Identity
HGNC
LOCATION
21q22.12
LOCUSID
ALIAS
ISK,JLNS,JLNS2,LQT2/5,LQT5,MinK
FUSION GENES
Non-annotated gene. Preliminary data : if you are an author who wish to write a full paper/card on this gene, contribute in submission tool
Other Information
Locus ID:
NCBI: 3753
MIM: 176261
HGNC: 6240
Ensembl: ENSG00000180509
Variants:
dbSNP: 3753
ClinVar: 3753
TCGA: ENSG00000180509
COSMIC: KCNE1
RNA/Proteins
Expression (GTEx)
Pathways
PharmGKB
| Entity ID | Name | Type | Evidence | Association | PK | PD | PMIDs |
|---|---|---|---|---|---|---|---|
| PA151249535 | diuretics | Chemical | ClinicalAnnotation | associated | PD | ||
| PA164712406 | Antibiotics | Chemical | ClinicalAnnotation | associated | PD | ||
| PA447300 | Acquired Long QT Syndrome (aLQTS) | Disease | Literature, MultilinkAnnotation | associated | 24561134 | ||
| PA448383 | amiodarone | Chemical | ClinicalAnnotation | associated | PD | ||
| PA451209 | quinidine | Chemical | ClinicalAnnotation | associated | PD | ||
| PA451457 | sotalol | Chemical | ClinicalAnnotation | associated | PD | ||
| PA452233 | antipsychotics | Chemical | ClinicalAnnotation | associated | PD |
References
| Pubmed ID | Year | Title | Citations |
|---|---|---|---|
| 34958868 | 2022 | PKC-isoform specific regulation of receptor desensitization and KCNQ1/KCNE1 K(+) channel activity by mutant α(1B)-adrenergic receptors. | 0 |
| 34958868 | 2022 | PKC-isoform specific regulation of receptor desensitization and KCNQ1/KCNE1 K(+) channel activity by mutant α(1B)-adrenergic receptors. | 0 |
| 33373586 | 2021 | KCNE1 is an auxiliary subunit of two distinct ion channel superfamilies. | 13 |
| 33517668 | 2021 | Common Variants in KCNE1, KCNH2, and SCN5A May Impact Cardiac Arrhythmia Risk. | 2 |
| 33763865 | 2021 | Elevation of propofol sensitivity of cardiac I(Ks) channel by KCNE1 polymorphism D85N. | 0 |
| 34003017 | 2021 | Development of a Patient-Specific p.D85N-Potassium Voltage-Gated Channel Subfamily E Member 1-Induced Pluripotent Stem Cell-Derived Cardiomyocyte Model for Drug-Induced Long QT Syndrome. | 1 |
| 34195885 | 2021 | Genetic predictors of sick sinus syndrome. | 0 |
| 34282101 | 2021 | Association Analysis of Candidate Gene Polymorphisms and Tinnitus in Young Musicians. | 2 |
| 34285340 | 2021 | A general mechanism of KCNE1 modulation of KCNQ1 channels involving non-canonical VSD-PD coupling. | 4 |
| 33373586 | 2021 | KCNE1 is an auxiliary subunit of two distinct ion channel superfamilies. | 13 |
| 33517668 | 2021 | Common Variants in KCNE1, KCNH2, and SCN5A May Impact Cardiac Arrhythmia Risk. | 2 |
| 33763865 | 2021 | Elevation of propofol sensitivity of cardiac I(Ks) channel by KCNE1 polymorphism D85N. | 0 |
| 34003017 | 2021 | Development of a Patient-Specific p.D85N-Potassium Voltage-Gated Channel Subfamily E Member 1-Induced Pluripotent Stem Cell-Derived Cardiomyocyte Model for Drug-Induced Long QT Syndrome. | 1 |
| 34195885 | 2021 | Genetic predictors of sick sinus syndrome. | 0 |
| 34282101 | 2021 | Association Analysis of Candidate Gene Polymorphisms and Tinnitus in Young Musicians. | 2 |
Citation
Dessen P
KCNE1 (potassium voltage-gated channel subfamily E regulatory subunit 1)
Atlas Genet Cytogenet Oncol Haematol. 2007-02-01
Online version: http://atlasgeneticsoncology.org/gene/46537/kcne1
