ITGB3BP (integrin subunit beta 3 binding protein)

2007-02-01 Affiliation

Identity

HGNC

ITGB3BP

LOCATION

1p31.3

LOCUSID

23421

ALIAS

CENP-R,CENPR,HSU37139,NRIF3,TAP20

FUSION GENES

Show Gene Fusions

Non-annotated gene. Preliminary data : if you are an author who wish to write a full paper/card on this gene, contribute in submission tool

Other Information

Locus ID:

NCBI: 23421
MIM: 605494
HGNC: 6157
Ensembl: ENSG00000142856

Variants:

dbSNP: 23421
ClinVar: 23421
TCGA: ENSG00000142856
COSMIC: ITGB3BP

RNA/Proteins

Gene ID	Transcript ID	Uniprot
ENSG00000142856	ENST00000271002	Q13352
ENSG00000142856	ENST00000371092	Q13352
ENSG00000142856	ENST00000489099	Q13352

Expression (GTEx)

Adipose - Subcutaneous

Adipose - Visceral

Adrenal Gland

Artery - Aorta

Artery - Tibial

Bladder

Brain - Amygdala

Brain - Anterior cingulate cortex

Brain - Caudate

Brain - Cerebellar Hemisphere

Brain - Cerebellum

Brain - Cortex

Brain - Frontal Cortex

Brain - Hippocampus

Brain - Hypothalamus

Brain - Nucleus accumbens

Brain - Putamen

Brain - Spinal cord

Brain - Substantia nigra

Breast - Mammary Tissue

Cells - Cultured fibroblasts

Cells - EBV - transformed lymphocytes

Cervix - Ectocervix

Cervix - Endocervix

Colon - Sigmoid

Colon - Transverse

Esophagus - Gastroesophageal Junction

Esophagus - Mucosa

Esophagus - Muscularis

Fallopian Tube

Heart - Atrial Appendage

Heart - Left Ventricle

Kidney - Cortex

Kidney - Medulla

Liver

Lung

Minor Salivary Gland

Muscle - Skeletal

Nerve - Tibial

Ovary

Pancreas

Pituitary

Prostate

Skin - Not Sun Exposed

Skin - Sun Exposed

Small Intestine - Terminal Ileum

Spleen

Stomach

Testis

Thyroid

Uterus

Vagina

Whole Blood

Pathways

Pathway	Source	External ID
Signal Transduction	REACTOME	R-HSA-162582
Signalling by NGF	REACTOME	R-HSA-166520
p75 NTR receptor-mediated signalling	REACTOME	R-HSA-193704
Cell death signalling via NRAGE, NRIF and NADE	REACTOME	R-HSA-204998
NRIF signals cell death from the nucleus	REACTOME	R-HSA-205043
Signaling by Rho GTPases	REACTOME	R-HSA-194315
RHO GTPase Effectors	REACTOME	R-HSA-195258
RHO GTPases Activate Formins	REACTOME	R-HSA-5663220
Cell Cycle	REACTOME	R-HSA-1640170
Cell Cycle, Mitotic	REACTOME	R-HSA-69278
M Phase	REACTOME	R-HSA-68886
Mitotic Prometaphase	REACTOME	R-HSA-68877
Resolution of Sister Chromatid Cohesion	REACTOME	R-HSA-2500257
Mitotic Metaphase and Anaphase	REACTOME	R-HSA-2555396
Mitotic Anaphase	REACTOME	R-HSA-68882
Separation of Sister Chromatids	REACTOME	R-HSA-2467813
Chromosome Maintenance	REACTOME	R-HSA-73886
Nucleosome assembly	REACTOME	R-HSA-774815
Deposition of new CENPA-containing nucleosomes at the centromere	REACTOME	R-HSA-606279

Protein levels (Protein atlas)

Not detected

Low

Medium

High

References

Pubmed ID	Year	Title	Citations
20379614	2010	Personalized smoking cessation: interactions between nicotine dose, dependence and quit-success genotype score.	62
23028590	2012	Step-wise assembly, maturation and dynamic behavior of the human CENP-P/O/R/Q/U kinetochore sub-complex.	14
15254226	2004	Metastasis-associated protein 1 interacts with NRIF3, an estrogen-inducible nuclear receptor coregulator.	12
15082778	2004	The NRIF3 family of transcriptional coregulators induces rapid and profound apoptosis in breast cancer cells.	11
12244126	2002	Role of beta(3)-endonexin in the regulation of NF-kappaB-dependent expression of urokinase-type plasminogen activator receptor.	5
24386901	2014	The β3-integrin binding protein β3-endonexin is a novel negative regulator of hypoxia-inducible factor-1.	3
18521086	2008	Serine 28 phosphorylation of NRIF3 confers its co-activator function for estrogen receptor-alpha transactivation.	2
11864709	2002	Novel alternatively spliced form of beta(3)-endonexin.	0

Citation

Dessen P

ITGB3BP (integrin subunit beta 3 binding protein)

Atlas Genet Cytogenet Oncol Haematol. 2007-02-01

Online version: http://atlasgeneticsoncology.org/gene/45622/itgb3bp