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JAM3 (junctional adhesion molecule 3)

Identity

Alias (NCBI)JAM-2
JAM-3
JAM-C
JAMC
HGNC (Hugo) JAM3
HGNC Alias symbJAM-C
JAMC
LocusID (NCBI) 83700
Atlas_Id 45647
Location 11q25  [Link to chromosome band 11q25]
Location_base_pair Starts at 134069072 and ends at 134152000 bp from pter ( according to hg38-Dec_2013)
Fusion genes
(updated 2017)
Data from Atlas, Mitelman, Cosmic Fusion, Fusion Cancer, TCGA fusion databases with official HUGO symbols (see references in chromosomal bands)
JAM3 (11q25) / EPS8L2 (11p15.5)JAM3 (11q25) / JAM3 (11q25)

Note

Non-annotated gene. Preliminary data : if you are an author
who wish to write a full paper/card on this gene, go to  How to contribute

DNA/RNA

 



External links

Nomenclature
HGNC (Hugo)JAM3   15532
Cards
Entrez_Gene (NCBI)JAM3    junctional adhesion molecule 3
AliasesJAM-2; JAM-3; JAM-C; JAMC
GeneCards (Weizmann)JAM3
Ensembl hg19 (Hinxton)ENSG00000166086 [Gene_View]
Ensembl hg38 (Hinxton)ENSG00000166086 [Gene_View]  ENSG00000166086 [Sequence]  chr11:134069072-134152000 [Contig_View]  JAM3 [Vega]
ICGC DataPortalENSG00000166086
TCGA cBioPortalJAM3
AceView (NCBI)JAM3
Genatlas (Paris)JAM3
SOURCE (Princeton)JAM3
Genetics Home Reference (NIH)JAM3
Genomic and cartography
GoldenPath hg38 (UCSC)JAM3  -     chr11:134069072-134152000 +  11q25   [Description]    (hg38-Dec_2013)
GoldenPath hg19 (UCSC)JAM3  -     11q25   [Description]    (hg19-Feb_2009)
GoldenPathJAM3 - 11q25 [CytoView hg19]  JAM3 - 11q25 [CytoView hg38]
ImmunoBaseENSG00000166086
genome Data Viewer NCBIJAM3 [Mapview hg19]  
OMIM606871   613730   
Gene and transcription
Genbank (Entrez)AF356518 AF448478 AJ344431 AJ416101 AK027435
RefSeq transcript (Entrez)NM_001205329 NM_032801
RefSeq genomic (Entrez)
Consensus coding sequences : CCDS (NCBI)JAM3
Alternative Splicing GalleryENSG00000166086
Gene ExpressionJAM3 [ NCBI-GEO ]   JAM3 [ EBI - ARRAY_EXPRESS ]   JAM3 [ SEEK ]   JAM3 [ MEM ]
Gene Expression Viewer (FireBrowse)JAM3 [ Firebrowse - Broad ]
GenevisibleExpression of JAM3 in : [tissues]  [cell-lines]  [cancer]  [perturbations]  
BioGPS (Tissue expression)83700
GTEX Portal (Tissue expression)JAM3
Human Protein AtlasENSG00000166086-JAM3 [pathology]   [cell]   [tissue]
Protein : pattern, domain, 3D structure
UniProt/SwissProtQ9BX67   [function]  [subcellular_location]  [family_and_domains]  [pathology_and_biotech]  [ptm_processing]  [expression]  [interaction]
NextProtQ9BX67  [Sequence]  [Exons]  [Medical]  [Publications]
With graphics : InterProQ9BX67
Splice isoforms : SwissVarQ9BX67
PhosPhoSitePlusQ9BX67
Domaine pattern : Prosite (Expaxy)IG_LIKE (PS50835)   
Domains : Interpro (EBI)Ig-like_dom    Ig-like_dom_sf    Ig-like_fold    Ig_sub    Ig_sub2    Ig_V-set    JAM-C   
Domain families : Pfam (Sanger)V-set (PF07686)   
Domain families : Pfam (NCBI)pfam07686   
Domain families : Smart (EMBL)IG (SM00409)  IGc2 (SM00408)  IGv (SM00406)  
Conserved Domain (NCBI)JAM3
Blocks (Seattle)JAM3
SuperfamilyQ9BX67
Human Protein Atlas [tissue]ENSG00000166086-JAM3 [tissue]
Peptide AtlasQ9BX67
HPRD06042
IPIIPI00902570   IPI00152850   IPI00985372   IPI00983157   IPI00985112   IPI00983247   
Protein Interaction databases
DIP (DOE-UCLA)Q9BX67
IntAct (EBI)Q9BX67
BioGRIDJAM3
STRING (EMBL)JAM3
ZODIACJAM3
Ontologies - Pathways
QuickGOQ9BX67
Ontology : AmiGOangiogenesis  neutrophil homeostasis  adaptive immune response  myeloid progenitor cell differentiation  leukocyte migration involved in inflammatory response  positive regulation of cellular extravasation  integrin binding  protein binding  extracellular space  Golgi apparatus  plasma membrane  plasma membrane  integral component of plasma membrane  microvillus  cell-cell junction  bicellular tight junction  cell-matrix adhesion  spermatid development  transmission of nerve impulse  establishment of cell polarity  desmosome  extracellular matrix organization  axon regeneration  filamentous actin  paranodal junction  negative regulation of integrin activation  negative regulation of cell adhesion mediated by integrin  heterotypic cell-cell adhesion  adherens junction assembly  protein localization to cell surface  maintenance of blood-brain barrier  myelination  protein homodimerization activity  Schmidt-Lanterman incisure  cell-cell contact zone  apical protein localization  protein heterodimerization activity  leukocyte migration  tight junction  regulation of neutrophil chemotaxis  regulation of actin cytoskeleton organization by cell-cell adhesion  hematopoietic stem cell migration to bone marrow  granulocyte migration  cell-cell adhesion  cell-cell adhesion  cell-cell adhesion mediator activity  protein complex involved in cell adhesion  protein localization to cell junction  positive regulation of membrane permeability  
Ontology : EGO-EBIangiogenesis  neutrophil homeostasis  adaptive immune response  myeloid progenitor cell differentiation  leukocyte migration involved in inflammatory response  positive regulation of cellular extravasation  integrin binding  protein binding  extracellular space  Golgi apparatus  plasma membrane  plasma membrane  integral component of plasma membrane  microvillus  cell-cell junction  bicellular tight junction  cell-matrix adhesion  spermatid development  transmission of nerve impulse  establishment of cell polarity  desmosome  extracellular matrix organization  axon regeneration  filamentous actin  paranodal junction  negative regulation of integrin activation  negative regulation of cell adhesion mediated by integrin  heterotypic cell-cell adhesion  adherens junction assembly  protein localization to cell surface  maintenance of blood-brain barrier  myelination  protein homodimerization activity  Schmidt-Lanterman incisure  cell-cell contact zone  apical protein localization  protein heterodimerization activity  leukocyte migration  tight junction  regulation of neutrophil chemotaxis  regulation of actin cytoskeleton organization by cell-cell adhesion  hematopoietic stem cell migration to bone marrow  granulocyte migration  cell-cell adhesion  cell-cell adhesion  cell-cell adhesion mediator activity  protein complex involved in cell adhesion  protein localization to cell junction  positive regulation of membrane permeability  
Pathways : KEGGCell adhesion molecules (CAMs)    Tight junction    Leukocyte transendothelial migration    Epithelial cell signaling in Helicobacter pylori infection   
NDEx NetworkJAM3
Atlas of Cancer Signalling NetworkJAM3
Wikipedia pathwaysJAM3
Orthology - Evolution
OrthoDB83700
GeneTree (enSembl)ENSG00000166086
Phylogenetic Trees/Animal Genes : TreeFamJAM3
HOGENOMQ9BX67
Homologs : HomoloGeneJAM3
Homology/Alignments : Family Browser (UCSC)JAM3
Gene fusions - Rearrangements
Fusion : QuiverJAM3
Polymorphisms : SNP and Copy number variants
NCBI Variation ViewerJAM3 [hg38]
dbVarJAM3
ClinVarJAM3
MonarchJAM3
1000_GenomesJAM3 
Exome Variant ServerJAM3
GNOMAD BrowserENSG00000166086
Varsome BrowserJAM3
Genomic Variants (DGV)JAM3 [DGVbeta]
DECIPHERJAM3 [patients]   [syndromes]   [variants]   [genes]  
CONAN: Copy Number AnalysisJAM3 
Mutations
ICGC Data PortalJAM3 
TCGA Data PortalJAM3 
Broad Tumor PortalJAM3
OASIS PortalJAM3 [ Somatic mutations - Copy number]
Somatic Mutations in Cancer : COSMICJAM3  [overview]  [genome browser]  [tissue]  [distribution]  
Somatic Mutations in Cancer : COSMIC3DJAM3
Mutations and Diseases : HGMDJAM3
LOVD (Leiden Open Variation Database)Whole genome datasets
LOVD (Leiden Open Variation Database)LOVD 3.0 shared installation
BioMutasearch JAM3
DgiDB (Drug Gene Interaction Database)JAM3
DoCM (Curated mutations)JAM3 (select the gene name)
CIViC (Clinical Interpretations of Variants in Cancer)JAM3 (select a term)
intoGenJAM3
Cancer3DJAM3(select the gene name)
Impact of mutations[PolyPhen2] [Provean] [Buck Institute : MutDB] [Mutation Assessor] [Mutanalyser]
Diseases
OMIM606871    613730   
Orphanet21229   
DisGeNETJAM3
MedgenJAM3
Genetic Testing Registry JAM3
NextProtQ9BX67 [Medical]
GENETestsJAM3
Target ValidationJAM3
Huge Navigator JAM3 [HugePedia]
ClinGenJAM3 (curated)
Clinical trials, drugs, therapy
MyCancerGenomeJAM3
Protein Interactions : CTD
Pharm GKB GenePA29993
PharosQ9BX67
Clinical trialJAM3
Miscellaneous
canSAR (ICR)JAM3 (select the gene name)
HarmonizomeJAM3
DataMed IndexJAM3
Probes
Litterature
PubMed74 Pubmed reference(s) in Entrez
GeneRIFsGene References Into Functions (Entrez)
EVEXJAM3
Genes in titleautomatic search in PubMed
REVIEW articlesautomatic search in PubMed
Last year publicationsautomatic search in PubMed

Search in all EBI   NCBI

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indexed on : Thu Mar 25 19:27:18 CET 2021

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