IRF2BP2 (interferon regulatory factor 2 binding protein 2)

2011-10-01  

Identity

HGNC
IRF2BP2
LOCATION
1q42.3
LOCUSID
359948
ALIAS
CVID14
FUSION GENES
Show Gene Fusions

Other Information

Locus ID:

NCBI: 359948
MIM: 615332
HGNC: 21729
Ensembl: ENSG00000168264

Variants:

dbSNP: 359948
ClinVar: 359948
TCGA: ENSG00000168264
COSMIC: IRF2BP2

RNA/Proteins

Gene IDTranscript IDUniprot
ENSG00000168264ENST00000366609Q7Z5L9
ENSG00000168264ENST00000366610Q7Z5L9

Expression (GTEx)

0
50
100
150
Adipose - Subcutaneous
Adipose - Visceral
Adrenal Gland
Artery - Aorta
Artery - Tibial
Bladder
Brain - Amygdala
Brain - Anterior cingulate cortex
Brain - Caudate
Brain - Cerebellar Hemisphere
Brain - Cerebellum
Brain - Cortex
Brain - Frontal Cortex
Brain - Hippocampus
Brain - Hypothalamus
Brain - Nucleus accumbens
Brain - Putamen
Brain - Spinal cord
Brain - Substantia nigra
Breast - Mammary Tissue
Cells - Cultured fibroblasts
Cells - EBV - transformed lymphocytes
Cervix - Ectocervix
Cervix - Endocervix
Colon - Sigmoid
Colon - Transverse
Esophagus - Gastroesophageal Junction
Esophagus - Mucosa
Esophagus - Muscularis
Fallopian Tube
Heart - Atrial Appendage
Heart - Left Ventricle
Kidney - Cortex
Kidney - Medulla
Liver
Lung
Minor Salivary Gland
Muscle - Skeletal
Nerve - Tibial
Ovary
Pancreas
Pituitary
Prostate
Skin - Not Sun Exposed
Skin - Sun Exposed
Small Intestine - Terminal Ileum
Spleen
Stomach
Testis
Thyroid
Uterus
Vagina
Whole Blood

Protein levels (Protein atlas)

Not detected
Low
Medium
High
cerebral cortex
cerebellum
hippocampus
caudate
thyroid gland
parathyroid gland
adrenal gland
nasopharynx
bronchus
lung
oral mucosa
salivary gland
esophagus
stomach 1
stomach 2
duodenum
small intestine
colon
rectum
liver
gallbladder
pancreas
kidney
urinary bladder
testis
epididymis
seminal vesicle
prostate
vagina
ovary
fallopian tube
endometrium 1
endometrium 2
cervix, uterine
placenta
breast
heart muscle
smooth muscle
skeletal muscle
soft tissue 1
soft tissue 2
adipose tissue
skin 1
skin 2
appendix
spleen
lymph node
tonsil
bone marrow

References

Pubmed IDYearTitleCitations
127994272003Identification of novel co-repressor molecules for Interferon Regulatory Factor-2.42
207027742010IRF2BP2 is a skeletal and cardiac muscle-enriched ischemia-inducible activator of VEGFA expression.28
207027742010IRF2BP2 is a skeletal and cardiac muscle-enriched ischemia-inducible activator of VEGFA expression.28
215763692011Interferon regulatory factor 2 binding protein 2 is a new NFAT1 partner and represses its transcriptional activity.21
231854132012Whole-transcriptome sequencing identifies novel IRF2BP2-CDX1 fusion gene brought about by translocation t(1;5)(q42;q32) in mesenchymal chondrosarcoma.19
265939742015Control of developmentally primed erythroid genes by combinatorial co-repressor actions.19
278724982017The cryptic IRF2BP2-RARA fusion transforms hematopoietic stem/progenitor cells and induces retinoid-sensitive acute promyelocytic leukemia.6
311860822019The IRF2BP2-KLF2 axis regulates osteoclast and osteoblast differentiation.1
191903362009Identification of a novel pathway that selectively modulates apoptosis of breast cancer cells.0
218873772011Identification of a phosphorylation-dependent nuclear localization motif in interferon regulatory factor 2 binding protein 2.0

Citation

Dessen P

IRF2BP2 (interferon regulatory factor 2 binding protein 2)

Atlas Genet Cytogenet Oncol Haematol. 2011-10-01

Online version: http://atlasgeneticsoncology.org/gene/52463/irf2bp2