IQGAP3 (IQ motif containing GTPase activating protein 3)

2014-08-01  

Identity

HGNC
IQGAP3
LOCATION
1q22
LOCUSID
128239
ALIAS
-
FUSION GENES
Show Gene Fusions

Other Information

Locus ID:

NCBI: 128239
HGNC: 20669
Ensembl: ENSG00000183856

Variants:

dbSNP: 128239
ClinVar: 128239
TCGA: ENSG00000183856
COSMIC: IQGAP3

RNA/Proteins

Gene IDTranscript IDUniprot
ENSG00000183856ENST00000361170Q86VI3
ENSG00000183856ENST00000491900F2Z2E2

Expression (GTEx)

0
5
10
15
20
Adipose - Subcutaneous
Adipose - Visceral
Adrenal Gland
Artery - Aorta
Artery - Tibial
Bladder
Brain - Amygdala
Brain - Anterior cingulate cortex
Brain - Caudate
Brain - Cerebellar Hemisphere
Brain - Cerebellum
Brain - Cortex
Brain - Frontal Cortex
Brain - Hippocampus
Brain - Hypothalamus
Brain - Nucleus accumbens
Brain - Putamen
Brain - Spinal cord
Brain - Substantia nigra
Breast - Mammary Tissue
Cells - Cultured fibroblasts
Cells - EBV - transformed lymphocytes
Cervix - Ectocervix
Cervix - Endocervix
Colon - Sigmoid
Colon - Transverse
Esophagus - Gastroesophageal Junction
Esophagus - Mucosa
Esophagus - Muscularis
Fallopian Tube
Heart - Atrial Appendage
Heart - Left Ventricle
Kidney - Cortex
Kidney - Medulla
Liver
Lung
Minor Salivary Gland
Muscle - Skeletal
Nerve - Tibial
Ovary
Pancreas
Pituitary
Prostate
Skin - Not Sun Exposed
Skin - Sun Exposed
Small Intestine - Terminal Ileum
Spleen
Stomach
Testis
Thyroid
Uterus
Vagina
Whole Blood

Pathways

PathwaySourceExternal ID
Regulation of actin cytoskeletonKEGGko04810
Regulation of actin cytoskeletonKEGGhsa04810
Signal TransductionREACTOMER-HSA-162582
Signaling by Rho GTPasesREACTOMER-HSA-194315
RHO GTPase EffectorsREACTOMER-HSA-195258
RHO GTPases activate IQGAPsREACTOMER-HSA-5626467

Protein levels (Protein atlas)

Not detected
Low
Medium
High
N/A

References

Pubmed IDYearTitleCitations
257222902015The biology of IQGAP proteins: beyond the cytoskeleton.45
248493192014IQGAP3 promotes EGFR-ERK signaling and the growth and metastasis of lung cancer cells.22
208006032010Investigation of genetic susceptibility factors for human longevity - a targeted nonsynonymous SNP study.12
212994992011IQ-motif selectivity in human IQGAP2 and IQGAP3: binding of calmodulin and myosin essential light chain.9
252293302014Involvement of IQGAP family proteins in the regulation of mammalian cell cytokinesis.9
290731992017Reduced expression of IQGAP2 and higher expression of IQGAP3 correlates with poor prognosis in cancers.7
288108752017Role of IQGAP3 in metastasis and epithelial-mesenchymal transition in human hepatocellular carcinoma.6
282819662016RNA Interference of IQ Motif Containing GTPase-Activating Protein 3 (IQGAP3) Inhibits Cell Proliferation and Invasion in Breast Carcinoma Cells.5
291310812018Overexpression of the Transmembrane Protein IQGAP3 Is Associated with Poor Survival of Patients with Gastric Cancer.1
315445702019High expression of IQGAP3 indicates poor prognosis in colorectal cancer patients.1

Citation

Dessen P

IQGAP3 (IQ motif containing GTPase activating protein 3)

Atlas Genet Cytogenet Oncol Haematol. 2014-08-01

Online version: http://atlasgeneticsoncology.org/gene/54383/iqgap3