Identity
HGNC
LOCATION
Xq22.3
LOCUSID
ALIAS
CHNG9,IRS-4,PY160
FUSION GENES
Non-annotated gene. Preliminary data : if you are an author who wish to write a full paper/card on this gene, contribute in submission tool
Other Information
Locus ID:
NCBI: 8471
MIM: 300904
HGNC: 6128
Ensembl: ENSG00000133124
Variants:
dbSNP: 8471
ClinVar: 8471
TCGA: ENSG00000133124
COSMIC: IRS4
RNA/Proteins
| Gene ID | Transcript ID | Uniprot |
|---|---|---|
| ENSG00000133124 | ENST00000372129 | O14654 |
Expression (GTEx)
Pathways
Protein levels (Protein atlas)
References
| Pubmed ID | Year | Title | Citations |
|---|---|---|---|
| 36860195 | 2023 | Further Delineation of Central Congenital Hypothyroidism due to Variants in TBL1X and IRS4. | 0 |
| 36860195 | 2023 | Further Delineation of Central Congenital Hypothyroidism due to Variants in TBL1X and IRS4. | 0 |
| 35550247 | 2022 | FER-mediated phosphorylation and PIK3R2 recruitment on IRS4 promotes AKT activation and tumorigenesis in ovarian cancer cells. | 7 |
| 35743985 | 2022 | Patients with Invasive Lobular Carcinoma Show a Significant Increase in IRS-4 Expression Compared to Infiltrative Ductal Carcinoma-A Histopathological Study. | 1 |
| 35550247 | 2022 | FER-mediated phosphorylation and PIK3R2 recruitment on IRS4 promotes AKT activation and tumorigenesis in ovarian cancer cells. | 7 |
| 35743985 | 2022 | Patients with Invasive Lobular Carcinoma Show a Significant Increase in IRS-4 Expression Compared to Infiltrative Ductal Carcinoma-A Histopathological Study. | 1 |
| 33894221 | 2021 | IRS4 promotes the progression of non-small cell lung cancer and confers resistance to EGFR-TKI through the activation of PI3K/Akt and Ras-MAPK pathways. | 10 |
| 34093435 | 2021 | Screening for Mutations in Isolated Central Hypothyroidism Reveals a Novel Mutation in Insulin Receptor Substrate 4. | 2 |
| 34590920 | 2021 | Chronic venous disease patients show increased IRS-4 expression in the great saphenous vein wall. | 5 |
| 33894221 | 2021 | IRS4 promotes the progression of non-small cell lung cancer and confers resistance to EGFR-TKI through the activation of PI3K/Akt and Ras-MAPK pathways. | 10 |
| 34093435 | 2021 | Screening for Mutations in Isolated Central Hypothyroidism Reveals a Novel Mutation in Insulin Receptor Substrate 4. | 2 |
| 34590920 | 2021 | Chronic venous disease patients show increased IRS-4 expression in the great saphenous vein wall. | 5 |
| 29185229 | 2018 | Overexpression of insulin receptor substrate-4 is correlated with clinical staging in colorectal cancer patients. | 8 |
| 30026872 | 2018 | Phosphorylation of IRS4 by CK1γ2 promotes its degradation by CHIP through the ubiquitin/lysosome pathway. | 11 |
| 30061370 | 2018 | Mutations in IRS4 are associated with central hypothyroidism. | 14 |
Citation
Dessen P
IRS4 (insulin receptor substrate 4)
Atlas Genet Cytogenet Oncol Haematol. 2007-02-01
Online version: http://atlasgeneticsoncology.org/gene/43671/irs4
