KCNIP3 (potassium voltage-gated channel interacting protein 3)

2007-02-01  

Identity

HGNC
LOCATION
2q11.1
LOCUSID
ALIAS
CSEN,DREAM,KCHIP3
FUSION GENES

Other Information

Locus ID:

NCBI: 30818
MIM: 604662
HGNC: 15523
Ensembl: ENSG00000115041

Variants:

dbSNP: 30818
ClinVar: 30818
TCGA: ENSG00000115041
COSMIC: KCNIP3

RNA/Proteins

Gene IDTranscript IDUniprot
ENSG00000115041ENST00000295225Q9Y2W7
ENSG00000115041ENST00000295225A0A024RE22
ENSG00000115041ENST00000360990A0A0A0MRH3
ENSG00000115041ENST00000468529Q9Y2W7

Expression (GTEx)

0
5
10
15
20
25
30
35
40

Pathways

PathwaySourceExternal ID
Muscle contractionREACTOMER-HSA-397014
Cardiac conductionREACTOMER-HSA-5576891
Phase 1 - inactivation of fast Na+ channelsREACTOMER-HSA-5576894

Protein levels (Protein atlas)

Not detected
Low
Medium
High

References

Pubmed IDYearTitleCitations
272809752016Integration of TP53, DREAM, MMB-FOXM1 and RB-E2F target gene analyses identifies cell cycle gene regulatory networks.70
263845662016The p53-p21-DREAM-CDE/CHR pathway regulates G2/M cell cycle genes.67
197306832009The variant rs1867277 in FOXE1 gene confers thyroid cancer susceptibility through the recruitment of USF1/USF2 transcription factors.59
231878022012p53 can repress transcription of cell cycle genes through a p21(WAF1/CIP1)-dependent switch from MMB to DREAM protein complex binding at CHR promoter elements.47
287994332017Cell cycle transcription control: DREAM/MuvB and RB-E2F complexes.38
161778262005Transcriptional repressor DREAM regulates T-lymphocyte proliferation and cytokine gene expression.35
163063952005Downstream regulatory element antagonist modulator regulates Ca2+ homeostasis and viability in cerebellar neurons.34
171021342007G protein-coupled receptor kinase 2-mediated phosphorylation of downstream regulatory element antagonist modulator regulates membrane trafficking of Kv4.2 potassium channel.27
218137052011Disruption of repressive p130-DREAM complexes by human papillomavirus 16 E6/E7 oncoproteins is required for cell-cycle progression in cervical cancer cells.24
189574402008Multiple Kv channel-interacting proteins contain an N-terminal transmembrane domain that regulates Kv4 channel trafficking and gating.21

Citation

Dessen P

KCNIP3 (potassium voltage-gated channel interacting protein 3)

Atlas Genet Cytogenet Oncol Haematol. 2007-02-01

Online version: http://atlasgeneticsoncology.org/gene/45968/kcnip3