KAT8 (lysine acetyltransferase 8)

2011-08-01  

Identity

HGNC
LOCATION
16p11.2
LOCUSID
ALIAS
LIGOWS,MOF,MYST1,ZC2HC8,hMOF
FUSION GENES

Other Information

Locus ID:

NCBI: 84148
MIM: 609912
HGNC: 17933
Ensembl: ENSG00000103510

Variants:

dbSNP: 84148
ClinVar: 84148
TCGA: ENSG00000103510
COSMIC: KAT8

RNA/Proteins

Gene IDTranscript IDUniprot
ENSG00000103510ENST00000219797Q9H7Z6
ENSG00000103510ENST00000448516Q9H7Z6
ENSG00000103510ENST00000537402H3BMX5
ENSG00000103510ENST00000543774Q9H7Z6
ENSG00000103510ENST00000652764A0A494C0I2

Expression (GTEx)

0
50
100
150

Pathways

PathwaySourceExternal ID
Chromatin organizationREACTOMER-HSA-4839726
Chromatin modifying enzymesREACTOMER-HSA-3247509
HATs acetylate histonesREACTOMER-HSA-3214847

References

Pubmed IDYearTitleCitations
162275712005A human protein complex homologous to the Drosophila MSL complex is responsible for the majority of histone H4 acetylation at lysine 16.139
160248122005hMOF histone acetyltransferase is required for histone H4 lysine 16 acetylation in mammalian cells.124
204791232010MOF and histone H4 acetylation at lysine 16 are critical for DNA damage response and double-strand break repair.124
200188522010Subunit composition and substrate specificity of a MOF-containing histone acetyltransferase distinct from the male-specific lethal (MSL) complex.97
179678682008The mammalian ortholog of Drosophila MOF that acetylates histone H4 lysine 16 is essential for embryogenesis and oncogenesis.96
238639322013The histone H4 lysine 16 acetyltransferase hMOF regulates the outcome of autophagy.95
159236422005Involvement of human MOF in ATM function.91
199131212009Gene-centric association signals for lipids and apolipoproteins identified via the HumanCVD BeadChip.85
220201262012MYST protein acetyltransferase activity requires active site lysine autoacetylation.55
176940802007Males absent on the first (MOF): from flies to humans.54

Citation

Dessen P

KAT8 (lysine acetyltransferase 8)

Atlas Genet Cytogenet Oncol Haematol. 2011-08-01

Online version: http://atlasgeneticsoncology.org/gene/52336/kat8