IRX4 (iroquois homeobox 4)

2012-09-01 Affiliation

Identity

HGNC

IRX4

LOCATION

5p15.33

LOCUSID

50805

ALIAS

IRXA3

FUSION GENES

Show Gene Fusions

Non-annotated gene. Preliminary data : if you are an author who wish to write a full paper/card on this gene, contribute in submission tool

Other Information

Locus ID:

NCBI: 50805
MIM: 606199
HGNC: 6129
Ensembl: ENSG00000113430

Variants:

dbSNP: 50805
ClinVar: 50805
TCGA: ENSG00000113430
COSMIC: IRX4

RNA/Proteins

Gene ID	Transcript ID	Uniprot
ENSG00000113430	ENST00000231357	P78413
ENSG00000113430	ENST00000505790	P78413
ENSG00000113430	ENST00000508261	D6RC00
ENSG00000113430	ENST00000511126	D6RAS8
ENSG00000113430	ENST00000513692	P78413
ENSG00000113430	ENST00000613726	P78413
ENSG00000113430	ENST00000622814	P78413

Expression (GTEx)

Adipose - Subcutaneous

Adipose - Visceral

Adrenal Gland

Artery - Aorta

Artery - Tibial

Bladder

Brain - Amygdala

Brain - Anterior cingulate cortex

Brain - Caudate

Brain - Cerebellar Hemisphere

Brain - Cerebellum

Brain - Cortex

Brain - Frontal Cortex

Brain - Hippocampus

Brain - Hypothalamus

Brain - Nucleus accumbens

Brain - Putamen

Brain - Spinal cord

Brain - Substantia nigra

Breast - Mammary Tissue

Cells - Cultured fibroblasts

Cells - EBV - transformed lymphocytes

Cervix - Ectocervix

Cervix - Endocervix

Colon - Sigmoid

Colon - Transverse

Esophagus - Gastroesophageal Junction

Esophagus - Mucosa

Esophagus - Muscularis

Fallopian Tube

Heart - Atrial Appendage

Heart - Left Ventricle

Kidney - Cortex

Kidney - Medulla

Liver

Lung

Minor Salivary Gland

Muscle - Skeletal

Nerve - Tibial

Ovary

Pancreas

Pituitary

Prostate

Skin - Not Sun Exposed

Skin - Sun Exposed

Small Intestine - Terminal Ileum

Spleen

Stomach

Testis

Thyroid

Uterus

Vagina

Whole Blood

References

Pubmed ID	Year	Title	Citations
19913121	2009	Gene-centric association signals for lipids and apolipoproteins identified via the HumanCVD BeadChip.	85
22323358	2012	IRX4 at 5p15 suppresses prostate cancer growth through the interaction with vitamin D receptor, conferring prostate cancer susceptibility.	17
20628086	2010	Variation at the NFATC2 locus increases the risk of thiazolidinedione-induced edema in the Diabetes REduction Assessment with ramipril and rosiglitazone Medication (DREAM) study.	11
24022300	2014	Variants at IRX4 as prostate cancer expression quantitative trait loci.	11
21544582	2011	Two novel mutations of the IRX4 gene in patients with congenital heart disease.	9
21779381	2011	Genetic determinants of cardiovascular events among women with migraine: a genome-wide association study.	4
18497553	2008	Genetic analysis of the Irx4 gene in hypertrophic cardiomyopathy.	1
18497553	2008	Genetic analysis of the Irx4 gene in hypertrophic cardiomyopathy.	1

Citation

Dessen P

IRX4 (iroquois homeobox 4)

Atlas Genet Cytogenet Oncol Haematol. 2012-09-01

Online version: http://atlasgeneticsoncology.org/gene/52873/irx4