JAM3 (junctional adhesion molecule 3)

2007-02-01  

Identity

HGNC
JAM3
LOCATION
11q25
LOCUSID
83700
ALIAS
JAM-2,JAM-3,JAM-C,JAMC
FUSION GENES
Show Gene Fusions

Other Information

Locus ID:

NCBI: 83700
MIM: 606871
HGNC: 15532
Ensembl: ENSG00000166086

Variants:

dbSNP: 83700
ClinVar: 83700
TCGA: ENSG00000166086
COSMIC: JAM3

RNA/Proteins

Gene IDTranscript IDUniprot
ENSG00000166086ENST00000299106Q9BX67
ENSG00000166086ENST00000441717Q9BX67
ENSG00000166086ENST00000532252H0YCW9
ENSG00000166086ENST00000534549H0YD98

Expression (GTEx)

0
50
100
150
Adipose - Subcutaneous
Adipose - Visceral
Adrenal Gland
Artery - Aorta
Artery - Tibial
Bladder
Brain - Amygdala
Brain - Anterior cingulate cortex
Brain - Caudate
Brain - Cerebellar Hemisphere
Brain - Cerebellum
Brain - Cortex
Brain - Frontal Cortex
Brain - Hippocampus
Brain - Hypothalamus
Brain - Nucleus accumbens
Brain - Putamen
Brain - Spinal cord
Brain - Substantia nigra
Breast - Mammary Tissue
Cells - Cultured fibroblasts
Cells - EBV - transformed lymphocytes
Cervix - Ectocervix
Cervix - Endocervix
Colon - Sigmoid
Colon - Transverse
Esophagus - Gastroesophageal Junction
Esophagus - Mucosa
Esophagus - Muscularis
Fallopian Tube
Heart - Atrial Appendage
Heart - Left Ventricle
Kidney - Cortex
Kidney - Medulla
Liver
Lung
Minor Salivary Gland
Muscle - Skeletal
Nerve - Tibial
Ovary
Pancreas
Pituitary
Prostate
Skin - Not Sun Exposed
Skin - Sun Exposed
Small Intestine - Terminal Ileum
Spleen
Stomach
Testis
Thyroid
Uterus
Vagina
Whole Blood

Pathways

PathwaySourceExternal ID
Cell adhesion molecules (CAMs)KEGGko04514
Tight junctionKEGGko04530
Leukocyte transendothelial migrationKEGGko04670
Epithelial cell signaling in Helicobacter pylori infectionKEGGko05120
Cell adhesion molecules (CAMs)KEGGhsa04514
Tight junctionKEGGhsa04530
Leukocyte transendothelial migrationKEGGhsa04670
Epithelial cell signaling in Helicobacter pylori infectionKEGGhsa05120
HemostasisREACTOMER-HSA-109582
Cell surface interactions at the vascular wallREACTOMER-HSA-202733
Extracellular matrix organizationREACTOMER-HSA-1474244
Integrin cell surface interactionsREACTOMER-HSA-216083

Protein levels (Protein atlas)

Not detected
Low
Medium
High
cerebral cortex
cerebellum
hippocampus
caudate
thyroid gland
parathyroid gland
adrenal gland
nasopharynx
bronchus
lung
oral mucosa
salivary gland
esophagus
stomach 1
stomach 2
duodenum
small intestine
colon
rectum
liver
gallbladder
pancreas
kidney
urinary bladder
testis
epididymis
seminal vesicle
prostate
vagina
ovary
fallopian tube
endometrium 1
endometrium 2
cervix, uterine
placenta
breast
heart muscle
smooth muscle
skeletal muscle
soft tissue 1
soft tissue 2
adipose tissue
skin 1
skin 2
appendix
spleen
lymph node
tonsil
bone marrow

References

Pubmed IDYearTitleCitations
122088822002The junctional adhesion molecule 3 (JAM-3) on human platelets is a counterreceptor for the leukocyte integrin Mac-1.102
199131212009Gene-centric association signals for lipids and apolipoproteins identified via the HumanCVD BeadChip.85
154858322004The junctional adhesion molecule-C promotes neutrophil transendothelial migration in vitro and in vivo.69
171167312006Junctional adhesion molecule-C regulates vascular endothelial permeability by modulating VE-cadherin-mediated cell-cell contacts.61
176250652007JAM-C regulates unidirectional monocyte transendothelial migration in inflammation.53
158791422005Junctional adhesion molecule-C regulates the early influx of leukocytes into tissues during inflammation.48
115901462001Cloning of human junctional adhesion molecule 3 (JAM3) and its identification as the JAM2 counter-receptor.47
217966282012A four-gene methylation marker panel as triage test in high-risk human papillomavirus positive patients.42
151948132004JAM-C is a component of desmosomes and a ligand for CD11b/CD18-mediated neutrophil transepithelial migration.39
120701352002JAM2 interacts with alpha4beta1. Facilitation by JAM3.38

Citation

Dessen P

JAM3 (junctional adhesion molecule 3)

Atlas Genet Cytogenet Oncol Haematol. 2007-02-01

Online version: http://atlasgeneticsoncology.org/gene/45647/jam3