ISG20 (interferon stimulated exonuclease gene 20)

2003-11-01  

Identity

HGNC
ISG20
LOCATION
15q26.1
LOCUSID
3669
ALIAS
CD25,HEM45
FUSION GENES
Show Gene Fusions

Other Information

Locus ID:

NCBI: 3669
MIM: 604533
HGNC: 6130
Ensembl: ENSG00000172183

Variants:

dbSNP: 3669
ClinVar: 3669
TCGA: ENSG00000172183
COSMIC: ISG20

RNA/Proteins

Gene IDTranscript IDUniprot
ENSG00000172183ENST00000306072Q96AZ6
ENSG00000172183ENST00000379224H3BLY5
ENSG00000172183ENST00000559876H0YMM4
ENSG00000172183ENST00000560741Q96AZ6

Expression (GTEx)

0
10
20
30
40
50
60
70
80
90
100
Adipose - Subcutaneous
Adipose - Visceral
Adrenal Gland
Artery - Aorta
Artery - Tibial
Bladder
Brain - Amygdala
Brain - Anterior cingulate cortex
Brain - Caudate
Brain - Cerebellar Hemisphere
Brain - Cerebellum
Brain - Cortex
Brain - Frontal Cortex
Brain - Hippocampus
Brain - Hypothalamus
Brain - Nucleus accumbens
Brain - Putamen
Brain - Spinal cord
Brain - Substantia nigra
Breast - Mammary Tissue
Cells - Cultured fibroblasts
Cells - EBV - transformed lymphocytes
Cervix - Ectocervix
Cervix - Endocervix
Colon - Sigmoid
Colon - Transverse
Esophagus - Gastroesophageal Junction
Esophagus - Mucosa
Esophagus - Muscularis
Fallopian Tube
Heart - Atrial Appendage
Heart - Left Ventricle
Kidney - Cortex
Kidney - Medulla
Liver
Lung
Minor Salivary Gland
Muscle - Skeletal
Nerve - Tibial
Ovary
Pancreas
Pituitary
Prostate
Skin - Not Sun Exposed
Skin - Sun Exposed
Small Intestine - Terminal Ileum
Spleen
Stomach
Testis
Thyroid
Uterus
Vagina
Whole Blood

Pathways

PathwaySourceExternal ID
Immune SystemREACTOMER-HSA-168256
Cytokine Signaling in Immune systemREACTOMER-HSA-1280215
Interferon SignalingREACTOMER-HSA-913531
Interferon alpha/beta signalingREACTOMER-HSA-909733

References

Pubmed IDYearTitleCitations
210363792011Antiviral activities of ISG20 in positive-strand RNA virus infections.33
155277702004Crystal structure of human ISG20, an interferon-induced antiviral ribonuclease.22
277640962016A Large Genome-Wide Association Study of Age-Related Hearing Impairment Using Electronic Health Records.19
273428132016Influenza A Virus-induced expression of ISG20 inhibits viral replication by interacting with nucleoprotein.14
276266892016Interferon-stimulated gene of 20 kDa protein (ISG20) degrades RNA of hepatitis B virus to impede the replication of HBV in vitro and in vivo.11
182784472008Cloning, eukaryotic expression of human ISG20 and preliminary study on the effect of its anti-HBV.8
291951262018Stimulation of Interferon-Stimulated Gene 20 by Thyroid Hormone Enhances Angiogenesis in Liver Cancer.6
298990852018Lnc-ISG20 Inhibits Influenza A Virus Replication by Enhancing ISG20 Expression.5
238300762013Death-domain associated protein-6 (DAXX) mediated apoptosis in hantavirus infection is counter-balanced by activation of interferon-stimulated nuclear transcription factors.2
285213752017A Genetic Marker Associated with Shoulder Dislocation.2

Citation

Dessen P

ISG20 (interferon stimulated exonuclease gene 20)

Atlas Genet Cytogenet Oncol Haematol. 2003-11-01

Online version: http://atlasgeneticsoncology.org/gene/40997/isg20