IRF5 (interferon regulatory factor 5)

2003-05-01  

Identity

HGNC
IRF5
LOCATION
7q32.1
LOCUSID
3663
ALIAS
SLEB10

Other Information

Locus ID:

NCBI: 3663
MIM: 607218
HGNC: 6120
Ensembl: ENSG00000128604

Variants:

dbSNP: 3663
ClinVar: 3663
TCGA: ENSG00000128604
COSMIC: IRF5

RNA/Proteins

Gene IDTranscript IDUniprot
ENSG00000128604ENST00000249375Q13568
ENSG00000128604ENST00000357234Q13568
ENSG00000128604ENST00000357234C9JAU6
ENSG00000128604ENST00000402030Q13568
ENSG00000128604ENST00000464557C9JYP7
ENSG00000128604ENST00000465603Q13568
ENSG00000128604ENST00000467002C9JB67
ENSG00000128604ENST00000473745Q13568
ENSG00000128604ENST00000473787F8WDH6
ENSG00000128604ENST00000477535Q13568
ENSG00000128604ENST00000479582C9J7M2
ENSG00000128604ENST00000489702Q13568
ENSG00000128604ENST00000489702C9JAU6
ENSG00000128604ENST00000613821A0A087WWA0
ENSG00000128604ENST00000619830Q13568
ENSG00000128604ENST00000652525A0A0G2UM11

Expression (GTEx)

0
50
100
150
Adipose - Subcutaneous
Adipose - Visceral
Adrenal Gland
Artery - Aorta
Artery - Tibial
Bladder
Brain - Amygdala
Brain - Anterior cingulate cortex
Brain - Caudate
Brain - Cerebellar Hemisphere
Brain - Cerebellum
Brain - Cortex
Brain - Frontal Cortex
Brain - Hippocampus
Brain - Hypothalamus
Brain - Nucleus accumbens
Brain - Putamen
Brain - Spinal cord
Brain - Substantia nigra
Breast - Mammary Tissue
Cells - Cultured fibroblasts
Cells - EBV - transformed lymphocytes
Cervix - Ectocervix
Cervix - Endocervix
Colon - Sigmoid
Colon - Transverse
Esophagus - Gastroesophageal Junction
Esophagus - Mucosa
Esophagus - Muscularis
Fallopian Tube
Heart - Atrial Appendage
Heart - Left Ventricle
Kidney - Cortex
Kidney - Medulla
Liver
Lung
Minor Salivary Gland
Muscle - Skeletal
Nerve - Tibial
Ovary
Pancreas
Pituitary
Prostate
Skin - Not Sun Exposed
Skin - Sun Exposed
Small Intestine - Terminal Ileum
Spleen
Stomach
Testis
Thyroid
Uterus
Vagina
Whole Blood

Pathways

PathwaySourceExternal ID
Toll-like receptor signaling pathwayKEGGko04620
Toll-like receptor signaling pathwayKEGGhsa04620
Immune SystemREACTOMER-HSA-168256
Cytokine Signaling in Immune systemREACTOMER-HSA-1280215
Interferon SignalingREACTOMER-HSA-913531
Interferon alpha/beta signalingREACTOMER-HSA-909733
Interferon gamma signalingREACTOMER-HSA-877300

Protein levels (Protein atlas)

Not detected
Low
Medium
High
cerebral cortex
cerebellum
hippocampus
caudate
thyroid gland
parathyroid gland
adrenal gland
nasopharynx
lung
oral mucosa
salivary gland
esophagus
stomach 1
stomach 2
duodenum
small intestine
colon
rectum
liver
gallbladder
pancreas
kidney
urinary bladder
testis
epididymis
seminal vesicle
prostate
vagina
ovary
fallopian tube
endometrium 1
endometrium 2
cervix, uterine
placenta
breast
heart muscle
smooth muscle
skeletal muscle
soft tissue 1
soft tissue 2
adipose tissue
skin 1
skin 2
appendix
spleen
lymph node
tonsil
bone marrow

References

Pubmed IDYearTitleCitations
220250542011Transcriptional regulation of macrophage polarization: enabling diversity with identity.607
204538422010Genome-wide association study meta-analysis identifies seven new rheumatoid arthritis risk loci.480
198381932009Genome-wide association study in a Chinese Han population identifies nine new susceptibility loci for systemic lupus erythematosus.332
166420192006A common haplotype of interferon regulatory factor 5 (IRF5) regulates splicing and expression and is associated with increased risk of systemic lupus erythematosus.219
166420192006A common haplotype of interferon regulatory factor 5 (IRF5) regulates splicing and expression and is associated with increased risk of systemic lupus erythematosus.219
156578752005Polymorphisms in the tyrosine kinase 2 and interferon regulatory factor 5 genes are associated with systemic lupus erythematosus.182
156578752005Polymorphisms in the tyrosine kinase 2 and interferon regulatory factor 5 genes are associated with systemic lupus erythematosus.182
174128322007Three functional variants of IFN regulatory factor 5 (IRF5) define risk and protective haplotypes for human lupus.164
156958212005The interferon regulatory factor, IRF5, is a central mediator of toll-like receptor 7 signaling.133
186685682008Association of the IRF5 risk haplotype with high serum interferon-alpha activity in systemic lupus erythematosus patients.125

Citation

Dessen P

IRF5 (interferon regulatory factor 5)

Atlas Genet Cytogenet Oncol Haematol. 2003-05-01

Online version: http://atlasgeneticsoncology.org/gene/40992/irf5