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IREB2 (iron responsive element binding protein 2)

Identity

Alias_symbol (synonym)IRP2
Other aliasACO3
IRE-BP 2
IRE-BP2
IRP2AD
NDCAMA
HGNC (Hugo) IREB2
LocusID (NCBI) 3658
Atlas_Id 52239
Location 15q25.1  [Link to chromosome band 15q25]
Location_base_pair Starts at 78438176 and ends at 78501456 bp from pter ( according to hg38-Dec_2013)
Fusion genes
(updated 2017)		Data from Atlas, Mitelman, Cosmic Fusion, Fusion Cancer, TCGA fusion databases with official HUGO symbols (see references in chromosomal bands)
DAAM1 (14q23.1) / IREB2 (15q25.1)IREB2 (15q25.1) / LEO1 (15q21.2)IREB2 (15q25.1) / OXR1 (8q23.1)
RAPGEF2 (4q32.1) / IREB2 (15q25.1)RLF (1p34.2) / IREB2 (15q25.1)IREB2 15q25.1 / LEO1 15q21.2

Note

Non-annotated gene. Preliminary data : if you are an author
who wish to write a full paper/card on this gene, go to  How to contribute

DNA/RNA

 

Other Solid tumors implicated (Data extracted from papers in the Atlas) [ 1 ]
  t(15;15)(q21;q25) IREB2/LEO1

External links

Nomenclature
HGNC (Hugo)IREB2   6115
Cards
Entrez_Gene (NCBI)IREB2  3658  iron responsive element binding protein 2
AliasesACO3; IRE-BP; IRE-BP2; IRP2; 
IRP2AD; NDCAMA
GeneCards (Weizmann)IREB2
Ensembl hg19 (Hinxton)ENSG00000136381 [Gene_View]
Ensembl hg38 (Hinxton)ENSG00000136381 [Gene_View]  ENSG00000136381 [Sequence]  chr15:78438176-78501456 [Contig_View]  IREB2 [Vega]
ICGC DataPortalENSG00000136381
TCGA cBioPortalIREB2
AceView (NCBI)IREB2
Genatlas (Paris)IREB2
WikiGenes3658
SOURCE (Princeton)IREB2
Genetics Home Reference (NIH)IREB2
Genomic and cartography
GoldenPath hg38 (UCSC)IREB2  -     chr15:78438176-78501456 +  15q25.1   [Description]    (hg38-Dec_2013)
GoldenPath hg19 (UCSC)IREB2  -     15q25.1   [Description]    (hg19-Feb_2009)
GoldenPathIREB2 - 15q25.1 [CytoView hg19]  IREB2 - 15q25.1 [CytoView hg38]
ImmunoBaseENSG00000136381
Mapping of homologs : NCBIIREB2 [Mapview hg19]  IREB2 [Mapview hg38]
OMIM147582   618451   
Gene and transcription
Genbank (Entrez)AB209403 AB586699 AK027033 AK027034 AK292992
RefSeq transcript (Entrez)NM_001320941 NM_001320942 NM_001320943 NM_001354994 NM_004136
RefSeq genomic (Entrez)
Consensus coding sequences : CCDS (NCBI)IREB2
Cluster EST : UnigeneHs.436031 [ NCBI ]
CGAP (NCI)Hs.436031
Alternative Splicing GalleryENSG00000136381
Gene ExpressionIREB2 [ NCBI-GEO ]   IREB2 [ EBI - ARRAY_EXPRESS ]   IREB2 [ SEEK ]   IREB2 [ MEM ]
Gene Expression Viewer (FireBrowse)IREB2 [ Firebrowse - Broad ]
SOURCE (Princeton)Expression in : [Datasets]   [Normal Tissue Atlas]  [carcinoma Classsification]  [NCI60]
GenevestigatorExpression in : [tissues]  [cell-lines]  [cancer]  [perturbations]  
BioGPS (Tissue expression)3658
GTEX Portal (Tissue expression)IREB2
Human Protein AtlasENSG00000136381-IREB2 [pathology]   [cell]   [tissue]
Protein : pattern, domain, 3D structure
UniProt/SwissProtP48200   [function]  [subcellular_location]  [family_and_domains]  [pathology_and_biotech]  [ptm_processing]  [expression]  [interaction]
NextProtP48200  [Sequence]  [Exons]  [Medical]  [Publications]
With graphics : InterProP48200
Splice isoforms : SwissVarP48200
PhosPhoSitePlusP48200
Domaine pattern : Prosite (Expaxy)ACONITASE_1 (PS00450)    ACONITASE_2 (PS01244)   
Domains : Interpro (EBI)Acnase/IPM_dHydase_lsu_aba_1/3    Acoase/IPM_deHydtase_lsu_aba    Aconitase/3IPM_dehydase_swvl    Aconitase/IRP2    Aconitase_4Fe-4S_BS    Aconitase_4Fe-4S_dom    AconitaseA/IPMdHydase_ssu_swvl    IRE-BP2   
Domain families : Pfam (Sanger)Aconitase (PF00330)    Aconitase_C (PF00694)   
Domain families : Pfam (NCBI)pfam00330    pfam00694   
Conserved Domain (NCBI)IREB2
DMDM Disease mutations3658
Blocks (Seattle)IREB2
SuperfamilyP48200
Human Protein Atlas [tissue]ENSG00000136381-IREB2 [tissue]
Peptide AtlasP48200
HPRD08858
IPIIPI00008726   
Protein Interaction databases
DIP (DOE-UCLA)P48200
IntAct (EBI)P48200
FunCoupENSG00000136381
BioGRIDIREB2
STRING (EMBL)IREB2
ZODIACIREB2
Ontologies - Pathways
QuickGOP48200
Ontology : AmiGORNA binding  RNA binding  aconitate hydratase activity  protein binding  cytoplasm  mitochondrion  cytosol  cytosol  tricarboxylic acid cycle  citrate metabolic process  protoporphyrinogen IX biosynthetic process  iron ion transport  cellular iron ion homeostasis  post-embryonic development  negative regulation of translation  osteoclast differentiation  iron-responsive element binding  iron-responsive element binding  iron-responsive element binding  translation repressor activity  erythrocyte homeostasis  metal ion binding  intestinal absorption  4 iron, 4 sulfur cluster binding  
Ontology : EGO-EBIRNA binding  RNA binding  aconitate hydratase activity  protein binding  cytoplasm  mitochondrion  cytosol  cytosol  tricarboxylic acid cycle  citrate metabolic process  protoporphyrinogen IX biosynthetic process  iron ion transport  cellular iron ion homeostasis  post-embryonic development  negative regulation of translation  osteoclast differentiation  iron-responsive element binding  iron-responsive element binding  iron-responsive element binding  translation repressor activity  erythrocyte homeostasis  metal ion binding  intestinal absorption  4 iron, 4 sulfur cluster binding  
NDEx NetworkIREB2
Atlas of Cancer Signalling NetworkIREB2
Wikipedia pathwaysIREB2
Orthology - Evolution
OrthoDB3658
GeneTree (enSembl)ENSG00000136381
Phylogenetic Trees/Animal Genes : TreeFamIREB2
HOGENOMP48200
Homologs : HomoloGeneIREB2
Homology/Alignments : Family Browser (UCSC)IREB2
Gene fusions - Rearrangements
Fusion : MitelmanIREB2/LEO1 [15q25.1/15q21.2]  
Fusion PortalIREB2 15q25.1 LEO1 15q21.2 PRAD
Fusion : QuiverIREB2
Polymorphisms : SNP and Copy number variants
NCBI Variation ViewerIREB2 [hg38]
dbSNP Single Nucleotide Polymorphism (NCBI)IREB2
dbVarIREB2
ClinVarIREB2
1000_GenomesIREB2 
Exome Variant ServerIREB2
ExAC (Exome Aggregation Consortium)ENSG00000136381
GNOMAD BrowserENSG00000136381
Varsome BrowserIREB2
Genetic variants : HAPMAP3658
Genomic Variants (DGV)IREB2 [DGVbeta]
DECIPHERIREB2 [patients]   [syndromes]   [variants]   [genes]  
CONAN: Copy Number AnalysisIREB2 
Mutations
ICGC Data PortalIREB2 
TCGA Data PortalIREB2 
Broad Tumor PortalIREB2
OASIS PortalIREB2 [ Somatic mutations - Copy number]
Somatic Mutations in Cancer : COSMICIREB2  [overview]  [genome browser]  [tissue]  [distribution]  
Somatic Mutations in Cancer : COSMIC3DIREB2
Mutations and Diseases : HGMDIREB2
intOGen PortalIREB2
LOVD (Leiden Open Variation Database)Whole genome datasets
LOVD (Leiden Open Variation Database)LOVD - Leiden Open Variation Database
LOVD (Leiden Open Variation Database)LOVD 3.0 shared installation
LOVD (Leiden Open Variation Database)MSeqDR-LSDB Mitochondrial Disease Locus Specific Database
BioMutasearch IREB2
DgiDB (Drug Gene Interaction Database)IREB2
DoCM (Curated mutations)IREB2 (select the gene name)
CIViC (Clinical Interpretations of Variants in Cancer)IREB2 (select a term)
intoGenIREB2
Cancer3DIREB2(select the gene name)
Impact of mutations[PolyPhen2] [Provean] [Buck Institute : MutDB] [Mutation Assessor] [Mutanalyser]
Diseases
OMIM147582    618451   
Orphanet
DisGeNETIREB2
MedgenIREB2
Genetic Testing Registry IREB2
NextProtP48200 [Medical]
TSGene3658
GENETestsIREB2
Target ValidationIREB2
Huge Navigator IREB2 [HugePedia]
snp3D : Map Gene to Disease3658
BioCentury BCIQIREB2
ClinGenIREB2
Clinical trials, drugs, therapy
Chemical/Protein Interactions : CTD3658
Chemical/Pharm GKB GenePA29914
Clinical trialIREB2
Miscellaneous
canSAR (ICR)IREB2 (select the gene name)
DataMed IndexIREB2
Probes
Litterature
PubMed86 Pubmed reference(s) in Entrez
GeneRIFsGene References Into Functions (Entrez)
CoreMineIREB2
EVEXIREB2
GoPubMedIREB2
iHOPIREB2
Genes in titleautomatic search in PubMed
REVIEW articlesautomatic search in PubMed
Last year publicationsautomatic search in PubMed

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indexed on : Wed Nov 13 17:48:43 CET 2019
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