IPMK (inositol polyphosphate multikinase)

2016-10-01  

Identity

HGNC
LOCATION
10q21.1
LOCUSID
ALIAS
-
FUSION GENES

Other Information

Locus ID:

NCBI: 253430
MIM: 609851
HGNC: 20739
Ensembl: ENSG00000151151

Variants:

dbSNP: 253430
ClinVar: 253430
TCGA: ENSG00000151151
COSMIC: IPMK

RNA/Proteins

Gene IDTranscript IDUniprot
ENSG00000151151ENST00000373935Q8NFU5

Expression (GTEx)

0
1
2
3
4
5
6
7
8
9

Pathways

PathwaySourceExternal ID
Inositol phosphate metabolismKEGGko00562
Phosphatidylinositol signaling systemKEGGko04070
Inositol phosphate metabolismKEGGhsa00562
Phosphatidylinositol signaling systemKEGGhsa04070
Metabolic pathwaysKEGGhsa01100
Inositol phosphate metabolism, Ins(1,3,4)P3 => phytateKEGGM00132
MetabolismREACTOMER-HSA-1430728
Inositol phosphate metabolismREACTOMER-HSA-1483249
Synthesis of IPs in the nucleusREACTOMER-HSA-1855191
Inositol phosphate metabolism, Ins(1,3,4)P3 => phytateKEGGhsa_M00132

Protein levels (Protein atlas)

Not detected
Low
Medium
High

References

Pubmed IDYearTitleCitations
270886442016Association Between Genetic Traits for Immune-Mediated Diseases and Alzheimer Disease.46
227154672012Direct modification and activation of a nuclear receptor-PIP₂ complex by the inositol lipid kinase IPMK.45
233227052013The regulation of runt-related transcription factor 2 by fibroblast growth factor-2 and connexin43 requires the inositol polyphosphate/protein kinase Cδ cascade.27
235502112013Inositol polyphosphate multikinase is a coactivator of p53-mediated transcription and cell death.24
227186302012Nucleocytoplasmic shuttling of human inositol phosphate multikinase is influenced by CK2 phosphorylation.8
120278052002The human homologue of yeast ArgRIII protein is an inositol phosphate multikinase with predominantly nuclear localization.0
122234812002The human homolog of the rat inositol phosphate multikinase is an inositol 1,3,4,6-tetrakisphosphate 5-kinase.0
230509662012Inositol polyphosphate multikinase signaling in the regulation of metabolism.0
240749532013Human inositol polyphosphate multikinase regulates transcript-selective nuclear mRNA export to preserve genome integrity.0
246322082014Efficacious inhibition of Importin α/β-mediated nuclear import of human inositol phosphate multikinase.0

Citation

Dessen P

IPMK (inositol polyphosphate multikinase)

Atlas Genet Cytogenet Oncol Haematol. 2016-10-01

Online version: http://atlasgeneticsoncology.org/gene/56057/ipmk