IST1 (IST1 factor associated with ESCRT-III)

2011-09-01  

Identity

HGNC
LOCATION
16q22.2
LOCUSID
ALIAS
CHMP8,OLC1
FUSION GENES

Other Information

Locus ID:

NCBI: 9798
MIM: 616434
HGNC: 28977
Ensembl: ENSG00000182149

Variants:

dbSNP: 9798
ClinVar: 9798
TCGA: ENSG00000182149
COSMIC: IST1

RNA/Proteins

Gene IDTranscript IDUniprot
ENSG00000182149ENST00000329908P53990
ENSG00000182149ENST00000378798P53990
ENSG00000182149ENST00000378799P53990
ENSG00000182149ENST00000424485F5GXM3
ENSG00000182149ENST00000439924E9PF00
ENSG00000182149ENST00000456820J3KR23
ENSG00000182149ENST00000534994H3BMU1
ENSG00000182149ENST00000535424P53990
ENSG00000182149ENST00000536027J3QQP8
ENSG00000182149ENST00000537613H3BUI0
ENSG00000182149ENST00000538104H3BQ38
ENSG00000182149ENST00000538850P53990
ENSG00000182149ENST00000539186H3BQF7
ENSG00000182149ENST00000540296H3BPP6
ENSG00000182149ENST00000541571P53990
ENSG00000182149ENST00000541918H3BUI0
ENSG00000182149ENST00000544564P53990
ENSG00000182149ENST00000568581H3BRE2
ENSG00000182149ENST00000606369P53990
ENSG00000182149ENST00000626438E9PF00

Expression (GTEx)

0
10
20
30
40
50
60
70
80
90

Pathways

PathwaySourceExternal ID
EndocytosisKEGGko04144
EndocytosisKEGGhsa04144
Immune SystemREACTOMER-HSA-168256
Innate Immune SystemREACTOMER-HSA-168249
Neutrophil degranulationREACTOMER-HSA-6798695

Protein levels (Protein atlas)

Not detected
Low
Medium
High

References

Pubmed IDYearTitleCitations
195259712009Structural basis for ESCRT-III protein autoinhibition.96
191294802009Essential role of hIST1 in cytokinesis.63
191294792009Biochemical analyses of human IST1 and its function in cytokinesis.57
238978882013An ESCRT-spastin interaction promotes fission of recycling tubules from the endosome.48
207199642010SPG20 protein spartin is recruited to midbodies by ESCRT-III protein Ist1 and participates in cytokinesis.30
260118582015ULK3 regulates cytokinetic abscission by phosphorylating ESCRT-III proteins.25
256570072015Distinct mechanisms of recognizing endosomal sorting complex required for transport III (ESCRT-III) protein IST1 by different microtubule interacting and trafficking (MIT) domains.16
301106332018Resolving ESCRT-III Spirals at the Intercellular Bridge of Dividing Cells Using 3D STORM.16
190015992008Overexpression of OLC1, cigarette smoke, and human lung tumorigenesis.11
208494182010Autolytic activity of human calpain 7 is enhanced by ESCRT-III-related protein IST1 through MIT-MIM interaction.11

Citation

Dessen P

IST1 (IST1 factor associated with ESCRT-III)

Atlas Genet Cytogenet Oncol Haematol. 2011-09-01

Online version: http://atlasgeneticsoncology.org/gene/52362/ist1