JMJD6 (jumonji domain containing 6, arginine demethylase and lysine hydroxylase)

2013-03-01  

Identity

HGNC
JMJD6
LOCATION
17q25.1
LOCUSID
23210
ALIAS
PSR,PTDSR,PTDSR1
FUSION GENES
Show Gene Fusions

Other Information

Locus ID:

NCBI: 23210
MIM: 604914
HGNC: 19355
Ensembl: ENSG00000070495

Variants:

dbSNP: 23210
ClinVar: 23210
TCGA: ENSG00000070495
COSMIC: JMJD6

RNA/Proteins

Gene IDTranscript IDUniprot
ENSG00000070495ENST00000303996B2WTI3
ENSG00000070495ENST00000397625Q6NYC1
ENSG00000070495ENST00000445478Q6NYC1
ENSG00000070495ENST00000542934B2WTI4
ENSG00000070495ENST00000585429K7EJU9
ENSG00000070495ENST00000617192B2WTI4

Expression (GTEx)

0
5
10
15
20
25
30
35
Adipose - Subcutaneous
Adipose - Visceral
Adrenal Gland
Artery - Aorta
Artery - Tibial
Bladder
Brain - Amygdala
Brain - Anterior cingulate cortex
Brain - Caudate
Brain - Cerebellar Hemisphere
Brain - Cerebellum
Brain - Cortex
Brain - Frontal Cortex
Brain - Hippocampus
Brain - Hypothalamus
Brain - Nucleus accumbens
Brain - Putamen
Brain - Spinal cord
Brain - Substantia nigra
Breast - Mammary Tissue
Cells - Cultured fibroblasts
Cells - EBV - transformed lymphocytes
Cervix - Ectocervix
Cervix - Endocervix
Colon - Sigmoid
Colon - Transverse
Esophagus - Gastroesophageal Junction
Esophagus - Mucosa
Esophagus - Muscularis
Fallopian Tube
Heart - Atrial Appendage
Heart - Left Ventricle
Kidney - Cortex
Kidney - Medulla
Liver
Lung
Minor Salivary Gland
Muscle - Skeletal
Nerve - Tibial
Ovary
Pancreas
Pituitary
Prostate
Skin - Not Sun Exposed
Skin - Sun Exposed
Small Intestine - Terminal Ileum
Spleen
Stomach
Testis
Thyroid
Uterus
Vagina
Whole Blood

Pathways

PathwaySourceExternal ID
Chromatin organizationREACTOMER-HSA-4839726
Chromatin modifying enzymesREACTOMER-HSA-3247509
HDMs demethylate histonesREACTOMER-HSA-3214842

Protein levels (Protein atlas)

Not detected
Low
Medium
High
cerebral cortex
cerebellum
hippocampus
caudate
thyroid gland
parathyroid gland
adrenal gland
nasopharynx
bronchus
lung
oral mucosa
salivary gland
esophagus
stomach 1
stomach 2
duodenum
small intestine
colon
rectum
liver
gallbladder
pancreas
kidney
urinary bladder
testis
epididymis
seminal vesicle
prostate
vagina
ovary
fallopian tube
endometrium 1
endometrium 2
cervix, uterine
placenta
breast
heart muscle
smooth muscle
skeletal muscle
soft tissue 1
soft tissue 2
adipose tissue
skin 1
skin 2
appendix
spleen
lymph node
tonsil
bone marrow

References

Pubmed IDYearTitleCitations
179475792007JMJD6 is a histone arginine demethylase.210
195743902009Jmjd6 catalyses lysyl-hydroxylation of U2AF65, a protein associated with RNA splicing.139
243602792013Brd4 and JMJD6-associated anti-pause enhancers in regulation of transcriptional pause release.139
118774742002Elastase-mediated phosphatidylserine receptor cleavage impairs apoptotic cell clearance in cystic fibrosis and bronchiectasis.100
153450362004The phosphatidylserine receptor has essential functions during embryogenesis but not in apoptotic cell removal.66
213008892011Jumonji domain-containing protein 6 (Jmjd6) is required for angiogenic sprouting and regulates splicing of VEGF-receptor 1.54
227010202012Endothelial microparticle uptake in target cells is annexin I/phosphatidylserine receptor dependent and prevents apoptosis.47
206792432010Interaction of JMJD6 with single-stranded RNA.45
233031812013Lysyl 5-hydroxylation, a novel histone modification, by Jumonji domain containing 6 (JMJD6).45
246674982014JMJD6 promotes colon carcinogenesis through negative regulation of p53 by hydroxylation.39

Citation

Dessen P

JMJD6 (jumonji domain containing 6, arginine demethylase and lysine hydroxylase)

Atlas Genet Cytogenet Oncol Haematol. 2013-03-01

Online version: http://atlasgeneticsoncology.org/gene/53229/jmjd6