KCNJ12 (potassium inwardly rectifying channel subfamily J member 12)

2003-05-01  

Identity

HGNC
LOCATION
17p11.2
LOCUSID
ALIAS
IRK-2,IRK2,KCNJN1,Kir2.2,Kir2.2v,hIRK,hIRK1,hkir2.2x,kcnj12x
FUSION GENES

Other Information

Locus ID:

NCBI: 3768
MIM: 602323
HGNC: 6258
Ensembl: ENSG00000184185

Variants:

dbSNP: 3768
ClinVar: 3768
TCGA: ENSG00000184185
COSMIC: KCNJ12

RNA/Proteins

Gene IDTranscript IDUniprot
ENSG00000184185ENST00000331718Q14500
ENSG00000184185ENST00000583088Q14500

Expression (GTEx)

0
10
20
30
40
50
60
70
80
90

Pathways

PathwaySourceExternal ID
Cholinergic synapseKEGGhsa04725
Oxytocin signaling pathwayKEGGhsa04921
Oxytocin signaling pathwayKEGGko04921
Neuronal SystemREACTOMER-HSA-112316
Transmission across Chemical SynapsesREACTOMER-HSA-112315
Neurotransmitter Receptor Binding And Downstream Transmission In The Postsynaptic CellREACTOMER-HSA-112314
GABA receptor activationREACTOMER-HSA-977443
GABA B receptor activationREACTOMER-HSA-977444
Activation of GABAB receptorsREACTOMER-HSA-991365
Inhibition of voltage gated Ca2+ channels via Gbeta/gamma subunitsREACTOMER-HSA-997272
Potassium ChannelsREACTOMER-HSA-1296071
Inwardly rectifying K+ channelsREACTOMER-HSA-1296065
G protein gated Potassium channelsREACTOMER-HSA-1296059
Activation of G protein gated Potassium channelsREACTOMER-HSA-1296041
Classical Kir channelsREACTOMER-HSA-1296053
Muscle contractionREACTOMER-HSA-397014
Cardiac conductionREACTOMER-HSA-5576891
Phase 4 - resting membrane potentialREACTOMER-HSA-5576886

Protein levels (Protein atlas)

Not detected
Low
Medium
High

References

Pubmed IDYearTitleCitations
120323592002Heteromerization of Kir2.x potassium channels contributes to the phenotype of Andersen's syndrome.47
209212302010Direct and specific activation of human inward rectifier K+ channels by membrane phosphatidylinositol 4,5-bisphosphate.32
212815762011Dual-mode phospholipid regulation of human inward rectifying potassium channels.31
159585272005Functional expression of Kir2.x in human aortic endothelial cells: the dominant role of Kir2.2.28
267861622016Nav1.5 N-terminal domain binding to α1-syntrophin increases membrane density of human Kir2.1, Kir2.2 and Nav1.5 channels.19
163733862006Differential polyamine sensitivity in inwardly rectifying Kir2 potassium channels.12
125982322003Plasticity of KIR channels in human smooth muscle cells from internal thoracic artery.11
208413752010Knockdown of inwardly rectifying potassium channel Kir2.2 suppresses tumorigenesis by inducing reactive oxygen species-mediated cellular senescence.9
162587662006Regulation of cardiac inwardly rectifying potassium current IK1 and Kir2.x channels by endothelin-1.8
206766722010Functional consequences of Kir2.1/Kir2.2 subunit heteromerization.6

Citation

Dessen P

KCNJ12 (potassium inwardly rectifying channel subfamily J member 12)

Atlas Genet Cytogenet Oncol Haematol. 2003-05-01

Online version: http://atlasgeneticsoncology.org/gene/41049/kcnj12