ENST00000413654C9JLG7
ENSG00000068745ENST00000416707Q9UHH9
ENSG00000068745ENST00000417896C9JHV2
ENSG00000068745ENST00000424035C9J790
ENSG00000068745ENST00000431721Q9UHH9
ENSG00000068745ENST00000432678Q9UHH9
ENSG00000068745ENST00000433104C9JHV2
ENSG00000068745ENST00000434860C9JU99
ENSG00000068745ENST00000437427C9JHX0
ENSG00000068745ENST00000440424C9JU99
ENSG00000068745ENST00000443853C9JMC9
ENSG00000068745ENST00000443964C9J8W6
ENSG00000068745ENST00000446860Q9UHH9
ENSG00000068745ENST00000449563C9J536
ENSG00000068745ENST00000449610C9JHV2
ENSG00000068745ENST00000450045C9JRM0
ENSG00000068745ENST00000453202C9JHV2
ENSG00000068745ENST00000454335C9J124
ENSG00000068745ENST00000455545C9J3W9

Expression (GTEx)

0
10
20
30
40
50
60
70
80
90
100
Adipose - Subcutaneous
Adipose - Visceral
Adrenal Gland
Artery - Aorta
Artery - Tibial
Bladder
Brain - Amygdala
Brain - Anterior cingulate cortex
Brain - Caudate
Brain - Cerebellar Hemisphere
Brain - Cerebellum
Brain - Cortex
Brain - Frontal Cortex
Brain - Hippocampus
Brain - Hypothalamus
Brain - Nucleus accumbens
Brain - Putamen
Brain - Spinal cord
Brain - Substantia nigra
Breast - Mammary Tissue
Cells - Cultured fibroblasts
Cells - EBV - transformed lymphocytes
Cervix - Ectocervix
Cervix - Endocervix
Colon - Sigmoid
Colon - Transverse
Esophagus - Gastroesophageal Junction
Esophagus - Mucosa
Esophagus - Muscularis
Fallopian Tube
Heart - Atrial Appendage
Heart - Left Ventricle
Kidney - Cortex
Kidney - Medulla
Liver
Lung
Minor Salivary Gland
Muscle - Skeletal
Nerve - Tibial
Ovary
Pancreas
Pituitary
Prostate
Skin - Not Sun Exposed
Skin - Sun Exposed
Small Intestine - Terminal Ileum
Spleen
Stomach
Testis
Thyroid
Uterus
Vagina
Whole Blood

Pathways

PathwaySourceExternal ID
Phosphatidylinositol signaling systemKEGGko04070
Phosphatidylinositol signaling systemKEGGhsa04070
Immune SystemREACTOMER-HSA-168256
Cytokine Signaling in Immune systemREACTOMER-HSA-1280215
Interferon SignalingREACTOMER-HSA-913531
Interferon alpha/beta signalingREACTOMER-HSA-909733
MetabolismREACTOMER-HSA-1430728
Inositol phosphate metabolismREACTOMER-HSA-1483249
Synthesis of IPs in the nucleusREACTOMER-HSA-1855191

Protein levels (Protein atlas)

Not detected
Low
Medium
High
cerebral cortex
cerebellum
hippocampus
caudate
thyroid gland
adrenal gland
nasopharynx
bronchus
lung
oral mucosa
salivary gland
esophagus
stomach 1
stomach 2
duodenum
small intestine
colon
rectum
liver
gallbladder
pancreas
kidney
urinary bladder
testis
epididymis
seminal vesicle
prostate
vagina
ovary
fallopian tube
endometrium 1
endometrium 2
cervix, uterine
placenta
breast
heart muscle
smooth muscle
skeletal muscle
soft tissue 1
soft tissue 2
adipose tissue
skin 1
skin 2
appendix
spleen
tonsil
bone marrow

References

Pubmed IDYearTitleCitations
224469642012Genetics of gene expression in primary immune cells identifies cell type-specific master regulators and roles of HLA alleles.217
155339392005Inositol hexakisphosphate kinase-2, a physiologic mediator of cell death.51
210789642010p53-mediated apoptosis requires inositol hexakisphosphate kinase-2.36
233227052013The regulation of runt-related transcription factor 2 by fibroblast growth factor-2 and connexin43 requires the inositol polyphosphate/protein kinase Cδ cascade.27
118966212002Inositol hexakisphosphate kinase 2 sensitizes ovarian carcinoma cells to multiple cancer therapeutics.26
249569792014IP6K structure and the molecular determinants of catalytic specificity in an inositol phosphate kinase family.21
212628462011Casein kinase-2 mediates cell survival through phosphorylation and degradation of inositol hexakisphosphate kinase-2.17
173796002007Effect of inositol hexakisphosphate kinase 2 on transforming growth factor beta-activated kinase 1 and NF-kappaB activation.10
311863492019The inositol hexakisphosphate kinases IP6K1 and -2 regulate human cellular phosphate homeostasis, including XPR1-mediated phosphate export.6

Citation

Dessen P

IP6K2 (inositol hexakisphosphate kinase 2)

Atlas Genet Cytogenet Oncol Haematol. 2004-11-01

Online version: http://atlasgeneticsoncology.org/gene/42934/ip6k2