ITGAL (integrin subunit alpha L)

2003-08-01 Affiliation

Identity

HGNC

ITGAL

LOCATION

16p11.2

LOCUSID

3683

ALIAS

CD11A,LFA-1,LFA1A

FUSION GENES

Show Gene Fusions

Non-annotated gene. Preliminary data : if you are an author who wish to write a full paper/card on this gene, contribute in submission tool

Other Information

Locus ID:

NCBI: 3683
MIM: 153370
HGNC: 6148
Ensembl: ENSG00000005844

Variants:

dbSNP: 3683
ClinVar: 3683
TCGA: ENSG00000005844
COSMIC: ITGAL

RNA/Proteins

Gene ID	Transcript ID	Uniprot
ENSG00000005844	ENST00000356798	P20701
ENSG00000005844	ENST00000358164	P20701
ENSG00000005844	ENST00000433423	B4E021
ENSG00000005844	ENST00000562652	H3BS37
ENSG00000005844	ENST00000562857	B4DQ77
ENSG00000005844	ENST00000563615	I3L1D1
ENSG00000005844	ENST00000564118	H3BSV1
ENSG00000005844	ENST00000565864	H3BNL5
ENSG00000005844	ENST00000568926	H3BUT3
ENSG00000005844	ENST00000569725	I3L468

Expression (GTEx)

100

150

Adipose - Subcutaneous

Adipose - Visceral

Adrenal Gland

Artery - Aorta

Artery - Tibial

Bladder

Brain - Amygdala

Brain - Anterior cingulate cortex

Brain - Caudate

Brain - Cerebellar Hemisphere

Brain - Cerebellum

Brain - Cortex

Brain - Frontal Cortex

Brain - Hippocampus

Brain - Hypothalamus

Brain - Nucleus accumbens

Brain - Putamen

Brain - Spinal cord

Brain - Substantia nigra

Breast - Mammary Tissue

Cells - Cultured fibroblasts

Cells - EBV - transformed lymphocytes

Cervix - Ectocervix

Cervix - Endocervix

Colon - Sigmoid

Colon - Transverse

Esophagus - Gastroesophageal Junction

Esophagus - Mucosa

Esophagus - Muscularis

Fallopian Tube

Heart - Atrial Appendage

Heart - Left Ventricle

Kidney - Cortex

Kidney - Medulla

Liver

Lung

Minor Salivary Gland

Muscle - Skeletal

Nerve - Tibial

Ovary

Pancreas

Pituitary

Prostate

Skin - Not Sun Exposed

Skin - Sun Exposed

Small Intestine - Terminal Ileum

Spleen

Stomach

Testis

Thyroid

Uterus

Vagina

Whole Blood

Pathways

Pathway	Source	External ID
Cell adhesion molecules (CAMs)	KEGG	ko04514
Natural killer cell mediated cytotoxicity	KEGG	ko04650
Leukocyte transendothelial migration	KEGG	ko04670
Regulation of actin cytoskeleton	KEGG	ko04810
Cell adhesion molecules (CAMs)	KEGG	hsa04514
Natural killer cell mediated cytotoxicity	KEGG	hsa04650
Leukocyte transendothelial migration	KEGG	hsa04670
Regulation of actin cytoskeleton	KEGG	hsa04810
Viral myocarditis	KEGG	hsa05416
Malaria	KEGG	ko05144
Malaria	KEGG	hsa05144
Staphylococcus aureus infection	KEGG	ko05150
Staphylococcus aureus infection	KEGG	hsa05150
Rheumatoid arthritis	KEGG	ko05323
Rheumatoid arthritis	KEGG	hsa05323
HTLV-I infection	KEGG	ko05166
HTLV-I infection	KEGG	hsa05166
Epstein-Barr virus infection	KEGG	hsa05169
Epstein-Barr virus infection	KEGG	ko05169
Rap1 signaling pathway	KEGG	hsa04015
Rap1 signaling pathway	KEGG	ko04015
Immune System	REACTOME	R-HSA-168256
Adaptive Immune System	REACTOME	R-HSA-1280218
Immunoregulatory interactions between a Lymphoid and a non-Lymphoid cell	REACTOME	R-HSA-198933
Innate Immune System	REACTOME	R-HSA-168249
Hemostasis	REACTOME	R-HSA-109582
Cell surface interactions at the vascular wall	REACTOME	R-HSA-202733
Extracellular matrix organization	REACTOME	R-HSA-1474244
Integrin cell surface interactions	REACTOME	R-HSA-216083
Neutrophil degranulation	REACTOME	R-HSA-6798695

Protein levels (Protein atlas)

Not detected

Low

Medium

High

References

Pubmed ID	Year	Title	Citations
21597477	2011	The insider's guide to leukocyte integrin signalling and function.	165
20511548	2010	Mesenchymal stem cells inhibit human Th17 cell differentiation and function and induce a T regulatory cell phenotype.	155
15834409	2005	Lymphocyte arrest requires instantaneous induction of an extended LFA-1 conformation mediated by endothelium-bound chemokines.	120
17045822	2006	Activation of leukocyte beta2 integrins by conversion from bent to extended conformations.	102
15356110	2004	LFA-1 contributes an early signal for NK cell cytotoxicity.	101
17913807	2007	Adhesion molecule interactions facilitate human immunodeficiency virus type 1-induced virological synapse formation between T cells.	96
15611342	2004	The primacy of affinity over clustering in regulation of adhesiveness of the integrin {alpha}L{beta}2.	89
19268609	2009	Lymphocyte crawling and transendothelial migration require chemokine triggering of high-affinity LFA-1 integrin.	89
19913121	2009	Gene-centric association signals for lipids and apolipoproteins identified via the HumanCVD BeadChip.	85
15983060	2005	A talin-dependent LFA-1 focal zone is formed by rapidly migrating T lymphocytes.	71

Citation

Dessen P

ITGAL (integrin subunit alpha L)

Atlas Genet Cytogenet Oncol Haematol. 2003-08-01

Online version: http://atlasgeneticsoncology.org/gene/41013/itgal