KCNJ4 (potassium inwardly rectifying channel subfamily J member 4)

2009-11-01  

Identity

HGNC
LOCATION
22q13.1
LOCUSID
ALIAS
HIR,HIRK2,HRK1,IRK-3,IRK3,Kir2.3
FUSION GENES

Other Information

Locus ID:

NCBI: 3761
MIM: 600504
HGNC: 6265
Ensembl: ENSG00000168135

Variants:

dbSNP: 3761
ClinVar: 3761
TCGA: ENSG00000168135
COSMIC: KCNJ4

RNA/Proteins

Gene IDTranscript IDUniprot
ENSG00000168135ENST00000303592P48050
ENSG00000168135ENST00000303592A0A024R1L8

Expression (GTEx)

0
50
100
150

Pathways

PathwaySourceExternal ID
Cholinergic synapseKEGGhsa04725
Oxytocin signaling pathwayKEGGhsa04921
Oxytocin signaling pathwayKEGGko04921
Neuronal SystemREACTOMER-HSA-112316
Transmission across Chemical SynapsesREACTOMER-HSA-112315
Neurotransmitter Receptor Binding And Downstream Transmission In The Postsynaptic CellREACTOMER-HSA-112314
GABA receptor activationREACTOMER-HSA-977443
GABA B receptor activationREACTOMER-HSA-977444
Activation of GABAB receptorsREACTOMER-HSA-991365
Inhibition of voltage gated Ca2+ channels via Gbeta/gamma subunitsREACTOMER-HSA-997272
Potassium ChannelsREACTOMER-HSA-1296071
Inwardly rectifying K+ channelsREACTOMER-HSA-1296065
G protein gated Potassium channelsREACTOMER-HSA-1296059
Activation of G protein gated Potassium channelsREACTOMER-HSA-1296041
Classical Kir channelsREACTOMER-HSA-1296053
Muscle contractionREACTOMER-HSA-397014
Cardiac conductionREACTOMER-HSA-5576891
Phase 4 - resting membrane potentialREACTOMER-HSA-5576886

References

Pubmed IDYearTitleCitations
223964142012Striatal D2 receptors regulate dendritic morphology of medium spiny neurons via Kir2 channels.49
159585272005Functional expression of Kir2.x in human aortic endothelial cells: the dominant role of Kir2.2.28
181802912008AP-2-dependent internalization of potassium channel Kir2.3 is driven by a novel di-hydrophobic signal.17
196354852009Molecular mechanism of inward rectifier potassium channel 2.3 regulation by tax-interacting protein-1.13
163733862006Differential polyamine sensitivity in inwardly rectifying Kir2 potassium channels.12
162587662006Regulation of cardiac inwardly rectifying potassium current IK1 and Kir2.x channels by endothelin-1.8
184537432008Novel insights into the structural basis of pH-sensitivity in inward rectifier K+ channels Kir2.3.4
185037682008Kir2.3 knock-down decreases IK1 current in neonatal rat cardiomyocytes.3
305122372019Overexpression of KCNJ4 correlates with cancer progression and unfavorable prognosis in lung adenocarcinoma.1
204244732010L-type voltage-dependent calcium channel alpha subunit 1C is a novel candidate gene associated with secondary hyperparathyroidism: an application of haplotype-based analysis for multiple linked single nucleotide polymorphisms.0

Citation

Dessen P

KCNJ4 (potassium inwardly rectifying channel subfamily J member 4)

Atlas Genet Cytogenet Oncol Haematol. 2009-11-01

Online version: http://atlasgeneticsoncology.org/gene/51194/kcnj4