Identity
HGNC
LOCATION
11p14.1
LOCUSID
ALIAS
HBK4,HK1,HPCN2,HUKII,KCNA4L,KCNA8,KV1.4,MCIDDS,PCN2
Non-annotated gene. Preliminary data : if you are an author who wish to write a full paper/card on this gene, contribute in submission tool
Other Information
Locus ID:
NCBI: 3739
MIM: 176266
HGNC: 6222
Ensembl: ENSG00000182255
Variants:
dbSNP: 3739
ClinVar: 3739
TCGA: ENSG00000182255
COSMIC: KCNA4
RNA/Proteins
| Gene ID | Transcript ID | Uniprot |
|---|---|---|
| ENSG00000182255 | ENST00000328224 | P22459 |
Expression (GTEx)
Pathways
| Pathway | Source | External ID |
|---|---|---|
| Neuronal System | REACTOME | R-HSA-112316 |
| Potassium Channels | REACTOME | R-HSA-1296071 |
| Voltage gated Potassium channels | REACTOME | R-HSA-1296072 |
Protein levels (Protein atlas)
References
| Pubmed ID | Year | Title | Citations |
|---|---|---|---|
| 36693615 | 2023 | miR-448 regulates potassium voltage-gated channel subfamily A member 4 (KCNA4) in ischemia and heart failure. | 3 |
| 36693615 | 2023 | miR-448 regulates potassium voltage-gated channel subfamily A member 4 (KCNA4) in ischemia and heart failure. | 3 |
| 35439054 | 2022 | An epilepsy-associated K(V)1.2 charge-transfer-center mutation impairs K(V)1.2 and K(V)1.4 trafficking. | 2 |
| 35439054 | 2022 | An epilepsy-associated K(V)1.2 charge-transfer-center mutation impairs K(V)1.2 and K(V)1.4 trafficking. | 2 |
| 34038243 | 2021 | Human adrenal glomerulosa cells express K2P and GIRK potassium channels that are inhibited by ANG II and ACTH. | 4 |
| 34038243 | 2021 | Human adrenal glomerulosa cells express K2P and GIRK potassium channels that are inhibited by ANG II and ACTH. | 4 |
| 30812034 | 2019 | KCNA4 Gene Variant is Auxiliary in Endurance Running Performance Level. | 0 |
| 30812034 | 2019 | KCNA4 Gene Variant is Auxiliary in Endurance Running Performance Level. | 0 |
| 22560931 | 2012 | K+ channel alterations in the progression of experimental autoimmune encephalomyelitis. | 23 |
| 22560931 | 2012 | K+ channel alterations in the progression of experimental autoimmune encephalomyelitis. | 23 |
| 21307345 | 2011 | Episodic ataxia type 1 mutations affect fast inactivation of K+ channels by a reduction in either subunit surface expression or affinity for inactivation domain. | 17 |
| 21945024 | 2011 | Hypermethylated DNA as potential biomarkers for gastric cancer diagnosis. | 17 |
| 21307345 | 2011 | Episodic ataxia type 1 mutations affect fast inactivation of K+ channels by a reduction in either subunit surface expression or affinity for inactivation domain. | 17 |
| 21945024 | 2011 | Hypermethylated DNA as potential biomarkers for gastric cancer diagnosis. | 17 |
| 19961828 | 2010 | N-glycans modulate K(v)1.5 gating but have no effect on K(v)1.4 gating. | 13 |
Citation
Dessen P
KCNA4 (potassium voltage-gated channel subfamily A member 4)
Atlas Genet Cytogenet Oncol Haematol. 2012-03-01
Online version: http://atlasgeneticsoncology.org/gene/52634/kcna4
