IVNS1ABP (influenza virus NS1A binding protein)

2016-01-01  

Identity

HGNC
IVNS1ABP
LOCATION
1q25.3
LOCUSID
10625
ALIAS
ARA3,FLARA3,HSPC068,IMD70,KLHL39,ND1,NS-1,NS1-BP,NS1BP
FUSION GENES
Show Gene Fusions

Other Information

Locus ID:

NCBI: 10625
MIM: 609209
HGNC: 16951
Ensembl: ENSG00000116679

Variants:

dbSNP: 10625
ClinVar: 10625
TCGA: ENSG00000116679
COSMIC: IVNS1ABP

RNA/Proteins

Gene IDTranscript IDUniprot
ENSG00000116679ENST00000367497X6R674
ENSG00000116679ENST00000367498Q9Y6Y0
ENSG00000116679ENST00000422754H0Y5Y2

Expression (GTEx)

0
50
100
150
Adipose - Subcutaneous
Adipose - Visceral
Adrenal Gland
Artery - Aorta
Artery - Tibial
Bladder
Brain - Amygdala
Brain - Anterior cingulate cortex
Brain - Caudate
Brain - Cerebellar Hemisphere
Brain - Cerebellum
Brain - Cortex
Brain - Frontal Cortex
Brain - Hippocampus
Brain - Hypothalamus
Brain - Nucleus accumbens
Brain - Putamen
Brain - Spinal cord
Brain - Substantia nigra
Breast - Mammary Tissue
Cells - Cultured fibroblasts
Cells - EBV - transformed lymphocytes
Cervix - Ectocervix
Cervix - Endocervix
Colon - Sigmoid
Colon - Transverse
Esophagus - Gastroesophageal Junction
Esophagus - Mucosa
Esophagus - Muscularis
Fallopian Tube
Heart - Atrial Appendage
Heart - Left Ventricle
Kidney - Cortex
Kidney - Medulla
Liver
Lung
Minor Salivary Gland
Muscle - Skeletal
Nerve - Tibial
Ovary
Pancreas
Pituitary
Prostate
Skin - Not Sun Exposed
Skin - Sun Exposed
Small Intestine - Terminal Ileum
Spleen
Stomach
Testis
Thyroid
Uterus
Vagina
Whole Blood

Pathways

PathwaySourceExternal ID
Influenza AKEGGko05164
Influenza AKEGGhsa05164

Protein levels (Protein atlas)

Not detected
Low
Medium
High
cerebral cortex
cerebellum
hippocampus
caudate
thyroid gland
adrenal gland
nasopharynx
bronchus
lung
oral mucosa
salivary gland
esophagus
stomach 1
stomach 2
duodenum
small intestine
colon
rectum
liver
gallbladder
pancreas
kidney
testis
epididymis
seminal vesicle
prostate
vagina
ovary
fallopian tube
endometrium 1
endometrium 2
cervix, uterine
placenta
breast
heart muscle
smooth muscle
skeletal muscle
soft tissue 1
soft tissue 2
adipose tissue
skin 1
skin 2
appendix
spleen
lymph node
tonsil
bone marrow

References

Pubmed IDYearTitleCitations
203796142010Personalized smoking cessation: interactions between nicotine dose, dependence and quit-success genotype score.62
205322022010Use of genome-wide expression data to mine the "Gray Zone" of GWA studies leads to novel candidate obesity genes.34
238259512013Cellular RNA binding proteins NS1-BP and hnRNP K regulate influenza A virus RNA splicing.34
179963132007The kelch protein NS1-BP interacts with alpha-enolase/MBP-1 and is involved in c-Myc gene transcriptional control.21
256198342015KLHL39 suppresses colon cancer metastasis by blocking KLHL20-mediated PML and DAPK ubiquitination.11
299218782018Co-regulatory activity of hnRNP K and NS1-BP in influenza and human mRNA splicing.10
242101022013Expression of non-structural-1A binding protein in lung epithelial cells is modulated by miRNA-548an on exposure to influenza A virus.9
298716742018NS1-binding protein radiosensitizes esophageal squamous cell carcinoma by transcriptionally suppressing c-Myc.4
305382012018Structural-functional interactions of NS1-BP protein with the splicing and mRNA export machineries for viral and host gene expression.2
294970222018Crystal structure of the Kelch domain of human NS1-binding protein at 1.98 Å resolution.0

Citation

Dessen P

IVNS1ABP (influenza virus NS1A binding protein)

Atlas Genet Cytogenet Oncol Haematol. 2016-01-01

Online version: http://atlasgeneticsoncology.org/gene/55603/ivns1abp