ITGAE (integrin subunit alpha E)

2003-11-01  

Identity

HGNC
LOCATION
17p13.2
LOCUSID
ALIAS
CD103,HUMINAE
FUSION GENES

Other Information

Locus ID:

NCBI: 3682
MIM: 604682
HGNC: 6147
Ensembl: ENSG00000083457

Variants:

dbSNP: 3682
ClinVar: 3682
TCGA: ENSG00000083457
COSMIC: ITGAE

RNA/Proteins

Gene IDTranscript IDUniprot
ENSG00000083457ENST00000263087P38570
ENSG00000083457ENST00000574026K7EQU0

Expression (GTEx)

0
5
10
15

Pathways

PathwaySourceExternal ID
Regulation of actin cytoskeletonKEGGko04810
Regulation of actin cytoskeletonKEGGhsa04810
Extracellular matrix organizationREACTOMER-HSA-1474244
Integrin cell surface interactionsREACTOMER-HSA-216083

Protein levels (Protein atlas)

Not detected
Low
Medium
High

References

Pubmed IDYearTitleCitations
162168862005Essential role for CD103 in the T cell-mediated regulation of experimental colitis.176
229228162012The molecular signature of tissue resident memory CD8 T cells isolated from the brain.123
241909782014Tumor-infiltrating lymphocytes expressing the tissue resident memory marker CD103 are associated with increased survival in high-grade serous ovarian cancer.108
217396712011Regional and mucosal memory T cells.105
173251972007Alpha E beta 7 integrin interaction with E-cadherin promotes antitumor CTL activity by triggering lytic granule polarization and exocytosis.77
219489822011Cutting edge: expression of XCR1 defines mouse lymphoid-tissue resident and migratory dendritic cells of the CD8α+ type.76
179751192008Association of gene variants with incident myocardial infarction in the Cardiovascular Health Study.65
203796142010Personalized smoking cessation: interactions between nicotine dose, dependence and quit-success genotype score.62
300065652018Co-expression of CD39 and CD103 identifies tumor-reactive CD8 T cells in human solid tumors.58
169209122006CD103 is a marker for alloantigen-induced regulatory CD8+ T cells.46

Citation

Dessen P

ITGAE (integrin subunit alpha E)

Atlas Genet Cytogenet Oncol Haematol. 2003-11-01

Online version: http://atlasgeneticsoncology.org/gene/41012/itgae